Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patientsCOVID-19 환자에서 유도성 응고병증의 후보 기전으로서 셀레노시스테인 합성 장애Article Published on 2021-02-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 유전자 메커니즘, [키워드] Coagulopathy complication of COVID-19 COVID 19 patient COVID 19 patients COVID-19 patient Critical Critical illness endothelial Endothelium epidemiological Evidence homeostasis immune response impairment latency mechanism Perturbation perturbations physiological functions platelet activation Platelets SARS-CoV-2 Selenium selenocysteine Taking transcriptomic [DOI] 10.1016/j.mehy.2020.110475 PMC 바로가기 [Article Type] Article
Thrombosis and Coagulopathy in COVID-19: Current Understanding and Implications for Antithrombotic Treatment in Patients Treated With Percutaneous Coronary InterventionCardiovascular Medicine Published on 2021-01-182022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Activation antiplatelet antithrombotic therapy antithrombotic treatment autopsy study bleeding changes changes in characterized clinical Coagulopathy complex Complication Coronary Coronary heart disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-related death current disease Effectiveness Endothelial dysfunction event global pandemic Hospitalization implicated information management mechanism multiple organ failure occur Pathogenesis Patient Percutaneous Percutaneous coronary intervention Platelet platelet activation syndrome the disease therapy thrombosis undergo understanding [DOI] 10.3389/fcvm.2020.599334 PMC 바로가기 [Article Type] Cardiovascular Medicine
SARS-CoV-2 infection is associated with a pro-thrombotic platelet phenotypeSARS-CoV-2 감염은 전혈전성 혈소판 표현형과 관련이 있습니다Article Published on 2021-01-052022-09-11 Journal: Cell Death & Disease [Category] 치료기술, [키워드] abnormal coagulation Activation addition Adhesion Molecule adhesion molecules antibodies antiplatelet Antithrombotic cardiovascular complications CD63 characterized Coagulation complex condition contribute Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19 sample COVID-19 samples Cytometry donors expressed expression healthy control healthy controls hospitalized COVID-19 patient hospitalized COVID-19 patients hypercoagulable Hypercoagulable state in vitro incidence intensity intensive care intensive care support interactions investigated involved LAMP marker mass Mechanisms of disease median novel Novel coronavirus novel coronavirus disease P-selectin parameter patients peptide phenotype phenotypical Platelet platelet activation Platelets pro-thrombotic reduced Research SARS-COV-2 infection selectin signal intensity significantly Stimulation Support thrombin thrombin receptor transmembrane protein TRAP Treatment viral infection [DOI] 10.1038/s41419-020-03333-9 PMC 바로가기 [Article Type] Article
Platelet hyperactivity in COVID-19: Can the tomato extract Fruitflow® be used as an antiplatelet regime?Article Published on 2021-01-042023-06-15 Journal: Medical Hypotheses [Category] MERS, [키워드] blood pressure Coagulation COVID-19 Fruitflow® Human platelets immunothrombosis Inflammation platelet activation Platelet hyperactivity SARS-CoV-2 virus Water-soluble tomato extract [DOI] 10.1016/j.mehy.2020.110480 PMC 바로가기 [Article Type] Article
Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical ReviewReview Published on 2021-01-032022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activated Activation acute distress respiratory syndrome acute respiratory distress addition ARDS bleeding cause clinical evidence clinical manifestation clinical presentation clinician Coagulation coagulation cascade coagulation disorder coagulation factor coagulation tests Coagulopathy coronavirus disease COVID-19 COVID-19 patients Critically ill patient Disseminated intravascular coagulation endothelial endotoxin hemorrhagic event heparin Ill impairment incidence infiltration Inflammatory inhibitors Laboratory Laboratory test marker mechanism microthrombi Necrosis pathophysiology pathway Platelet platelet activation Platelets Protein protein S quantification question Regulatory reported respiratory responsible review risk supportive care syndrome thromboembolic Thromboembolic events thrombosis tissue variety [DOI] 10.3390/jcm10010140 PMC 바로가기 [Article Type] Review
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortalityJAK 억제는 SARS-CoV-2 간 감염성을 감소시키고 염증 반응을 조절하여 이환율 및 사망률을 감소시킵니다Observational Study Published on 2021-01-012022-09-11 Journal: Science Advances [Category] 신약개발, 임상, 진단, 치료제, [키워드] 95% CI ACE2 expression adverse events Antiviral antivirals Baricitinib benefit Cell cells Cohort controlled trials Culture cytokine Cytokine storm Efficacy elderly patients greater host protein host proteins human liver increase Inflammatory response inhibited inhibitor interferon Jak janus Janus kinase kinases liver liver cells median age Microscopy moderate-severe modulate morbidity and mortality Mortality outcome parenchymal parenchymal cells Patient platelet activation Pneumonia Randomized controlled trials reduce Replication reveal RNA-Seq SARS-CoV-2 SARS-CoV-2 pneumonia the cytokine storm Viral viral entry viral load quantification [DOI] 10.1126/sciadv.abe4724 PMC 바로가기 [Article Type] Observational Study
Coagulation abnormalities in SARS-CoV-2 infection: overexpression tissue factorReview Published on 2020-12-152022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] abnormality Activation addition alveolar cells angiotensin converting enzyme Angiotensin II Apoptosis bind Cell coagulation cascade Coagulation system Coagulopathy complex Complication COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Critical Cytokine storms death dysregulated enzyme expression Factor Hemostasis IL-1β IL-6 increased risk induce infect Inflammatory cytokine inhibitor involved life-threatening lymphocyte macrophages monocytes/macrophages Mortality multiorgan failure Myocardial infarction occur overexpression pathway patients platelet activation Platelets Proinflammatory cytokine proinflammatory cytokines receptor reduce risk S protein SARS-CoV-2 stroke surface the cytokine storm these cell Thromboembolism thrombosis tissue Tissue Factor TLR TNF-α transmembrane viral infection viral infections [DOI] 10.1186/s12959-020-00250-x PMC 바로가기 [Article Type] Review
Thrombocytopenia and thrombosis in hospitalized patients with COVID-19Editorial Published on 2020-12-012022-10-29 Journal: Journal of Hematology & Oncology [Category] COVID-19, MERS, SARS, [키워드] activated acute respiratory syndrome addition anticoagulation caused condition coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical D-dimer Factor high risk hospitalized patient immune increased mortality increasingly Infection Inflammation Multiple platelet activation responsible SARS-CoV-2 SARS-COV-2 infection scoring system therapy thrombocytopenia thromboembolic complication Thromboprophylaxis thrombosis Thrombus with COVID-19 [DOI] 10.1186/s13045-020-01003-z PMC 바로가기 [Article Type] Editorial
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic OpportunitiesPharmacology Published on 2020-11-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute lung injury ADA adenosine adenosine deaminase adenosine kinase ADK binding caused CD26 coronavirus COVID COVID-19 COVID-19 pathogenesis develop highlight IMPROVE Infection lung epithelia Lung injury novel coronavirus disease opportunity outbreak outcomes platelet activation receptor reduce respiratory role SARS-CoV-2 SARS-COV-2 infection Spread the disease therapeutic use thrombosis virus [DOI] 10.3389/fphar.2020.594487 PMC 바로가기 [Article Type] Pharmacology
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus MacaquesSARS-CoV-2에 감염된 붉은털 원숭이의 혈관 질환 및 혈전증Case Reports Published on 2020-11-252022-09-11 Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Analysis Bronchoalveolar lavage C-reactive protein clinical Clinical features Coagulation collagen complement COVID-19 COVID-19 pandemic Critical endothelial feature Human IFNα IL-1 IL-6 IL-8 include infected with SARS-CoV-2 Inflammation Inflammatory Interaction lead lung Lungs macaque macaques Macrophage molecular morbidity and mortality MX1 NF-κB pathway performed Peripheral blood Platelet platelet activation potential therapeutic target potential therapeutic targets proinflammatory proteomic rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 pathogenesis serum thrombosis TNFα transcriptomic Transcriptomic analyses upregulation Vascular vascular disease vascular thrombosis vWF [DOI] 10.1016/j.cell.2020.10.005 PMC 바로가기 [Article Type] Case Reports