Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicityArticle Published on 2022-02-082022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] alcohol antioxidant Apoptosis bone marrow failure Caenorhabditis elegan Cancer metabolism cause cellular cellular damage Chemical genetics coding contributing to crosslinking cytotoxicity DNA DNA damage DNA repair endogenous enzyme formaldehyde functional GSH human cell Mechanisms of disease metabolic pathways metabolite Mutation oxidative stress Patient prevented PROTECT question raising Redox imbalance reduced resulting syndrome Therapeutic benefit thiol group thought Toxicity Trigger underlie yielding [DOI] 10.1038/s41467-022-28242-7 PMC 바로가기 [Article Type] Article
Impact of Safety Nets on Household Coping Mechanisms for COVID-19 Pandemic in MalawiPublic Health Published on 2022-02-072022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] activities activity affecting assist Cash complement coping COVID-19 COVID-19 Africa COVID-19 Malawi COVID-19 urban cash intervention Malawi Effect Evidence finding Government had no health economics health policy Malawi household Impact indicated introduced investigated less mechanism Model non-recipients organization pandemic Panel positive prevented public policy Malawi receiving recipient reduce reducing respond Result Safety safety nets scaled up Shock social protection programs Malawi Support survey urban Volume [DOI] 10.3389/fpubh.2021.806738 PMC 바로가기 [Article Type] Public Health
Effectiveness and Safety of COVID-19 Vaccine among Pregnant Women in Real-World Studies: A Systematic Review and Meta-AnalysisSystematic Review Published on 2022-02-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 95% CI adverse event Analysis coronavirus disease Coverage COVID-19 COVID-19 vaccination COVID-19 vaccine Effectiveness fetal Hospitalization IMPROVE Meta-analysis Neonatal observational study outcomes Policy Pregnancy pregnant pregnant women prevented reduce review risk of infection Safety SARS-COV-2 infection searched systematic review vaccination Vaccine [DOI] 10.3390/vaccines10020246 PMC 바로가기 [Article Type] Systematic Review
Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial초기 무증상 SARS-CoV-2 감염에서 증상이 있는 COVID-19 발병에 대한 피하 카시리비맙 및 임데비맙 항체 조합 대 위약의 효과: 무작위 임상 시험Clinical Trial Published on 2022-02-012022-09-12 Journal: JAMA [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 1:1 age anti-SARS-CoV-2 antibody combination Asymptomatic asymptomatic infection baseline Casirivimab clinical Combination Contact COVID-19 development dose double-blind Effect Efficacy efficacy analysis efficacy end point eligible enrolled evaluate the effect event Follow-up household contact Imdevimab incidence index case individual Odds ratio outcome participant phase 3 trial Placebo placebo-controlled polymerase chain positive Positive test Prevent prevented primary end point progression proportion Randomized receive receiving reduce reduced reduction in reported Result risk Romania RT-qPCR SARS-CoV-2 SARS-COV-2 infection seronegative seronegative participant significantly Subcutaneous symptom duration symptomatic symptomatic disease symptomatic participant symptomatic SARS-CoV-2 infection Treatment treatment-emergent adverse event Viral load women [DOI] 10.1001/jama.2021.24939 PMC 바로가기 [Article Type] Clinical Trial
Viral Interference between Respiratory VirusesPerspective Published on 2022-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome airway epithelial cell animal model antagonistic cellular circulation coronavirus coronavirus disease COVID-19 demonstrated ENhance evaluated expected Host human metapneumovirus Human rhinovirus Immunity in viral infect Infection Influenza virus Innate immunity Interaction interactions Interference interferon Intervention involved lifted mechanism Multiple nonspecific offer pandemic positive prevented reduce Replication respiratory respiratory infections respiratory syncytial virus respiratory tract respiratory virus respiratory viruses resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 susceptible synergistic the interferon viral interference virus viruses zoonoses [DOI] 10.3201/eid2802.211727 PMC 바로가기 [Article Type] Perspective
All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐κB Signaling PathwayImmunology Published on 2022-01-312022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] acid Activation all-trans retinoic acid anti-inflammatory activity ATRA attenuate Cell cells damaged downregulated downstream economic loss epithelial epithelial cell gastroenteritis IL-1β IL-6 IL-8 immunomodulatory properties indicated Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibiting inhibitor Injury intestinal intestinal inflammation IPEC-J2 cells damage knockdown MAVS MDA5 mechanism molecular mechanism mRNA abundance mRNA expression NF-κB nuclear translocation occludin p65 Pathogenesis Phosphorylation prevented pro-inflammatory cytokines protective effect protein level reduced reduction resulting reversed RIG-I RLRs/NF‐κB pathway signaling molecule signaling pathway significantly Suppressing TGEV TLR3 TLR7 TNF-α Traf6 transmissible gastroenteritis virus Treatment TRIF triggered upregulation ZO-1 [DOI] 10.3389/fimmu.2022.734171 PMC 바로가기 [Article Type] Immunology
Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposingResearch article Published on 2022-01-292022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, [키워드] ACE2-binding site Alpha Analysis binding binding site Binding site similarity conserved Course COVID-19 defined demonstrated distal docking drug experiment identify IL-6 IL-6 expression immune cells Infection inhibitor mechanism molecular dynamics molecular dynamics simulations Montelukast neutralization predicted prevented Protein RBD receptor Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants structural modeling the disease the RBD the SARS-CoV-2 variant [DOI] 10.1016/j.csbj.2022.01.024 [Article Type] Research article
Training Plan for the Continuity of Non-Presential Education in Six Peruvian Universities during COVID-19Article Published on 2022-01-292022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] activities carried Community continuity courses COVID-19 Diagnosis digital competence dimension dimensions education higher education institutions limitation National offered pandemic plan prevented resource Support synchronous techno-pedagogical design training tutorial support university Virtual training [DOI] 10.3390/ijerph19031562 PMC 바로가기 [Article Type] Article
Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants칸나비노이드는 SARS-CoV-2 및 새로운 변이체의 세포 진입을 차단합니다Article Published on 2022-01-282022-09-11 Journal: Journal of natural products [Category] Coronavirus, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affinity Alpha Alpha variant B.1.1.7 B.1.351 Beta variant block cannabinoid cannabinoids cannabis cells complement Coronavirus-2 COVID-19 effective epithelial cells expressing Follow-up hemp human epithelial cell human epithelial cells Infection Ligand live SARS-CoV-2 mass spectrometry Prevent prevented pseudovirus Safe SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein the SARS-CoV-2 the spike protein therapeutic agent treat Vaccines variant variants virus neutralization assays was used [DOI] 10.1021/acs.jnatprod.1c00946 PMC 바로가기 [Article Type] Article
Impact of vaccination on the COVID-19 pandemic in U.S. states미국 주에서 예방 접종이 COVID-19 전염병에 미치는 영향Article Published on 2022-01-282022-09-10 Journal: Scientific Reports [Category] 변종, 치료법, [키워드] Combination COVID-19 COVID-19 pandemic COVID-19 vaccination death rates delta variant early stage Effectiveness effort evaluated faster herd immunity Hospitalization Immunity Impact IMPROVE Infection infection rate mass vaccination Novel coronavirus pandemic path percentage points predict predicted prevented public health reduced vaccination Vaccine Vaccine hesitancy viral infection [DOI] 10.1038/s41598-022-05498-z PMC 바로가기 [Article Type] Article