The Associations of Lymphocyte Ratio and Neutrophil Ratio on Liver Dysfunction in COVID-19 PatientsCOVID-19 환자의 간 기능 장애에 대한 림프구 비율과 호중구 비율의 연관성Immunology Published on 2021-09-062022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] adjusted Admission age Analysis association AST baseline blood sample Blood samples BMI China COVID-19 COVID-19 patient COVID-19 patients Cutoff determined by group groups Hospitalized IMPROVE incidence increased risk Inflammation Kaplan–Meier liver dysfunction liver dysfunctions Liver function lymphocyte Lymphocytes magnitude management Mild moderate neutrophil Neutrophils Occurrence over Patient patients Predictive Predictive value Ratio reflect Sex significant difference significant differences subsequent tested the patient threshold [DOI] 10.3389/fimmu.2021.717461 PMC 바로가기 [Article Type] Immunology
Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2Accelerated Communication Published on 2021-08-312022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor ACE2, angiotensin-converting enzyme 2 acquisition AEC, airway epithelial cell angiotensin-converting enzyme 2 B.1.1.7 biochemical BLI, biolayer interferometry bypassed coronavirus COVID-19 COVID-19 pandemic dissect domain effect of temperature functional glycoprotein Host host receptor Hypothesis Impact increase in Interaction ITC, isothermal titration calorimetry Lineage mAb, monoclonal antibody N501Y N501Y mutation neutralization outbreak pandemic RBD RBD-ACE2 RBD, receptor-binding domain RBM, receptor-binding motif reflect respiratory viral infection responsible resulting SARS-CoV-2 spike spike glycoproteins suggested temperature tested the RBD the Spike translated transmissibility of SARS-CoV-2 Transmission variants of concern viability virus VOC, variant of concern VOCs VOI, variant of interest WT, wild-type [DOI] 10.1016/j.jbc.2021.101151 PMC 바로가기 [Article Type] Accelerated Communication
Neuroradiological emergency consultations during the first year of the COVID-19 pandemicResearch Article Published on 2021-08-302022-10-30 Journal: Neurological Research and Practice [Category] COVID-19, [키워드] Affect age and gender Analysis analyzed Care change Computed tomography conditions conducted Consultations coronavirus COVID-19 COVID-19 pandemic COVID-19 testing declined distribution Effect Germany hospital incidence Infection measure NEC NECs not significant pandemic Patient reflect remained Result risk stroke supplementary material Transient ischemic attack Transmission university hospital Weekly with COVID-19 [DOI] 10.1186/s42466-021-00147-8 PMC 바로가기 [Article Type] Research Article
The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort studyObservational Study Published on 2021-08-302022-10-04 Journal: BMC Medicine [Category] MERS, SARS, 임상, [키워드] adjusted Adjusting Admission admitted to ICU age all-cause mortality approach association baseline Bayesian Characteristics Comorbidity complex Coronavirus infection COVID-19 criteria Critical care demographic characteristics Deprivation determine diabetes disease England English Factor Factors group Hierarchical highlight hospital Hospital mortality hypertension ICU Immunosuppression In-hospital Increasing individual intensive care patient intensive care unit Liver disease mechanical ventilation mechanical ventilator mitigate Mortality mortality rate mortality risk National Neurological disease obesity Observational cohort study Patient public health surveillance quality of healthcare recorded reflect renal required Research resource Respiratory disease Result retrospective retrospective cohort study Sex study inclusion submitted supplementary material Surveillance was used [DOI] 10.1186/s12916-021-02096-0 PMC 바로가기 [Article Type] Observational Study
COVID-19 and Acute Coronary Syndromes: From Pathophysiology to Clinical PerspectivesReview Article Published on 2021-08-302022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, MERS, SARS, [키워드] addition Affect aggregation Anemia atherosclerotic plaque cardiovascular risk cellular damage clinical Clinical course condition Coronary coronary syndrome coronavirus disease COVID-19 COVID-19 patient decrease described Effect Endothelial cell Endothelial dysfunction expression generate Hyperinflammatory hypoxic induce Injury Local Logistic management Microvascular thrombosis Mortality myocardial damage Myocardial infarction oxidative stress oxygen oxygen supply Pathogenesis pathophysiology Patient Perspective Platelet platelets count potential mechanism promote Prothrombin time prothrombotic prothrombotic state reflect reported Research Sepsis severe disease Shock subject superoxide anions systemic inflammatory response therapeutic thrombus formation tissue type 1 MI von Willebrand factor with COVID-19 [DOI] 10.1155/2021/4936571 PMC 바로가기 [Article Type] Review Article
Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responsesArticle Published on 2021-08-252022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] activated Cell Cell Biology cell lines Comparative Computational biology and bioinformatics COVID-19 disease Critical disease status Diseases Endoplasmic reticulum Express expression level hACE2 HEK293T cell Host Host immune response human Angiotensin-converting enzyme immune attack immune response immune responses immunology infected cell Infection Infection route innate immune response mechanism Microbiology model system Molecular biology overexpress Pathogenesis pathway progression Protein provided reflect reveal robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell severity of COVID-19 Stress Systems biology Transcriptome transcriptomic analysis triggering Viral load virus [DOI] 10.1038/s41598-021-96462-w PMC 바로가기 [Article Type] Article
Personal Passive Air Samplers for Chlorinated Gases Generated from the Use of Consumer ProductsArticle Published on 2021-08-252022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] chamber test chlorinated chlorinated disinfectant chlorine gas Concentration conditions consumer COVID-19 Dilution Effect explained General population investigated Passive personal passive air sampler (PPAS) product reactive reflect resulting Volume was determined [DOI] 10.3390/ijerph18178940 PMC 바로가기 [Article Type] Article
Recent Insights into the Measurement of Carbon Dioxide Concentrations for Clinical Practice in Respiratory MedicineReview Published on 2021-08-212022-10-29 Journal: Sensors (Basel, Switzerland) [Category] COVID-19, [키워드] Accuracy alveolar assessment Bland–Altman analysis Blood blood gas analysis capillary blood carbon carbon dioxide change children clinical Clinical practice Concentration dioxide end-tidal end-tidal partial pressure Endotracheal intubation estimate Frequency Gas exchange gold standard insight measure measurement mechanical ventilation Medicine metabolism Non-invasive obesity oxygen performed Practice provide Quotient recent reflect Regulation respiratory sleep apnea syndrome sleep disorders These data transcutaneous partial pressure Ventilation [DOI] 10.3390/s21165636 PMC 바로가기 [Article Type] Review
Systematic evaluation of COVID-19 related Internet health rumors during the breaking out period of COVID-19 in ChinaOriginal Article Published on 2021-08-182022-10-31 Journal: Health Promotion Perspectives [Category] COVID-19, [키워드] Anxiety blind China Chinese collected Confusion coronavirus disease COVID-19 evaluated evaluator Evidence Health Health rumor Internet interquartile range IQR item Likert scale lowest median MOST outbreak Panic percentages platform public health reflect Research score scored Systematic evaluation The breaking out period of COVID-19 the median WeChat [DOI] 10.34172/hpp.2021.37 PMC 바로가기 [Article Type] Original Article
Differentially conserved amino acid positions may reflect differences in SARS-CoV-2 and SARS-CoV behaviourOriginal Papers Published on 2021-08-152022-10-28 Journal: Bioinformatics [Category] COVID-19, [키워드] ACE2 Amino acid antibody Cell culture cell tropism cellular cleavage conserved discrepancy effective genomic variation human-to-human transmission in-silico information inhibited Interaction Mortality motivation Novel coronavirus pandemic performed receptor reflect Result SARS-CoV SARS-CoV S SARS-CoV-2 SARS-COV-2 infection sensitivity susceptibility the S protein TMPRSS2 TMPRSS2 level virus virus entry [DOI] 10.1093/bioinformatics/btab094 PMC 바로가기 [Article Type] Original Papers