Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variantB.1.351 SARS-CoV-2 변이체의 감염 및 백신 유도 항체 결합 및 중화Article Published on 2021-04-142022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] additional spike mutation additional Spike mutations Antibody binding Antibody titer Antibody titers B.1 B.1.351 B.1.351 variant binding antibody convalescent COVID-19 patient D614G deletions domain Efficacy emerging variants exhibited humoral Humoral immunity individual individuals Infection Live virus Moderna Mutation neutralization neutralize Neutralizing antibody titer neutralizing antibody titers polyclonal antibodies polyclonal antibody protective humoral immunity raising Receptor-binding domain reduced reduction in retained SARS-CoV-2 SARS-CoV-2 B.1.351 variant SARS-CoV-2 variant SARS-CoV-2 variants sera spike mutation Spike protein the spike protein vaccinated individual Vaccine vaccine-induced antibodies variant Viral viral neutralization [DOI] 10.1016/j.chom.2021.03.009 PMC 바로가기 [Article Type] Article
Presence and short-term persistence of SARS-CoV-2 neutralizing antibodies in COVID-19 convalescent plasma donorsCOVID-19 회복기 혈장 기증자에서 SARS-CoV-2 중화 항체의 존재 및 단기 지속성Article Published on 2021-04-012022-09-11 Journal: Transfusion [Category] MERS, SARS, 진단, 치료기술, [키워드] Analysis antibody antibody levels Antibody Response Antibody titers Antigen approved best Blood blood component preparations. CCP Children's Hospital collected convalescent plasma correlation COVID-19 COVID-19 patients criteria detectable Donor donors drug evaluate evaluated FDA FFP transfusion focus food FRNT implementation individual less Live virus majority miss a neutralization neutralization test Neutralizing activity Neutralizing antibody titer neutralizing antibody titers Patient persistence Presence protocol quantitative assay Quantitative assays reduction Regulatory Regulatory and QA robust SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 neutralizing antibody SARS-CoV-2 nucleoprotein sustained therapeutic therapeutic use titer Treatment treatment of COVID-19 Variability [DOI] 10.1111/trf.16261 PMC 바로가기 [Article Type] Article
How should we use convalescent plasma therapies for the management of COVID-19?COVID-19 관리를 위해 회복기 혈장 요법을 어떻게 사용해야 합니까?Review Published on 2021-03-252022-09-11 Journal: Blood [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antibody Antibody titers antibody titers) benefit blood donor Blood donors Characteristics Clinical efficacy convalescent plasma Convalescent plasma therapy coronavirus COVID-19 effort high-quality randomized trial hyperimmune Immunoglobulin International management neutralizing antibody titers passive immunity patients with COVID-19 plasma reported respiratory severe acute respiratory syndrome Coronavirus transfusion Volume [DOI] 10.1182/blood.2020008903 PMC 바로가기 [Article Type] Review
Predictive Analysis of the Neutralization Activity in Convalescent Plasmas From COVID-19 Recovered Patients in Zhejiang Province, China, January-March, 20202020년 1월-3월 중국 저장성 코로나19 회복 환자의 회복기 혈장 중화 활성 예측 분석Cellular and Infection Microbiology Published on 2021-03-162022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 진단, 치료제, [키워드] activity anti-SARS-CoV-2 Antibody titers China Clinical use convalescent plasma correlated COVID-19 detect Donor drug ELISA ELISA-RBD exhibited IgG antibody IgG titer indirect ELISA infections Infusion Therapy Inpatient N protein NAb titer NAb titers neutralization activity Neutralization assay neutralizing antibody neutralizing antibody titers Patient plasma plasma sample plasma samples pseudovirus R 2 RBD RBD IgG titers recovered Result SARS-CoV-2 sensitivity significantly specificity substitute therapeutic option therapy Zhejiang [DOI] 10.3389/fcimb.2021.650487 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Use of convalescent serum reduces severity of COVID-19 in nonhuman primates회복기 혈청의 사용은 비인간 영장류에서 COVID-19의 심각성을 감소시킵니다Article Published on 2021-03-092022-09-12 Journal: Cell Reports [Category] MERS, SARS, 비임상, 진단, [키워드] acute respiratory syndrome African green monkey anti-SARS-CoV-2 antibodies antibody Clinical efficacy Coagulopathy controls convalescent convalescent plasma Convalescent plasma therapy convalescent sera convalescent serum coronavirus coronavirus disease COVID-19 difference Diseases Donor early stage effective group Human in viral Inflammatory Lung pathology neutralizing antibody titers Neutralizing titer nonhuman primate Passive pathology Patient provided receive reduce reduced reductions in SARS-CoV-2 sera serum severity severity of COVID-19 the disease therapeutic transfer treat Trial Viral pneumonia [DOI] 10.1016/j.celrep.2021.108837 PMC 바로가기 [Article Type] Article
Towards Quantitative and Standardized Serological and Neutralization Assays for COVID-19COVID-19에 대한 정량적이고 표준화된 혈청학적 및 중화 분석을 향하여Article Published on 2021-03-082022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] anti-RBD anti-SARS-CoV-2 Antibody titer Antigen approach Benchmarking complementary correlation COVID-19 Critical Cross reactivity cross-reactivity demonstrated diagnostic full-length help HKU1 IgG IgG and IgM IgM IMPROVE MERS monoclonal antibody reference standard Neutralization assay neutralization assays neutralizing antibody titers OC43 quantified Quantitative quantitative assay Quantitative assays quantitative serology assays RBD Receptor binding domain reference standard robust SARS-CoV SARS-CoV-2 virus SARS1 Sensitivity and specificity serological serology serology assay serology assays spike Spike proteins Surveillance the spike protein Vaccine development viruses [DOI] 10.3390/ijms22052723 PMC 바로가기 [Article Type] Article
Antibody Response to the BNT162b2 mRNA COVID-19 Vaccine in Subjects with Prior SARS-CoV-2 InfectionSARS-CoV-2 감염 이전에 BNT162b2 mRNA COVID-19 백신에 대한 항체 반응Clinical Trial Published on 2021-03-052022-08-13 Journal: Viruses [Category] SARS, 임상, 진단, [키워드] all subject all subjects analyzed Anti-spike anti-spike RBD IgG antibody antibody antibody levels Antibody Response Antibody titers BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine booster both groups control subject COVID-19 COVID-19 vaccine COVID-19 vaccines decrease develop domain effective response expected first dose Frequency healthcare worker IgG antibodies IgG antibody immune memory immune memory persist immune response immunogenicity individual induce infected individuals Infection local pain naïve individuals naïve subject naïve subjects natural infection Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers nine no significant difference not significantly different pre-existing immunity rapid increase RBD reactogenicity response SARS-CoV-2 SARS-COV-2 infection Side effects single dose subjects sustained the antibody response the vaccine titers vaccination Vaccine vaccine dose vaccine doses vaccine-associated side effects [DOI] 10.3390/v13030422 PMC 바로가기 [Article Type] Clinical Trial
Immunogenicity and Safety of an Inactivated SARS-CoV-2 Vaccine: Preclinical Studies비활성화된 SARS-CoV-2 백신의 면역원성과 안전성: 전임상 연구Article Published on 2021-03-032022-09-10 Journal: Vaccines [Category] 비임상, [키워드] Antibody titers approved AstraZeneca booster booster dose breath candidate vaccine challenge clinical development clinical trial control group country effective Efficacy Emergency use experimental models guinea pigs hamster hamsters immunogenicity immunological profile inactivated increase in Infection Laboratory mice Moderna morbidity mRNA Neutralizing antibody titer neutralizing antibody titers pandemic performed Phase I PIGS post vaccination pre-clinical study Preclinical preclinical studies RATs Safety safety evaluation SARS-CoV-2 SARS-CoV-2 vaccine shedding Sinopharm subjects tested the vaccine tolerable Vaccine vaccine safety virus [DOI] 10.3390/vaccines9030214 PMC 바로가기 [Article Type] Article
Titers of Neutralizing Antibodies against SARS-CoV-2 Are Independent of Symptoms of Non-Severe COVID-19 in Young AdultsSARS-CoV-2에 대한 중화 항체 역가는 젊은 성인에서 심각하지 않은 COVID-19의 증상과 무관합니다Brief Report Published on 2021-02-122022-09-01 Journal: Viruses [Category] MERS, 진단, [키워드] Adults antibody Antibody titers asymptomatic infection Cluster convalescent COVID-19 disease ELISA homogeneous humoral humoral immune response Humoral immunity independent of induce infected individuals male Neutralizing antibodies Neutralizing antibody response neutralizing antibody titers not differ onset of symptoms outbreak Patient produced remained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Serum Neutralization severe disease SNT symptoms of COVID-19 titer titers virus neutralization test young adults [DOI] 10.3390/v13020284 PMC 바로가기 [Article Type] Brief Report
Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers감염된 의료 종사자 중 SARS-CoV-2에 대한 중화 항체의 급격한 감소Article Published on 2021-02-082022-09-12 Journal: Nature Communications [Category] MERS, 진단, [키워드] anti-RBD antibody Antibody titers association binding domain boost concerning correlated COVID-19 declines decrease disease onset elicit Evidence HCW healthcare worker humoral humoral immune response IgA IgG IgM immune protection individual Infection prevention maintain measure Mild MONITOR nAb response NAb titer NAb titers NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers onset of symptoms persistence potential risk Prevention and control Rapid RBD recommendation Reinfection required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination significant decrease Support viral infection [DOI] 10.1038/s41467-021-21111-9 PMC 바로가기 [Article Type] Article