Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart TissuesArticle Published on 2022-10-012022-11-15 Journal: Advanced Science [Category] 신약개발, 치료제, [키워드] antiviral drugs approved drugs ATP2A2 cardiotoxic effect Cardiotoxicity cell death Clinical data clinical trial clinically concentrations contractile Coronavirus disease 2019 COVID-19 demonstrated drug drug candidate drug treatments dysregulation effective engineered heart tissue evaluate expression of gene fumarate handling HCN4 heart heart tissue High Throughput Screening Human human pluripotent stem cell-derived cardiomyocytes induced ion homeostasis limit MYH6 Patient powerful tool regulate Remdesivir Repurposed drug repurposed drugs for COVID-19. reveal Ritonavir RNA-seq analysis significantly Spread STEM therapy TNNT2 [DOI] 10.1002/advs.202203388 PMC 바로가기
Nanoelectrokinetic-assisted lateral flow assay for COVID-19 antibody testCOVID-19 항체 검사를 위한 나노전자동력학 보조 측류 분석Article Published on 2022-09-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] 2019 acute respiratory syndrome analytical sensitivity antibody Antigen Biomarker Biomarkers Combination coronavirus coronavirus disease COVID-19 COVID-19 antibody test COVID-19 pandemic diagnostic disease Endemic Immunoglobulin Immunoglobulin G increase in Lateral lateral flow lateral flow assay limit of detection offer platform POCT point-of-care powerful tool Preconcentration provide respiratory SARS-CoV-2 SARS-CoV-2 IgG screening tests self-testing sensitivity serum samples severe acute respiratory syndrome Coronavirus virus titer virus titers [DOI] 10.1016/j.bios.2022.114385 PMC 바로가기 [Article Type] Article
SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applicationsArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] antibodies antibody B.1.1.529 B.1.617.2 camelid heavy-chain-only antibodies candidate caused characterized Combination Concentration COVID-19 pandemic Delta detect detection antibody diagnostic diagnostics domain ELISA enzyme-linked immunosorbent assays Evolution expressed FIVE full length IgG2 in vitro naïve nanobodies neutralization neutralized Neutralizing neutralizing capacity omicron Particle performed potential therapy powerful tool Protein pseudotyped Pseudotyped virus SARS-CoV-2 selected shown single domain antibodies. specificity spike the SARS-CoV-2 therapeutic variant variants of concern virus Virus-like particle virus-like particles wildtype [DOI] 10.3389/fimmu.2022.930975 PMC 바로가기
Photochemical Identification of Auxiliary Severe Acute Respiratory Syndrome Coronavirus 2 Host Entry Factors Using μMapArticle Published on 2022-09-142022-11-16 Journal: Journal of the American Chemical Society [Category] SARS, 변종, [키워드] ACE2 ACE2 expression acute respiratory syndrome auxiliary cell entry complex coronavirus coronavirus 2 COVID-19 pandemic Critical Delta eight engage ENhance enzyme expression facilitate Factor Genetic Host human cell identification identify identifying labeling lymphocyte membrane fusion pathophysiology platform powerful tool Protein receptor receptors respiratory SARS-CoV-2 significantly spike variant systemically the spike protein tissues transmembrane serine protease viral entry Wuhan [DOI] 10.1021/jacs.2c06806 PMC 바로가기
Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central PennsylvaniaArticle Published on 2022-09-012022-11-16 Journal: Journal of environmental quality [Category] 치료기술, [키워드] acute respiratory syndrome affected analyzed Antibiotics Area authority calculated collected Concentration concentrations connection coronavirus COVID-19 pandemic Dexamethasone doxycycline effective explained facility FIVE Health highlight hospitalized patient Hydroxychloroquine Impact Medicine no correlation occurred pandemic patients with COVID-19 persistence plant plants powerful tool Quotient Reclamation Remdesivir returned reuse risk Sample state Surveillance therapeutic agent treated Treatment university utility Variation virus water with COVID-19 would increase [DOI] 10.1002/jeq2.20398 PMC 바로가기
Central carbon metabolism remodeling as a mechanism to develop drug tolerance and drug resistance in Mycobacterium tuberculosisArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘, [키워드] accumulating acquisition adaptive antibiotic Antibiotic resistance Antibiotics biochemical carbon metabolism catalytic catalytic shift Combination COVID-19 outbreak develop drug regimen drug resistance drug tolerance drug-resistant Efficacy etiological agent Evidence facilitate Genetic identify Infection Infectious disease intrinsic mechanism metabolomics molecular basis molecular mechanism Mycobacterium tuberculosis phenotypic Population populations powerful tool provide regimen susceptible target thought Tolerance Treatment Tuberculosis unique [DOI] 10.3389/fcimb.2022.958240 PMC 바로가기
Advancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 20212021년 독일에서 중증 급성 호흡기 증후군 코로나바이러스 2의 분자 및 게놈 감시를 통한 정밀 백신학 발전Article Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 유전자 메커니즘, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Advancing Alpha variant Analysis approach Beta collected complement Comprehensive contributed coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 dataset deceleration Delta wave Effectiveness effort estimate Evolution expansion facilitated Genetic genomic genomic sequencing Genomic surveillance Germany GISAID immune evasion in vitro incidence incidence estimation indicated Laboratory molecular molecular surveillance Multiple multiple mutations Mutation National neutralization assays observation period pathogen pathogen genomics Phylogenetic analysis powerful tool Precision Public public health Randomly respiratory resulting Robert Koch SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic surveillance sequence sequenced sample Spread Surveillance the SARS-CoV-2 undergo vaccination Vaccination strategies Vaccination strategy Vaccine variant variant of concern variants of concern virus whole-genome sequencing [DOI] 10.1093/cid/ciac399 PMC 바로가기 [Article Type] Article
A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samplesCRISPR 기반 초고감도 분석은 임상 샘플에서 SARS-CoV-2 항체의 원자 농도를 감지합니다.Article Published on 2022-08-092022-09-11 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antibody detection classic clinical clinical sample clinical samples Clinical use clinically collected Concentration CRISPR detect diagnostics General population homogeneous immunoassay immunoassays kidney transplant recipient Laboratory large cohort nucleic acid Nucleic acid detection nucleic acids point-of-care powerful tool Proteins Quantitative analysis SARS-CoV-2 antibody sensitivity serum serum sample serum samples shown simplicity specificity translate [DOI] 10.1038/s41467-022-32371-4 PMC 바로가기 [Article Type] Article
Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy Research Published on 2022-08-012022-10-05 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] approach association automatically Clinical data Combination complex Consensus COVID-19 severity disease severity Electronic health record Genetic genomes highest highlight HLA host genome impacted individual marker metagenomic Nasopharyngeal swab neurologic pandemic phenotype Population positive powerful tool Region reported reveal risk SARS-CoV-2 SARS-CoV-2 pandemic sequence severe COVID-19 susceptibility Transcriptome viral disease viral genome [DOI] 10.1038/s41467-022-32397-8 [Article Type] Research
A metagenomic DNA sequencing assay that is robust against environmental DNA contamination환경 DNA 오염에 강한 메타게놈 DNA 시퀀싱 분석Article Published on 2022-07-212022-09-11 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] applied Blood Co-infection Contamination COVID-19 DNA DNA sequencing identify Infection Inflammatory bowel disease introduced Isolation lAbel metagenomic metagenomic sequencing microbial Microbial communities microbial community Microbiome microorganism microorganisms powerful tool recorded robust Sepsis Sequencing SIFT Tagging Urine [DOI] 10.1038/s41467-022-31654-0 PMC 바로가기 [Article Type] Article