Waning immunity six months after BioNTech/Pfizer COVID-19 vaccination among nursing home residents in Zagreb, Croatia크로아티아 자그레브의 요양원 거주자의 BioNTech/Pfizer COVID-19 백신 접종 후 6개월 만에 면역력 약화Short Communication Published on 2021-12-012022-09-10 Journal: Croatian Medical Journal [Category] SARS, 치료기술, [키워드] All participant All participants Antibody titer booster dose contribute correlated COVID-19 COVID-19 patient COVID-19 vaccination Croatia defined dose enrolled had no highest Humoral immunity Immunity IQR Mann-Whitney Mann-Whitney U median titer men neutralization neutralization test Neutralizing antibodies neutralizing antibody Neutralizing antibody titer nursing home participant positive Research Result SARS-COV-2 infection SARS-CoV-2 strain serum dilution significantly significantly higher Spearman tested vaccination Vero E6 Vero E6 cell VERO E6 cells virus virus neutralization test was used [DOI] 10.3325/cmj.2021.62.630 PMC 바로가기 [Article Type] Short Communication
Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strainsResearch Article Published on 2021-11-302022-10-04 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody B.1.351 B.1.617.2 Breakthrough infection COVID-19 Delta description disease dose Efficacy High-dose immune responses Immunity immunized individual K18-hACE2 mice low-dose Lung infection Lung pathology magnitude Moderna mRNA vaccine mRNA vaccination mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273.351 neutralizing antibody occur Pneumonia Prevent produced PROTECT protection Protective reduced SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variants SARS-CoV-2 WA1/2020 serum serum titer Spike protein T cell responses the spike protein vaccination Vaccine Vaccines variant viral variant virus virus variants viruses weight loss Wuhan-1 [DOI] 10.1126/scitranslmed.abm3302 PMC 바로가기 [Article Type] Research Article
Persistence of SARS-CoV-2 infection on personal protective equipment (PPE)개인 보호 장비에 대한 SARS-COV-2 감염의 지속성 (PPE)Research Published on 2021-11-192022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 치료기술, [키워드] Cell Compound COVID-19 Cytopathic effect determined by evaluated Face masks genomic RNA heat heat-inactivated IMPROVE in-vitro assay Infection infectious management Mask persistence Personal protective equipment positive Post-infection PPE Result risk RNA RNA stability RT-qPCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 stability SARS-CoV-2 strain Vero cells Viral viral gene viral genes Viral load virus virus infection were infected [DOI] 10.1186/s12879-021-06861-7 PMC 바로가기 [Article Type] Research
CRISPR-Cas12a-Based Detection for the Major SARS-CoV-2 Variants of Concern우려의 주요 SARS-CoV-2 변이체에 대한 CRISPR-Cas12a 기반 탐지Research Article Published on 2021-11-172022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Amino acid amplification approach B.1.1.7 B.1.351 B.1.617.2 Beta clinical sample clinical samples Combination concern Concordance coronavirus COVID-19 pandemic CRISPR CRISPR-Cas system D614G delta variant Delta variants described detect detection Detection sensitivity E484K emerging SARS-CoV-2 variant evaluated Frame genotyping Immunity IMPROVE indicated Infection K417N L452R Laboratory Lambda limit of detection Lineage Major multiplex Mutation N501Y nucleic acid nucleic acid amplification nucleic acid amplification tests Open reading frame ORF8 PAM PCR primer protospacer adjacent motif public health Rapid test resource respiratory reverse transcription-PCR robust RT-PCR SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants Sequencing severe acute respiratory syndrome Coronavirus Spike protein T478K unmet need vaccination variant screening variants variants of concern variants of interest variants of SARS-CoV-2 virulent VOCs VOIs wild type [DOI] 10.1128/Spectrum.01017-21 PMC 바로가기 [Article Type] Research Article
In depth analysis of Cyprus-specific mutations of SARS-CoV-2 strains using computational approaches계산 접근법을 사용하여 SARS-COV-2 균주의 키프로스-특이 적 돌연변이의 깊이 분석Research Published on 2021-11-132022-09-10 Journal: BMC Genomic Data [Category] MERS, SARS, 변종, [키워드] Alter Amino acid Analysis appear association can not changes in computational approach Computational approaches conformational change Course Cyprus-specific mutations death depth analysis Frequency generate genetic data GISAID indication information lead Linear regression Linear regression model linear regression models Mutation National nucleotide nucleotide position ORF1ab gene pandemic Prevalence prevalent Protein protein structure public health Regression model regression models Result SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 strain SARS-CoV-2 strains selective sequence significantly single mutation specific mutations statistical analysis Structural prediction supplementary material the SARS-CoV-2 unique Viral viral pathogenicity Viral virulence [DOI] 10.1186/s12863-021-01007-9 PMC 바로가기 [Article Type] Research
SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strainsSARS-CoV-2 B.1.1.7(알파) 및 B.1.351(베타) 변이체는 초기 균주와 구별되는 K18-hACE2 형질전환 마우스에서 병원성 패턴을 유도합니다Article Published on 2021-11-122022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] (alpha (Beta Adaptive immunity Alpha Antibody neutralization Antimicrobial responses B.1.1.7 B.1.351 caused combating COVID-19 cytokine D-dimer death hACE2 help hypoxia Immunity immunization induce Infection intramuscular K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice lesion less medical intervention mice Mutant SARS-CoV-2 neutralization titer organ pathogenic pathology Receptor binding domain reduced Reinfection resulting SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants Signaling strain Strains Transgenic mouse Transmissibility variant variants variants of concern Viral viral infection viral spike virulence VoC VOCs [DOI] 10.1038/s41467-021-26803-w PMC 바로가기 [Article Type] Article
An outbreak of SARS-CoV-2 with high mortality in mink ( Neovison vison) on multiple Utah farms여러 유타 농장에서 밍크(Neovison vison)의 사망률이 높은 SARS-CoV-2 발생Research Article Published on 2021-11-122022-09-12 Journal: PLoS Pathogens [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Animal host animal hosts animals anorexia bat bats breadth caused Chain Reaction clinical disease collected coronavirus damage death demonstrated disease distribution early phase edema effort epithelial F486L FIVE Gross high mortality hosts Human humans In situ hybridization indicate information interstitial pneumonia Localization localized infection lower respiratory system lung Lymph node measure mink moderate molecular Mortality multiple organ multiple organs Mutation nasal turbinates necropsy Neovison Novel coronavirus occurred outbreak pathology perivasculitis polymerase chain polymerase chain reaction Polymorphisms potential transmission PPE Prevent provided pulmonary congestion Pulmonary edema RBD mutation reported reservoir reservoirs Respiratory disease respiratory tract reveal reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 viral RNA sequenced severe acute respiratory syndrome Coronavirus severe respiratory disease Spread strain susceptible symptomatic the disease The United States tissue tissues tracheobronchial Transmission unique United States upper respiratory tract Utah Vasculitis viral infection Viral RNA Viral transmission virus virus transmission while whole genome Whole genome sequencing Y453F [DOI] 10.1371/journal.ppat.1009952 PMC 바로가기 [Article Type] Research Article
Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave제 3의 COVID-19 전염병 파에서 말레이시아에서 B.1.524 (G) SARS-COV-2의 출현Article Published on 2021-11-112022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] A701V Analysis carried Cluster contributing to COVID-19 COVID-19 case COVID-19 epidemic COVID-19 pandemic descendant East emergence epidemic wave epidemic waves epidemiological link Epidemiology Genetic variation Genetic variations Genome Genome sequencing independent Lineage lineages Malaysia Mutation mutations occurred Peninsular Malaysia performed Phylogenetic Protein remained Result S-D614G mutation SARS-CoV-2 SARS-CoV-2 strain Selangor sequence sequenced specific mutation specific mutations spike Spike protein Spread spread to Strains suggested Support the SARS-CoV-2 variant virus [DOI] 10.1038/s41598-021-01223-4 PMC 바로가기 [Article Type] Article
The Predictive Value of Mutation Screening for Anticipating COVID-19 WavesCommunication Published on 2021-11-112022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] can be used Care COVID-19 COVID-19 case deaths Delta drastic Efficacy Efficiency FIVE generate genotyping gold standard growth Health help immune response increase in increases in Infection marker mathematical measure molecular Mutation Pandemics Positive predictive value PPV prediction Predictive Prevalence professional raising reduce cost SARS-CoV-2 strain Screening screening test strain Surveillance Transmissibility value variant variants Wave WGS [DOI] 10.3390/pathogens10111464 PMC 바로가기 [Article Type] Communication
Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1Immunology Published on 2021-11-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 2-deoxyglucose 2-DG binding blocked COVID-19 cytokine cytokine production dependent on Deprivation direct infection dose-dependent drug experiments Glucose Glycolysis hallmark hyperinflammation hyperinflammatory state immunometabolism implication increase in induce Inflammation Inflammatory cytokine Inflammatory response inhibit inhibited inhibition live SARS-CoV-2 metabolism metformin mitochondrial metabolism monocyte oxidative phosphorylation pro-inflammatory pro-inflammatory cytokines regulate rescued SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 strain severity spike Spike protein stimulated subunit suppresse suppressed the SARS-CoV-2 Treatment undergo upregulating viral spike protein WA1/2020 [DOI] 10.3389/fimmu.2021.733921 PMC 바로가기 [Article Type] Immunology