Emimycin and its nucleoside derivatives: Synthesis and antiviral activityArticle Published on 2018-01-202023-06-01 Journal: European journal of medicinal chemistry [Category] 두창, 수두, 홍역, [키워드] Antiviral Emimycin nucleoside Pyrazine. [DOI] 10.1016/j.ejmech.2017.12.018
Lopinavir plus nucleoside reverse-transcriptase inhibitors, lopinavir plus raltegravir, or lopinavir monotherapy for second-line treatment of HIV (EARNEST): 144-week follow-up results from a randomised controlled trialHIV의 2차 치료를 위한 로피나비르 + 뉴클레오시드 역전사효소 억제제, 로피나비르 + 랄테그라비르 또는 로피나비르 단독요법(EARNEST): 무작위 대조 시험의 144주 추적 결과Article Published on 2018-01-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] adverse event African AID analysed Analysis Antiretroviral therapy ART assigned best clinical Combination combination therapy completion computer-generated cooperation country criteria Developing development Efficacy eligibility European event finding FIVE Follow-up funding GRADE grade 3 group HIV-infected people inferiority inhibitor inhibitors intervention group ISRCTN Kenya less limit Lopinavir Medical Research Council Modification monotherapy no difference non-inferiority non-inferiority margin nucleoside offer offered outcome participant partnership Patient per day primary analysis Primary outcome protease Protease inhibitor raltegravir randomisation randomised controlled trial Randomly receive recent regimen regimens Registered Ritonavir screened sequence Serious Adverse Events Swedish Treatment treatment of HIV Trial two-sided α Uganda Viral Viral load viral loads Virological WHO WHO criteria WHO guideline Zimbabwe [DOI] 10.1016/S1473-3099(17)30630-8 PMC 바로가기 [Article Type] Article
Lamivudine versus entecavir in the rescue of chemotherapy-induced hepatitis B flare-upComparative Study Published on 2017-12-012023-06-15 Journal: Journal of the Chinese Medical Association [Category] B형 간염, [키워드] Chemotherapy hepatic failure Immunosuppression nucleoside nucleotide [DOI] 10.1016/j.jcma.2017.07.009 [Article Type] Comparative Study
Lamivudine versus entecavir in the rescue of chemotherapy-induced hepatitis B flare-upComparative Study Published on 2017-12-012023-06-15 Journal: Journal of the Chinese Medical Association [Category] B형 간염, [키워드] Chemotherapy hepatic failure Immunosuppression nucleoside nucleotide [DOI] 10.1016/j.jcma.2017.07.009 [Article Type] Comparative Study
A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis2단계 수송 경로를 통해 모세포가 Bacillus subtilis에서 발달 중인 포자를 양육할 수 있습니다.Research Article Published on 2017-09-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accumulation Bacillus anthracis Bacillus subtilis Bacteria Bacterial Cell Clostridium difficile complex Concentration conserved Culture culture medium dehydration desiccation dipicolinic acid displace dormancy dormant dry weight engulfment enzyme Enzymes Evidence Express Factor forespore hallmark hallmarks homolog homologs idea late stage mechanism medium membrane membranes molecular basis Morphological mother mother cell Mutagenesis non-pathogenic bacteria nucleoside pathogenic pathway predicted produced Protective Protein pyridine-2,6-dicarboxylic acid remained required residue residues small molecule spore spore core spores sporulation Support translocated Transport vegetative growth water [DOI] 10.1371/journal.pgen.1007015 PMC 바로가기 [Article Type] Research Article
Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial공중 보건 접근법에서 뉴클레오시드 역전사효소 억제제 교차 내성 및 2차 항레트로바이러스 요법의 결과: 무작위, 공개, EARNEST 시험 내 관찰 분석Articles Published on 2017-05-082022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] AID Analysis Antiretroviral therapy ART assigned association baseline calculated clinical cooperation Cross-resistance Developing development European Evidence expected finding Follow-up funding Genotype genotypic greater impair inhibitor ISRCTN Lopinavir Medical Research Council monotherapy nucleoside Open-label outcome over partnership Patient patients with HIV predict predicted protease Protease inhibitor public health raltegravir randomised Randomised trial Randomly Registered Ritonavir sub-Saharan Africa Support Swedish tested therapy Treatment outcome Trial Viral Viral load Virological virological outcome virological outcomes WHO WHO criteria with HIV [DOI] 10.1016/S2352-3018(17)30065-6 PMC 바로가기 [Article Type] Articles
Influence of Treg cells and HBV genotype on sustained response and drug resistance in the treatment with nucleoside drugsArticle Published on 2017-03-022023-05-25 Journal: Brazilian Journal of Medical and Biological Resear [Category] B형 간염, Fulltext, [키워드] CD4+CD25+ CD8+CD28- Hepatitis B chronic nucleoside regulatory T cells viral response [DOI] 10.1590/1414-431X20165796 PMC 바로가기
The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug DesignReview Published on 2016-11-012023-06-14 Journal: Medicinal research reviews [Category] Fulltext, 신종인플루엔자, [키워드] Antiviral cap-snatching Influenza virus nucleoside polymerase [DOI] 10.1002/med.21401 PMC 바로가기 [Article Type] Review
Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents, and young adults (BREATHER): a randomised, open-label, non-inferiority, phase 2/3 trialHIV에 감염된 어린이, 청소년 및 젊은 성인(BREATHER)에 대한 주말 휴무 에파비렌즈 기반 항레트로바이러스 요법: 무작위, 공개, 비열등성, 2/3상 시험Articles Published on 2016-06-202022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 abortion adherent adverse event African age Antiretroviral therapy ART assigned block BREATHER CD4 cell Cell children clinician computer-generated country CTA Dizziness drug efavirenz eligible participant Eligible participants EudraCT European European Commission event finding FIVE France funding grade 3 gynaecomastia headache HIV-1 ideation inferiority inhibitors Intention intention to treat IQR ISRCTN Kaplan-Meier method less life Lipodystrophy list median median age Medical Research Council men neutropenia non-inferiority non-inferiority margin non-inferiority trial nucleoside occurred offer Open-label participant Patient phase 2/3 trial Primary outcome proportion raised randomisation randomisation list randomised Randomly reached Registered reverse transcriptase RNA safety profile Seven shown spontaneous abortion stratified Suicidal ideation Syncope technology Technology assessment the Kaplan-Meier method therapy Toxicity transaminases transcriptase Trial Viral Viral load virological suppression was done web service [DOI] 10.1016/S2352-3018(16)30054-6 PMC 바로가기 [Article Type] Articles
Abacavir, zidovudine, or stavudine as paediatric tablets for African HIV-infected children (CHAPAS-3): an open-label, parallel-group, randomised controlled trial아바카비르, 지도부딘 또는 스타부딘을 아프리카 HIV 감염 소아용 정제로 사용(CHAPAS-3): 공개 라벨, 병렬 그룹, 무작위 대조 시험Articles Published on 2016-02-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] abacavir adverse event adverse events African analysed Antiretroviral therapy ART children clinical database Developing drugs dual efavirenz enrolled European finding Follow-up funding groups hazard ratio hypersensitivity hypersensitivity reactions immunological inhibitor Intention intention to treat ISRCTN registry Laboratory lamivudine less Lipodystrophy median median age nevirapine nucleoside occurred Open-label parallel-group partnership primary endpoint randomisation randomised controlled trial Randomised trial Registered responses stavudine suppression Tablet Toxicity Treatment Trial Uganda Viral Viral load Virological were excluded WHO zidovudine [DOI] 10.1016/S1473-3099(15)00319-9 PMC 바로가기 [Article Type] Articles