A Prospective Cohort Study in Nonhospitalized Household Contacts With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Symptom Profiles and Symptom Change Over Time중증 급성 호흡기 증후군 코로나바이러스 2 감염이 있는 입원하지 않은 가구 접촉에 대한 전향적 코호트 연구: 시간 경과에 따른 증상 프로필 및 증상 변화Article Published on 2021-10-052022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Asymptomatic asymptomatic infection asymptomatic infections Chain Reaction change characterized collected Community community. Contact Contact tracing contribute coronavirus coronavirus 2 COVID-19 COVID-19 symptoms described detectable disease enrolled Fever first positive household household contact household contacts Improved individual infection control laboratory-confirmed SARS-CoV-2 infection less median age Mild mild or asymptomatic infections mild symptoms nasopharyngeal specimen neurologic over PCR test polymerase chain polymerase chain reaction profile progression Prospective Public health interventions Recognition reported reported symptom resolved respiratory respiratory symptom respiratory symptoms rRT-PCR rRT-PCR test SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Symptom Symptoms tested time upper respiratory Utah Viral transmission [DOI] 10.1093/cid/ciaa1072 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development자연 발생 파이토케미칼로 코로나19의 SARS-CoV-2 스파이크 단백질 표적화: 약물 개발을 위한 in silico 연구Article Published on 2021-10-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] ACE2 ACE2 receptor ACE2 receptors addition ADME Analysis angiotensin Angiotensin-converting enzyme anti-SARS-CoV-2 approved attachment binding binding free energy cascade cell surface receptor class class I fusion protein complex Compound COVID-19 disease drug-likeness engage enzyme FDA Fisetin flavonoids flavonoids and non-flavonoids free energy fusion fusion protein glycoprotein hACE2 HCQ Host host cell host cell surface host cells Hydroxychloroquine in silico indication Infection internalization membrane fusion molecular molecular docking molecular docking studies Molecular docking study molecular dynamics performed phytochemicals pre-fusion provided quercetin receptor Recognition SARS-CoV-2 SARS-CoV-2 spike protein spike spike glycoprotein Spike protein suggested targeting the SARS-CoV-2 tissue tropism transition Trigger viral envelope viral infection virus [DOI] 10.1080/07391102.2020.1796811 PMC 바로가기 [Article Type] Article
COVID-19 and cancer screening in Scotland: A national and coordinated approach to minimising harm스코틀랜드의 COVID-19 및 암 검진: 피해를 최소화하기 위한 국가적이고 조정된 접근Article Published on 2021-10-012022-09-11 Journal: Preventive medicine [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] affected approach bowel Cancer Cancer screening cancers Care COVID-19 COVID-19 pandemic criteria decision diagnoses framework Health Impact Impact of pandemic indicate Infection prevention information Innovation Investment measure monitoring Monitoring impact National National Health Service new infection NHS pandemic participant Patient primary care problem Programmatic screening PROTECT provide provided Recognition restart Scottish Screening Screening restart Screening suspension. seeking subsequent Suspension [DOI] 10.1016/j.ypmed.2021.106606 PMC 바로가기 [Article Type] Article
Theoretical Analysis of S, M and N Structural Proteins by the Protein–RNA Recognition Code Leads to Genes/proteins that Are Relevant to the SARS-CoV-2 Life Cycle and PathogenesisGenetics Published on 2021-09-292022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] Biomarker block code computational method COVID-19 Critical cycle decrease Defense described epithelial Factor homeostasis Host host cell identified genes identify Immune homeostasis Immunity involved life lipid homeostasis membrane MET metabolomics molecular Pathogenesis PIKfyve plasma post-transcriptionally promote Protein protein-RNA recognition code Recognition regulate SARS-CoV-2 SARS-CoV-2 entry sequence Signaling the SARS-CoV-2 tissue tissue homeostasis virus wound healing XYLB [DOI] 10.3389/fgene.2021.763995 PMC 바로가기 [Article Type] Genetics
Recognition of Long-COVID-19 Patients in a Canadian Tertiary Hospital Setting: A Retrospective Analysis of Their Clinical and Laboratory CharacteristicsArticle Published on 2021-09-262022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Affect age Canada Care clinical clinician collected Comorbidities Consensus COVID-19 COVID-19 cohort COVID-19 group COVID-19 patient criteria demographic diagnose disease disease biomarkers distribution fatigue had more inclusion criteria Infectious disease Inpatient laboratory characteristics laboratory data Laboratory test Laboratory testing long-COVID long-haulers mechanical ventilation not differ Patient patients with COVID-19 positive predict presenting Prevent proportion Quality of life Recognition reported respirology retrospective Retrospective analysis SARS-CoV-2 supplemental oxygen Symptom syndrome Tertiary tested Toronto treat weakness [DOI] 10.3390/pathogens10101246 PMC 바로가기 [Article Type] Article
Evaluation of Twitter data for an emerging crisis: an application to the first wave of COVID-19 in the UKArticle Published on 2021-09-242022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] absence Algorithm analysed Analysis applied Applied mathematics approach approaches behavioural Computational science corpus COVID-19 COVID-19 pandemic death distribution entity Epidemiology First wave Government Health information methodology National nine outbreak pandemic PHE Precision Public Health England ranged Recognition reported spike subset Topic Vaccine Volume [DOI] 10.1038/s41598-021-98396-9 PMC 바로가기 [Article Type] Article
Pattern Recognition Proteins: First Line of Defense Against CoronavirusesImmunology Published on 2021-09-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress syndrome adaptive Adaptive immune response Affect affecting Against apoptotic cell ATH - atherosclerosis atherosclerotic lesions C-reactive protein C1q cardiovascular complication cardiovascular system caused clearance combination treatment complement Complication composed coronavirus Coronaviruses COVID- 19 COVID-19 COVID-19 disease death development Direct Effect enhancement global healthcare host’s immune system IgM antibodies immune Immunity Innate innate and adaptive IgM antibodies Innate immunity involved killing LINE lung novel coronavirus SARS-CoV-2 outbreak pandemic patients with SARS-CoV-2 pattern pattern recognition proteins Prevent Prophylactic Protein Recognition recognition protein reduce RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 virus severe disease severe respiratory syndrome surfactant surfactant proteins A and D (SP-A and SP-D) the SARS-CoV-2 Therapeutic approach therapy Vaccine viral particle virus worldwide pandemic Wuhan, China [DOI] 10.3389/fimmu.2021.652252 PMC 바로가기 [Article Type] Immunology
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope초강력 범-β-코로나바이러스 계통 B(β-CoV-B) 중화 항체는 보존된 에피토프를 표적으로 하여 닫힌 형태로 수용체 결합 도메인을 잠급니다Research Article Published on 2021-09-232022-09-10 Journal: Protein & Cell [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 binding ACE2 binding site administration Analysis antibody antibody-dependent cell-cell fusion antigenic binding binding antibody cell-cell fusion circulating variant circulating variants competing conserved cross-reactivity develop domain effective epitope Epitopes family member family members highlight in vivo induce Lineage neutralize neutralizes neutralizing antibody neutralizing epitope neutralizing epitopes New protective vaccine RBD Receptor-binding domain Recognition recognize reduced SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARSr-CoV WIV1 supplementary material the RBD the receptor-binding domain therapeutic therapeutic antibodies therapy threat unique Vaccine design XG005 XG014 β-coronavirus [DOI] 10.1007/s13238-021-00871-6 PMC 바로가기 [Article Type] Research Article
Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main ProteaseSARS-CoV-2 주요 프로테아제에 의한 다양한 바이러스 기질의 인식Article Published on 2021-09-102022-09-11 Journal: ACS Infectious Diseases [Category] Coronavirus, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acid substitution amino acid substitutions antiviral drug catalysis catalytic changes in cleavage cleavage site cleave conserved coronavirus coronavirus disease Coronaviruses COVID-19 crystal structure crystal structures Efficiency ENhance homologous junction lifecycle M pro MPro NSP8 parameters peptide peptides polyprotein protease Proteases provide Recognition recognize Replication residue SARS-CoV-2 severe acute respiratory syndrome Coronavirus Structure structures substrate the SARS-CoV-2 unique viral nonstructural protein viral nonstructural proteins viral replication Virology Visualization [DOI] 10.1021/acsinfecdis.1c00237 PMC 바로가기 [Article Type] Article
Primary care professionals’ experiences during the first wave of the COVID-19 pandemic in Greece: a qualitative study그리스의 Covid-19 Pandemic의 첫 번째 물결 중 1 차 진료 전문가의 경험 : 질적 연구Research Published on 2021-09-032022-09-10 Journal: BMC Family Practice [Category] SARS, 치료기술, [키워드] analysed Analysis applied Burnout Care chronic disease Community conducted consequence Contact coronavirus country COVID-19 COVID-19 pandemic crisis detect Effectiveness emotional empowerment Exhaustion First wave General practitioners Greece groups Health care Health care system health care systems Healthcare system hospital hospitals identify information information infrastructure internal internal medicine interview Isolation knowledge left behind management medical service medical services Medicine Nurses outbreak pandemic Patient Patient management patients Personal protective equipment prevention programmes primary care Primary Health Care professional Recognition recruited Region Result Symptom tested thematic analysis transcribed vaccination Viral Viral transmission [DOI] 10.1186/s12875-021-01522-9 PMC 바로가기 [Article Type] Research