Phase II/III trial of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy in severe COVID-19 patients: study protocol for a randomized controlled trialArticle Published on 2022-11-082022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] adaptive anti-COVID-19 IVIG antivirals clinical evidence clinical trial collected convalescent convalescent plasma COVID-19 cumulative death Efficacy eligibility criteria evaluate Health hyperimmune immunization immunomodulators intravenous Intravenous immunoglobulin low dose monoclonal antibodies Neutralizing non-specific novel Novel coronavirus outcome Passive passive immunization Patient phase Pneumonia polyclonal polyclonal antibodies Pooled convalescent plasma Potential treatment Randomized Randomized controlled trial receive Recovered COVID-19 patients reported SARS CoV-2 SARS-CoV-2 sealed Secondary outcomes severe COVID-19 severe COVID-19 patient severe COVID-19 patients Standard of care Steroids Study protocol therapeutic option therapy treat Treatment Trial variant variants of concern virus virus particles World Health Organization [DOI] 10.1186/s13063-022-06860-2 PMC 바로가기
The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6Article Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] antibodies antibody Antibody escape mutation binding binding interaction claimed COVID-19 human population IMPROVE molecular Mutation mutations N501Y Neutralizing antibodies neutralizing antibody pathogen Potential treatment predicted previous study Receptor binding domain responsible resulting S-RBD SARS-CoV-2 severity of COVID-19 the SARS-CoV-2 therapeutic [DOI] 10.1038/s41598-022-23482-5 PMC 바로가기
Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trialArticle Published on 2022-11-022022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] approved assessment baseline Blood Cardiology case sery chronic fatigue syndrome chronic inflammation clinical clinical trial cognitive collected common COVID-19 defined domain double-blind dysfunction Effect effective Efficacy endothelial function Ethics evaluate fatigue healthy subject hyperbaric oxygen hypothese immunology IMPROVE Inconclusive independent individual initial institutional review board Long malaise mechanism monitoring board oxygen Oxygen therapy pandemic Patient peer-reviewed performed physical placebo-controlled placebo-controlled clinical trial positive Potential treatment product protocol Quality of life Questionnaires randomised rehabilitation medicine respiratory medicine (see thoracic medicine) secondary endpoint suggested survey Swedish Symptom syndrome the primary endpoint Treatment Trial VASCULAR MEDICINE. [DOI] 10.1136/bmjopen-2022-061870 PMC 바로가기
Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies실험 및 도킹 연구를 통해 밝혀진 중국 Dagang Tea 성분의 코로나바이러스에 대한 다중 표적 메커니즘Article Published on 2022-10-282022-09-11 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis antibody antiviral activity Antiviral effect betulinic acid Chemical profile China Chinese Cold colds Compound coronavirus Coronaviruses CPE Cytopathic effect demonstrated docking docking analysis docking study Efficacy enzyme Enzyme inhibition eriodictyol Eurya evaluated exhibited experiment Fever fevers flavonoids Guangdong HCoV-OC43 herbal tea immunofluorescence in vitro infected cells Influenza inhibitory effect Inhibitory effects material mechanism Microscopic monomer naringenin OC43 optical performed PLPro Potential treatment potential treatments Prevent quercetin reduction SARS-CoV-2 tea Traditional Chinese medicine transmission electron microscopy treat Treatment viral infections Virtual screening virus particle virus particles [DOI] 10.1016/j.jep.2022.115528 PMC 바로가기 [Article Type] Article
Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels-A pilot study in healthy individuals with implications for COVID-19 and ARDSArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] 치료제, [키워드] ACE2 ACE2 expression acute respiratory distress alarmin Analysis angiotensin-converting enzyme 2 Antiviral ARDS ARDS patient baseline baseline levels blood sample cause cellular change collected coronavirus disease COVID-19 enrolled enzyme-linked immunosorbent exhibit expression glycyrrhizin healthy individual healthy volunteer HMGB1 hospitalised COVID-19 patient hospitalised patient immunomodulatory property implication in healthy individual in healthy individuals individual individuals liquorice material Mild modulate Non-COVID-19 not different Patient patients pilot study Plasma HMGB1 Potential treatment pro-inflammatory receptor ACE2 reduced reduction in Respiratory disease significantly significantly higher syndrome viral entry were measured with mild disease [DOI] 10.1371/journal.pone.0275181 PMC 바로가기
Comparable bidirectional neutrophil immune dysregulation between Kawasaki disease and severe COVID-19Article Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] 24 hour acute respiratory syndrome aged neutrophils analyses bidirectional children Clustering comparable Control controls coronavirus COVID-19 Critical demonstrated downloaded dysregulation enrolled expression Fever functional gene cluster Health Hierarchical hyperinflammatory state immune dysregulation Inflammatory Influenza Kawasaki disease mechanisms MHC class neutrophil neutrophil activation neutrophilic nuclei occur overactivation overlapping Patient performed Potential treatment reduction representing SARS-CoV-2 Sequence Read Archive severe COVID-19 Single-cell RNA sequencing syndrome target Treatment [DOI] 10.3389/fimmu.2022.995886 PMC 바로가기
Clinical Practice Guidelines From the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent PlasmaArticle Published on 2022-09-012022-11-15 Journal: Annals of internal medicine [Category] SARS, 진단, 치료기술, [키워드] AABB addition Admission advancement antibody assessment Biotherapy CCP clinical Clinical practice close contact convalescent plasma Coronavirus disease 2019 COVID-19 development Disease progression effective Evidence Good Clinical Practice GRADE framework guideline high risk Hospitalized hospitalized patient immunosuppressed patient Immunosuppression infected patient lack Meta-analysis moderate Neutralizing titer Outpatient Participants Potential treatment Practice Prophylactic Randomized controlled trial RCT RCTs recommendation recommendations SARS-CoV-2 SARS-CoV-2 antibody severe disease Standard of care symptom onset systematic review transfused uninfected with COVID-19 [DOI] 10.7326/M22-1079 PMC 바로가기
Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infectionArticle Published on 2022-09-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Activation Affect Antiviral Biomarker blood cell change changes in Cohort coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNA DNA methylation effector Epigenetic epigenetics expression expression of gene Hospitalized identify Infection intensive care unit Interaction interferon response involved lesion management Methylation MOST outcomes pathology pathophysiology pathway Patient populations Potential treatment recent reported SARS-CoV-2 SARS-COV-2 infection Severity of infection shown subset Symptom Symptoms the disease transcriptomics upper respiratory tract [DOI] 10.1016/j.biopha.2022.113396 PMC 바로가기
Sociodemographic Characteristics and Comorbidities of Patients With Long COVID and Persistent Olfactory DysfunctionArticle Published on 2022-09-012022-11-16 Journal: JAMA Network Open [Category] SARS, 치료기술, [키워드] activities Adults affected age Ageusia Analysis Anosmia association Brazil case report form center Characteristics clinical Clinical data clinical feature Clinical research conducted Connecticut COVID cross-sectional Determining develop Diagnosis dysfunction evaluated had more headache highest hygiene Hyposmia impairment Logistic regression Long neurologic Occurrence Odds ratio olfactory dysfunction onset of symptoms outcome outpatients Patient patients persistent Potential treatment Prevalence Prognosis questionnaire rehabilitation sense of smell severity significantly sleep disorder Sociodemographic Symptom Symptoms symptoms of COVID-19 the study group was recorded women [DOI] 10.1001/jamanetworkopen.2022.30637 PMC 바로가기
Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS-CoV-2?Article Published on 2022-09-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Anti-inflammatory antioxidant antiviral properties cell proliferation changes COVID-19 Effect Evidence hesperetin hesperetin. host cell host cells Inflammatory response Inflammatory responses Interaction involved molecular mechanism pathogenesis of SARS-CoV-2 pathway pharmacological PI3K/AKT Potential treatment protein synthesis Replication SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection signaling pathway subsequent therapeutic effect viral entry Viral particles [DOI] 10.1111/jfbc.14212 PMC 바로가기