Mesenchymal stromal cell-derived extracellular vesicles reduce lung inflammation and damage in nonclinical acute lung injury: Implications for COVID-19Research Article Published on 2021-11-152022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute lung injury administration alveolar-capillary barrier caused Cell cell death cells cellular contribute COVID-19 cytokine disease distress dose dysfunction effective Evidence extracellular vesicle Health immune modulation impairing Inflammation Injury lung Lung inflammation mesenchymal stem cell Particle Pathogenesis pathology pro-inflammatory pro-inflammatory cytokine pulmonary epithelial cell RBD Receptor binding domain reduce reduced response SARS-CoV-2 secretion Signaling surface protein the SARS-CoV-2 therapeutic potential translation Treatment [DOI] 10.1371/journal.pone.0259732 PMC 바로가기 [Article Type] Research Article
Effects of β-Blockers on the Sympathetic and Cytokines Storms in Covid-19Immunology Published on 2021-11-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activate Activation acute lung injury acute respiratory distress acute respiratory syndrome affected Anti-inflammatory anti-inflammatory effect antibody ARDS B-cell Beta blockers carotid chemosensory Complication coronavirus coronavirus disease cross Cytokine storm Effect exaggerated immune response hypoxia Inflammation Interaction Invasion macrophage activation management manifestation mitigate MOF multi-organ failure NF-κB oxidative stress pandemic pathway patients pharmacology and Covid potential mechanism pro-inflammatory cytokine pro-inflammatory cytokines Prospective Study reduction respiratory SARS-CoV-2 SARS-COV-2 infection Severe case signaling pathway storm sympathetic storm syndrome the SARS-CoV-2 Trigger virus β-blocker [DOI] 10.3389/fimmu.2021.749291 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVSImmunology Published on 2021-11-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activating Activation attenuate Calu-3 caused cells clinical study COVID-19 cytokine cytokine expression cytokine production effector ENhance expression IL-1β IL-2 IL-6 increase induce infected with SARS-CoV-2 Infectious disease inhibitor investigated knockdown MAVS molecular mechanism NF-κB NF-κB NF-κB activation NF-κB signaling nsp5 overexpression pathway Patient pro-inflammatory cytokine promote Protein protein level Research SARS-CoV-2 SARS-COV-2 infection stability SUMOylation the disease TNF-α Treatment triggering upstream [DOI] 10.3389/fimmu.2021.750969 PMC 바로가기 [Article Type] Immunology
Vitamin D Serum Levels in Subjects Tested for SARS-CoV-2: What Are the Differences among Acute, Healed, and Negative COVID-19 Patients? A Multicenter Real-Practice StudySARS-CoV-2 검사 대상자의 비타민 D 혈청 수준: 급성, 치유 및 음성 COVID-19 환자의 차이점은 무엇입니까? 다기관 실제 실습 연구Comparative Study Published on 2021-11-032022-09-10 Journal: Nutrients [Category] MERS, 바이오마커, 진단, [키워드] acting acute COVID-19 administration Admission circulating correlation COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cytokine deficiency difference dropped evaluate Evidence Gender Gender difference Healed IL-6 IL-6 levels Infection interleukin-6 Level lowest male manifested metabolite multicenter negative non-infected Patient patients pro-inflammatory cytokine recruited reported SARS-CoV-2 secondary endpoint serum Serum level serum levels significant increase significantly lower statistically significant difference subject subjects subset tested three group three groups Vitamin D vitamin D deficiency Vitamin D3 [DOI] 10.3390/nu13113932 PMC 바로가기 [Article Type] Comparative Study
SARS-CoV-2 Antibodies Mediate Complement and Cellular Driven InflammationSARS-CoV-2 항체는 보체 및 세포 유발 염증을 매개합니다Immunology Published on 2021-11-022022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Activation acute respiratory syndrome Antibody Response C1q caused cell line cellular characterized classical Combination complement Complement pathway component consequence convalescent individual coronavirus coronavirus disease correlated COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity disease severity distribution domain driven by Effect ELISAs exacerbating IgG IgG level IgG response IgG subclasse IgG1 IgG3 individual Inflammatory response Ligand monocyte Monocytes natural infection outcome pandemic plasma priming pro-inflammatory cytokine public health threat question RBD receptor Receptor binding domain receptor engagement risk SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody secretion severe disease significantly spike subsequent the antibody response the SARS-CoV-2 THP-1 TNF-α viral infection viral neutralization were used [DOI] 10.3389/fimmu.2021.767981 PMC 바로가기 [Article Type] Immunology
C-reactive protein as an effector molecule in Covid-19 pathogenesisCovid-19 발병 기전에서 이펙터 분자로서의 C 반응성 단백질Article Published on 2021-11-012022-09-11 Journal: Reviews in Medical Virology [Category] SARS, 바이오마커, 임상, [키워드] activate Affect affected Apoptosis article Asymptomatic C-reactive protein C-reactive protein (CRP caused clinical trials complement contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 immunity CRP CRP level CRP levels Cytokines damage database decrease died disease drug evaluated Evolution Factor immune system Immunity induce Inflammatory response inflammatory status involved molecules organ system organ systems outcome pandemic Pathogenesis Patient pro-inflammatory cytokine pro-inflammatory cytokines Randomized SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection severe evolution. systematic review the disease Treatment virus virus infection was performed [DOI] 10.1002/rmv.2221 PMC 바로가기 [Article Type] Article
Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hCMEC/D3 brain endothelial cells저산소증은 hCMEC/D3 뇌 내피 세포에서 ACE2 및 TMPRSS2 SARS-CoV-2 세포 진입 매개체의 발현을 변경합니다Article Published on 2021-11-012022-09-11 Journal: Microvascular research [Category] SARS, 유전자 메커니즘, [키워드] accompanied ACE2 ACE2 mRNA acute respiratory syndrome coronavirus Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) blood-brain barrier Blood-brain barrier (BBB) Blot Brain Cell cell entry changes in Control control group coronavirus 2 COVID19 decrease Effect endothelial Endothelial cell endothelial cell damage endothelial cells enzyme expression expression of SARS-CoV-2 Factor followed by groups Human Human brain Human cerebral microvascular endothelial cells (hCMEC/D3) hypoxia hypoxic hypoxic condition identify IL-6 in vitro induce interleukin interleukin 6 marker mechanism mRNA Neurological complication Neurological complications oxygen pro-inflammatory cytokine protease Protein protein expression qPCR receptor reduced regulate replicated respiratory SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subsequent susceptibility TMPRSS2 TMPRSS2 expression TMPRSS2 protein transmembrane transmembrane protease serine 2 transmembrane protease serine 2 (TMPRSS2) von Willebrand factor western blot [DOI] 10.1016/j.mvr.2021.104232 PMC 바로가기 [Article Type] Article
Dynamics of Inflammatory Markers in Predicting Mortality in COVID-19Internal Medicine Published on 2021-10-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI analyzed baseline biochemical Characteristics conducted coronavirus disease COVID-19 COVID-19 India CRP cut-off Cytokine storm Department determine Dynamics ferritin Final higher risk IL-6 India inflammatory biomarkers Inflammatory marker lactic acid Logistic regression analysis marker Medical Sciences Medicine morbidity and mortality Mortality Mortality predictors multivariate New outcome outcome predictors in covid-19 outcomes Patient patients with COVID-19 pro-inflammatory cytokine Probability procalcitonin prognostic Protein Result Retrospective study sensitivity specificity statistically significant was done with COVID-19 [DOI] 10.7759/cureus.19080 PMC 바로가기 [Article Type] Internal Medicine
Traditional Chinese Medicine, Qingfei Paidu Decoction and Xuanfei Baidu Decoction, Inhibited Cytokine Production via NF-κB Signaling Pathway in Macrophages: Implications for Coronavirus Disease 2019 (COVID-19) TherapyPharmacology Published on 2021-10-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] A549 cell A549 cells Activation addition analyzed anti-inflammatory activity Baidu Cell chemokine Chinese COVID-19 Cytokine storm Decoction defined demonstrated Efficacy ELISA evaluated expression expression level feature host immunity IFN IFN signaling pathway IFNα and IFNβ immune response in vitro infected with SARS-CoV-2 inhibited Innate immunity interferon-stimulated gene interleukin-6 investigated ISGs IκBα Ligand LPS Macrophage macrophage polarization macrophages marker mechanism Medicine modulation monocyte chemotactic protein-1 network pharmacology neutral red NF-κB signaling pathway NF-κB NF-κB signaling p65 pathway Patient PCR Phosphorylation pro-inflammatory pro-inflammatory cytokine Production Regulation robust RT-qPCR SARS-CoV-2 shown signaling pathway significantly suppressed THP-1 Traditional Traditional Chinese medicine treated Treatment tumor necrosis factor-α type 1 interferon were measured [DOI] 10.3389/fphar.2021.722126 PMC 바로가기 [Article Type] Pharmacology
Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung CellsPharmacology Published on 2021-10-252022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accompanied Affect Anti-inflammatory Antiviral antivirals assessment Calu-3 Calu-3 cell candidate CCL5 CD40L cell line cellular entry chemokine clinical study comparable Concentration coronavirus CoV COVID-19 COVID-19 therapeutics CXCL10 CXCL9 cytokine cytokine secretion Cytokine storm derivatives disease drug Duration of infection Effect elevated exhibited Extract fraction growth growth factor highly pathogenic Human human lung IC50 IL-13 IL-1β IL-6 IL-8 IL1B IL6 immune immunomodulatory function immunomodulatory properties in vitro in vivo Inflammatory response inhibited inhibiting innate immune response MERS-CoV modulation non-toxic oligomerization Particle PDGF Pelargonium pelargonium root extract (EPs® 7630) Phytomedicine Post-infection pro-inflammatory cytokine pro-inflammatory gene Prodelphinidin pseudovirus purine reduced reducing Regulation root SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 propagation separated shown significantly symptom severity TNF-α TNFAIP3 upper respiratory upregulation Viral load viruses [DOI] 10.3389/fphar.2021.757666 PMC 바로가기 [Article Type] Pharmacology