Can Clinical Symptoms and Laboratory Results Predict CT Abnormality? Initial Findings Using Novel Machine Learning Techniques in Children With COVID-19 InfectionsMedicine Published on 2021-06-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Accuracy age approved artificial intelligence AUC C-reactive protein Can Cancer Chest CT children clinical Clinical data clinical symptom collected coronavirus 2019 disease costly COVID-19 COVID-19 patients decision trees determine ferritin finding global public health incidence indicated laboratory result Local lymphocyte machine learning machine learning model manifested Neutrophils novel outcome outcomes pediatric Pediatric patient Pediatric patients performed positive RT-PCR powerful tool predict Prognosis question Result RT-PCR—polymerase chain reaction with reverse transcription sensitivity shown Spread Support technique treated Wuhan [DOI] 10.3389/fmed.2021.699984 PMC 바로가기 [Article Type] Medicine
Nucleic Acid Testing of SARS-CoV-2SARS-CoV-2의 핵산 테스트Review Published on 2021-06-072022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Accuracy acid amplification caused Chain Reaction coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis CRISPR develop Diagnostic method diagnostic methods diagnostics digital PCR focus Genome sequencing high accuracy highlight isothermal amplification Loop-mediated isothermal amplification Metrology molecular Nanotechnology Next-generation sequencing NGS nucleic acid Nucleic acid detection nucleic acid testing outbreak PCR polymerase polymerase chain polymerase chain reaction powerful tool Reference materials resource reverse transcription Reverse transcription-polymerase chain reaction RT-LAMP RT-PCR RT-RPA SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 nucleic acid testing SARS-CoV-2 RNA sensitivity Standardization Testing virus [DOI] 10.3390/ijms22116150 PMC 바로가기 [Article Type] Review
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection단백질체 분석은 RNA 헬리카제 DDX3X를 SARS-CoV-2 감염에 대한 숙주 표적으로 식별합니다.Article Published on 2021-06-012022-09-11 Journal: Antiviral Research [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제, [키워드] accumulate aggregate antiviral drugs antiviral therapeutics cellular characterization COVID-19 cytoplasmic DDX3X DEAD RNA helicase develop eIF2α foci G3BP1 granules Health Helicase Host host protein host proteins Host-directed therapies identify infected cell infected cells infected Vero E6 cells Infection involved life cycle metabolism mitigate nucleoprotein Phosphorylation powerful tool Protein proteomic Proteomic analysis proteomics reduce Replication required ribonucleoprotein RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 replication scaffold proteins significantly small interfering RNAs small molecule Small molecules Stress stress granule stress granules Structure the SARS-CoV-2 Therapeutic strategies therapeutic strategy translation upstream Vero E6 VERO E6 cells Viral viral replication Viral RNA virus viruses [DOI] 10.1016/j.antiviral.2021.105064 PMC 바로가기 [Article Type] Article
Evaluation of a Pseudovirus Neutralization Assay for SARS-CoV-2 and Correlation with Live Virus-Based Micro Neutralization AssayArticle Published on 2021-05-302022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Accuracy biosafety can be used coronavirus COVID-19 diagnostic effective epidemiological studies evaluate evaluated human serum Infection lab Laboratory lentiviral micro-neutralization assay microneutralization negative sample Neutralization assay Neutralizing neutralizing antibody outbreak Particle Pneumonia positive positive sample powerful tool provide pseudotype pseudotyped viral particle reported Safe SARS-CoV-2 Saudi Arabia sensitivity serology specificity Testing the Spike viral particle virus virus neutralization assay viruses was used wild-type Wuhan [DOI] 10.3390/diagnostics11060994 PMC 바로가기 [Article Type] Article
Predict Score: A New Biological and Clinical Tool to Help Predict Risk of Intensive Care Transfer for COVID-19 PatientsArticle Published on 2021-05-182022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] age Analysis baseline Biological biological parameter biological parameters Biology Body C-reactive protein clinical Cohort composed COVID-19 COVID-19 crisis COVID-19 patient develop health care systems Hospitalization Hospitalized identify independent variable index intensive care lactate dehydrogenase limitation Marseille mass multivariate neutrophil–lymphocyte ratio New oxygen saturation Patient performed powerful tool Rate recruited respiratory risk score strained treated university validation cohort [DOI] 10.3390/biomedicines9050566 PMC 바로가기 [Article Type] Article
A multi‐class COVID‐19 segmentation network with pyramid attention and edge loss in CT imagesOriginal Research Paper Published on 2021-05-042022-10-30 Journal: Iet Image Processing [Category] COVID-19, [키워드] Accuracy assist Automatic auxiliary coefficient consolidation contagiousness Convolution COVID‐19 dataset diagnose Diagnosis effective evaluated experiment feature ground glass opacities IMPROVE include Infection information interstitial lung Novel coronavirus outperform positive powerful tool promote severity similarity Symptom the disease [DOI] 10.1049/ipr2.12249 PMC 바로가기 [Article Type] Original Research Paper
Risk-Based Monitoring in Clinical Trials: Past, Present, and Future임상 시험의 위험 기반 모니터링: 과거, 현재 및 미래Analytical Report Published on 2021-04-292022-09-10 Journal: Therapeutic innovation & regulatory science [Category] MERS, SARS, 치료기술, [키워드] ACRO adoption approach clinical Clinical research clinical trial collected component conducted COVID-19 pandemic data integrity deviation Effectiveness Future greater highlighting implementation KRIs monitoring organization pandemic patient safety powerful tool present promote protocol ranged RBM reduced reduction in risk site monitoring Support switching Trial trials [DOI] 10.1007/s43441-021-00295-8 PMC 바로가기 [Article Type] Analytical Report
Digital cognitive behavioral therapy for insomnia promotes later health resilience during the coronavirus disease 19 (COVID-19) pandemicRandomized Controlled Trial Published on 2021-04-092022-10-05 Journal: Sleep [Category] SARS, 임상, [키워드] Analysis CBT-I clinical cognitive cognitive-behavioral therapy condition contribute control condition coronavirus disease COVID COVID-19 COVID-19 pandemic COVID-related stress Depression Digital Digital health Engagement evaluate the effect evaluated event events Evidence Health individual Insomnia Intervention less Mental mental health Mild moderate pandemic physical powerful tool prevention primary care promote Randomized controlled trial Regression reported Resilience risk severe depression significantly Stress stressors subsequent Symptom Symptoms therapy Trial were assessed were used with COVID-19 [DOI] 10.1093/sleep/zsaa258 PMC 바로가기 [Article Type] Randomized Controlled Trial
Deep Mutational Scanning of Viral Glycoproteins and Their Host ReceptorsMolecular Biosciences Published on 2021-04-092022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] assist cell entry changes in circulating contribute Critical deep deep mutagenesis deep mutational scan deep sequencing Effect entry receptor escape mutation glycoprotein help host cell Host immune response host receptor humoral immunogen in vitro interactions Laboratory less membrane fusion Mutation mutational landscape Neutralizing neutralizing antibody powerful tool protective immunity protein interactions protein sequence receptor residue scanning Selection sequence target variant viral escape viral fusion protein viral glycoprotein viral glycoproteins viral spike virus Virus spike virus strains while [DOI] 10.3389/fmolb.2021.636660 PMC 바로가기 [Article Type] Molecular Biosciences
Self-sampling of capillary blood for SARS-CoV-2 serologySARS-CoV-2 혈청학을 위한 모세혈관 자가 샘플링Article Published on 2021-04-082022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI analysed Analysis antibody Blood blood collection capillary capillary blood capillary blood samples Cohen’s kappa coefficient collected Concordance COVID-19 detect Diagnosis Dried blood spots eight Epidemiology feasible Filter Paper heparin IgG ELISA immune response immunology Infectious diseases Laboratory Large-scale testing Lateral flow tests lithium Lithium heparin nine not affect participant plasma powerful tool reference standard room temperature SARS-CoV-2 sensitivity serological assessment Serological testing serology storage temperature Transmission venepuncture venous venous blood viral infection [DOI] 10.1038/s41598-021-86008-5 PMC 바로가기 [Article Type] Article