Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk플랫폼 COVID-19에 대한 개입의 무작위 시험 In The old people (PRINCIPLE): 무작위, 통제, 공개, 적응 플랫폼에 대한 프로토콜, 고위험군에서 COVID-19 증후군에 대한 지역사회 치료 시험Article Published on 2021-06-182022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] adaptive addition Azithromycin clinical trial clinical trials collected Community Comorbidities complications conferences Contact Course COVID-19 COVID-19 infection death doxycycline Efficacy Eligible participants Ethical approval Ethics EudraCT evaluate futility General practice Health Service higher risk Hospital admission Hydroxychloroquine illness duration Inclusion Infectious diseases Interim analyses interim analysis Intervention intervention arm IRAS Master protocol modify Not completed Older Open-label outcome outcomes participant peer-reviewed platform Potential treatment potential treatments primary care Probability protocol randomisation randomisation probabilities randomised receive reduce registration number Research Research Ethics Result South study drug Symptom symptomatic Treatment treatments for COVID-19 Trial usual care website [DOI] 10.1136/bmjopen-2020-046799 PMC 바로가기 [Article Type] Article
Early Returns on Small Molecule Therapeutics for SARS-CoV-2SARS-CoV-2에 대한 저분자 치료제의 조기 수익Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 신약개발, 치료제, [키워드] approach breadth clinical testing Computational approaches COVID-19 pandemic determine effort Extraordinary identify molecule Pandemics Potential treatment potential treatments preparation progression return SARS-CoV-2 SARS-COV-2 infection Scientific community small molecule Therapeutics treat [DOI] 10.1021/acsinfecdis.0c00874 PMC 바로가기 [Article Type] Article
Pharmacogenomic considerations for repurposing of dexamethasone as a potential drug against SARS-CoV-2 infectionSARS-COV-2 감염에 대한 잠재적 약물로서 덱사메타손의 용도를 다른 용도를위한 약물 유전전증 고려 사항Review Published on 2021-06-042022-08-31 Journal: Personalized Medicine [Category] MERS, SARS, 신약개발, 유전자 메커니즘, [키워드] Abstract agonist analgesic effect analgesic effects anti-inflammatory drug benefit changes in chronic patients clinically Control Corticosteroid COVID-19 COVID-19 case Critical cure CYP3A5 Dexamethasone drug drug response Effect effort evaluate Factor Genetic genetic factors Genetic variation glucocorticoid Glucocorticoid receptors Health Organization immunomodulatory drugs individual individuals inherent involved metabolism metabolome NR3C1 NR3C2 outcome pathway Patient patients pharmacogenetics pharmacokinetic pharmacokinetics Potential treatment Randomized controlled trials receptors recovery RECOVERY trial reduce mortality Regulatory reported SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient severe COVID-19 patients therapy Transcriptome United Kingdom Usage World Health Organization [DOI] 10.2217/pme-2020-0183 PMC 바로가기 [Article Type] Review
Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trialResearch article Published on 2021-06-012022-10-05 Journal: The Lancet Rheumatology [Category] 임상, [키워드] 1:1 adverse event analysed assigned benefit C-reactive protein concentration colony stimulating factor Confidence intervals COVID-19 death deaths double-blind enrolled enrolment evaluate finding funding GM-CSF groups hospital hospitalisation hypoxaemia IMPROVE Inflammatory response initiated intention-to-treat population investigator investigator-initiated mechanical ventilation monoclonal antibody multicentre nine no significant difference Odds ratio outcome Oxygen therapy participant Patient patient population patients with COVID-19 Placebo placebo-controlled trial Pneumonia Potential treatment primary endpoint Primary outcome proportion randomised Randomised trial Randomly receive receptor Registered required Research Respiratory failure Seven Severe COVID-19 pneumonia single intravenous infusion Stratification Supplemental oxygen therapy systemic hyperinflammation the placebo group therapy Treatment Trial USA was done were excluded [DOI] 10.1016/S2665-9913(21)00070-9 [Article Type] Research article
Ivermectin as a potential treatment for COVID-19?Covid-19에 대한 잠재적 치료로서의 Ivermectin?Formal Comment Published on 2021-06-012022-09-10 Journal: PLoS Neglected Tropical Diseases [Category] SARS, 임상, [키워드] Potential treatment [DOI] 10.1371/journal.pntd.0009446 PMC 바로가기 [Article Type] Formal Comment
Toxicity of hydroxychloroquine, a potential treatment for COVID-19, on free-living marine nematodesResearch article Published on 2021-06-012022-10-05 Journal: Marine pollution bulletin [Category] SARS, 치료법, [키워드] anticipated Concentration concentrations COVID-19 COVID-19 crisis Diversity Ecotoxicity Free-living marine nematodes HCQ high risk highest Hydroxychloroquine index microcosm nematode patients Potential treatment response risk Seafood treatment for COVID-19 Trophic widespread [DOI] 10.1016/j.marpolbul.2021.112361 [Article Type] Research article
Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants’ spike protein–an in silico analysisResearch Article Published on 2021-05-262022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] 501Y.V1 501Y.V2 Analysis appear computational tools contribute death faster in silico Increased increased risk information intramolecular interaction Neutrophil elastase new SARS-CoV-2 Potential treatment Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Spike protein Spread stability Transmissibility variant virus Wuhan [DOI] 10.1371/journal.pone.0251426 PMC 바로가기 [Article Type] Research Article
Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study칼시페디올 치료 및 COVID-19로 인한 병원 사망률: 코호트 연구Clinical Trial Published on 2021-05-212022-08-13 Journal: Nutrients [Category] SARS, 임상, [키워드] 25-hydroxyvitamin D 95% CI acute respiratory distress acute respiratory distress syndrome administration Admission age Blood urea nitrogen C-reactive protein calcifediol calcifediol treatment Chronic kidney disease cohort study Comorbidity confounders Confusion Context COVID-19 COVID-19 drug treatment COVID-19 patients CURB CURB-65 score death Diastolic blood pressure FIVE hospital Hospital mortality Hospitalized Hospitalized care in-hospital mortality Interpretation Kidney disease laboratory-confirmed Laboratory-confirmed COVID-19 limit main outcome measure male median age moderate Mortality mortality rate mortality risk multicenter multivariable logistic regression multivariable logistic regression model nitrogen non-randomized open oral calcifediol Patient patients hospitalized patients receiving calcifediol Pneumonia Potential treatment Protein receiving respiratory distress respiratory rate Sample size SARS-CoV-2 severity significant difference significant differences significantly South Spain syndrome Systolic blood pressure Treatment treatment with calcifediol urea Vitamin D with COVID-19 [DOI] 10.3390/nu13061760 PMC 바로가기 [Article Type] Clinical Trial
Available medications used as potential therapeutics for COVID-19: What are the known safety profiles in pregnancyCOVID-19의 잠재적 치료제로 사용 가능한 약물: 임신 중 알려진 안전성 프로파일은 무엇입니까?Research Article Published on 2021-05-192022-09-10 Journal: PLoS ONE [Category] SARS, 신약개발, 치료제, [키워드] 95%CI Adjusting age angiotensin ARB Azithromycin Birth weight blocker caution Chloroquine clinical trial clinical trials condition confounder confounders congenital malformation COVID-19 Dexamethasone during pregnancy eligible excluded exposure to gestational age gestational period heparin heparins HIV Hydroxychloroquine increased risk indication indications interferon interferons LBW Low birth weight medication medications oseltamivir outcomes Potential treatment potential treatments pregnancies Pregnancy pregnant women Prematurity quantified Result risk safety profile Taking treat treatments for COVID-19 trials unique with COVID-19 women [DOI] 10.1371/journal.pone.0251746 PMC 바로가기 [Article Type] Research Article
Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus InfectionMicrobiology Published on 2021-05-142022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] absence acute respiratory syndrome Against arise autophagy autophagy machinery cascade Chloroquine complexes connection coronavirus coronavirus disease coronaviruses (CoVs) COVID-19 COVID-19 patient cytotoxic effects deaths disease pathogenesis facilitate host cell Hydroxychloroquine inhibitor knowledge membrane vesicle other coronaviruses pathway Potential Potential treatment question recent remained Replication RNA synthesis Safe SARS-CoV-2 SARS-COV-2 infection Spread the disease Treatment Vaccine viral pathogenesis viral replication virophagy worldwide pandemic Wuhan, China [DOI] 10.3389/fmicb.2021.675419 PMC 바로가기 [Article Type] Microbiology