Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR Research Published on 2022-06-132022-10-05 Journal: Nature biotechnology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] Activation Antigen-specific T cells antigens breakthrough infections Cell cellular immunity chemokine correlated CXCL10 expression functional helping IFN-γ Immunity magnitude Messenger RNA monocyte mRNA normalized PCR populations protective immune response quantification quantitative PCR Rapid revaccination risk RNA extraction SARS-CoV-2 SARS-CoV-2 viral secrete stimulate T cell T cell activation [DOI] 10.1038/s41587-022-01347-6 [Article Type] Research
A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort studyResearch article Published on 2022-06-092022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 임상, [키워드] accelerate Accuracy agency APACHE II assessment Berlin Biomarker Biomarkers Charité clinical clinical disease progression Clinical outcome clinical risk clinical trials Cohort conducted Council COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 severity death Dexamethasone disease prognosis disease severity education ERC European finding foundation funding Germany hallmark Healthcare system healthy individuals help hospitalised introduced LC-MS/MS LLOQ machine learning median Medicine Mild Mobility moderate multiplex node observational study outcome Patient patient cohort patients with COVID-19 peptide peptides predicted Prognosis Prognostic value Protein proteomics quantification Registered registry Research resource SARS-CoV2 Science sensitivity severe COVID-19 severity Severity stratification SOFA Spectrometry Standard of care stratified Support supported survival System targeted proteomics the median the WHO Therapies Treatment Wellcome Trust [DOI] 10.1016/j.eclinm.2022.101495 [Article Type] Research article
Deep learning-based lesion subtyping and prediction of clinical outcomes in COVID-19 pneumonia using chest CT Research Published on 2022-06-072022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 95% confidence interval Admission AUC automatically average calculated Chest CT Clinical outcome clinical outcomes clinically Cohort collected COVID-19 CT scans deep deep learning develop Dice disease severity evaluate evaluated ICU intensive care unit Interpretation lung mechanical ventilation Metrics Negative predictive value outcome overlapping parenchymal damage patient mortality patients Pneumonia Positive predictive value predict quantification quantitative assessment Segmentation sensitivity severity Spearman correlation coefficient specificity subtype tested was used [DOI] 10.1038/s41598-022-13298-8 [Article Type] Research
Anti-SARS-CoV-2 antibody response after 2 and 3 doses of BNT162b2 mRNA vaccine in patients with lymphoid malignancies림프성 악성종양 환자에서 BNT162b2 mRNA 백신 2회 및 3회 투여 후 항-SARS-CoV-2 항체 반응Article Published on 2022-06-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected anti-CD20 Anti-CD20 antibodies Anti-CD20 antibody anti-CD38 anti-RBD Anti-RBD IgG antibody antibody concentration Antibody concentrations Antibody Response B-cell malignancies B-cell malignancy benefit binding domain booster Cell Cohort Concentration conducted Course COVID-19 COVID-19 patient COVID-19 patients disorders dose effective evaluate haematological malignancies haematological malignancy Haematologicalmalignancies humoral Humoral response humoral responses IgG Immunocompromised increment IQR lymphoid lymphomas malignancies malignancy median monoclonal Mortality mRNA vaccination mRNA vaccine of BNT162b2 Patient patients patients treated plasma Plasma cell Prophylaxis quantification RBD SARS-CoV-2 Seroconversion seroconversion rate seroconverted serological serological response serology significantly spike the disease the vaccine therapy third dose Vaccine vaccine dose [DOI] 10.1016/j.cmi.2022.02.029 PMC 바로가기 [Article Type] Article
Monitoring COVID-19 through SARS-CoV-2 quantification in wastewater: progress, challenges and prospects폐수 내 SARS-CoV-2 정량화를 통한 COVID-19 모니터링: 진행 상황, 과제 및 전망Review Published on 2022-06-012022-09-11 Journal: Microbial Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] addressed approach approaches Concentration COVID-19 Efficiency Factor faster feasible Laboratory less limitation Local methodology MONITOR monitoring Moore Outbreaks parameter physical Population progression qPCR quantification regions risk SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant standardized protocols Swab temperature Treatment tropical Variation variations virus warm [DOI] 10.1111/1751-7915.13989 PMC 바로가기 [Article Type] Review
Favipiravir (SARS-CoV-2) degradation impurities: Identification and route of degradation mechanism in the finished solid dosage form using LC/LC-MS methodFavipiravir(SARS-CoV-2) 분해 불순물: LC/LC-MS 방법을 사용하여 완성된 고체 제형의 분해 메커니즘 식별 및 경로Article Published on 2022-06-012022-09-11 Journal: Biomedical chromatography : BMC [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetonitrile Analysis analyte approved buffer column temperature Compound concentrations condition country Degradation degradation impurities, favipiravir, LC/LC-MS, related substances, SARS-CoV-2, stability indicating. dosage Emergency use Favipiravir flow rate Forced harmonization HPLC identification injection International Conference LC-MS limit linear linearity mechanism Mobile molecular pathway performed physical Precision Quality control quantification reaction recovery study Research research and development robust SARS-CoV-2 SARS-CoV-2 patients separation stability Standard deviation stationary stationary phase stress conditions supported tablets temperature treat Volume water [DOI] 10.1002/bmc.5363 PMC 바로가기 [Article Type] Article
Cytokeratin 18 cell death assays as biomarkers for quantification of apoptosis and necrosis in COVID-19: a prospective, observational studyCOVID-19에서 세포자멸사 및 괴사의 정량화를 위한 바이오마커로서의 Cytokeratin 18 세포 사멸 분석: 전향적 관찰 연구Observational Study Published on 2022-06-012022-09-11 Journal: Journal of Clinical Pathology [Category] Coronavirus, COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] admitted patients Adult patients Apoptosis appear assays Biomarker blood sample Blood samples Care caspase cell damage cell death clinical trials collected Control controls COVID-19 COVID-19 patient COVID-19 patients cytokeratin discharged patients elevated emergency department enrolled enzyme epithelial epithelial cell estimation hospitalisation hospitalised hospitalised COVID-19 patients ICU admission independent predictor independent predictors Intact intensive care unit mechanism multivariable logistic regression Necrosis non-ICU Patient patients patients with COVID-19 presenting quantification relative contribution relative contributions respiratory respiratory symptom respiratory symptoms risk stratification SARS-CoV-2 severe disease sick therapeutic efficacy Trigger triggers Virology [DOI] 10.1136/jclinpath-2020-207242 PMC 바로가기 [Article Type] Observational Study
Covid Visual Assessment Scale (“Co.V.A.Sc.”): quantification of COVID-19 disease extent on admission chest computed tomography (CT) in the prediction of clinical outcome-a retrospective analysis of 273 patientsObservational Study Published on 2022-06-012022-10-05 Journal: Emergency Radiology [Category] COVID19(2023년), SARS, 임상, [키워드] 95%CI Admission age analyzed assessment Chest computed tomography Chest CT clinical outcomes Co.V.A.Sc. correlated CoVASc Covid Visual Assessment Scale COVID-19 COVID-19 adult patient COVID-19 disease COVID-19 patient cutoff value death demographics disease evaluate evaluated Gender hospital Hospitalization ICU admission In-hospital death in-hospital mortality independent radiologist Laboratory male management material Observational cohort study Patient predict Probability quantification radiologist retrieved retrospective Retrospective analysis ROC analysis scale score sensitivity single-center specificity Variability variable Visual [DOI] 10.1007/s10140-022-02034-4 PMC 바로가기 [Article Type] Observational Study
Monitoring of alcohol-based hand rubs in SARS-CoV-2 prevention by HS-GC/MS and electrochemical biosensor: A survey of commercial samplesHS-GC/MS 및 전기화학적 바이오센서에 의한 SARS-CoV-2 예방의 알코올 기반 손 문지름 모니터링: 상업용 샘플 조사Article Published on 2022-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료기술, [키워드] acidification addition agency alcohol Alcohol-based hand rubs alignment ANOVA ANOVA test approach average Chromatography comparable Control coronavirus 2 correlation COVID-19 data set determine diffusion electrochemical biosensor ethyl alcohol evaluated gas chromatography Gas chromatography. hand hygiene Health highlighting house hygiene identify indicated indication indications isopropyl alcohol limit limit of detection LoQ mass mass spectrometry methyl alcohol monitoring parameter propyl alcohol provided quantification reported respiratory Result SARS-CoV-2 screening method severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spectrometry statistically tested were assessed widespread [DOI] 10.1016/j.jpba.2022.114694 PMC 바로가기 [Article Type] Article
Automated amplification-free digital RNA detection platform for rapid and sensitive SARS-CoV-2 diagnosis빠르고 민감한 SARS-CoV-2 진단을 위한 자동화된 증폭이 필요 없는 디지털 RNA 검출 플랫폼Article Published on 2022-05-262022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료기술, [키워드] Accuracy Alpha automated automatically comparable Complete COVID-19 pandemic CRISPR Critical Diagnosis diagnostic enzyme genomic RNA magnetic bead omicron platform quantification RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants specimen Spread viral infection viral infections [DOI] 10.1038/s42003-022-03433-6 PMC 바로가기 [Article Type] Article