Associations between genetic mutations in different SARS-CoV-2 strains and negative conversion time of viral RNA among imported cases in Hangzhou: A cross-sectional studyArticle Published on 2024-05-202024-09-05 Journal: Virus Research [Category] update2024, [키워드] genetic mutation imported cases Negative conversion SARS-CoV-2 strain [DOI] 10.1016/j.virusres.2024.199400 PMC 바로가기 [Article Type] Article
Fully Automated CRISPR-LAMP Platform for SARS-CoV-2 Delta and Omicron VariantsArticle Published on 2022-11-082022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] 95% confidence interval Accuracy amplification automated B.1.617.2 Combined CRISPR D614G Delta detect Detection limit diagnostic diagnostic systems IMPROVE limit mutant mutations omicron P681H P681R platform Point mutation RdRP reaction RNA SARS-CoV-2 SARS-CoV-2 strain sensitivity Sensitivity and specificity specificity spike stability T478K variants wild type [DOI] 10.1021/acs.analchem.2c03607 PMC 바로가기
Whole-genome sequence analysis reveals the circulation of multiple SARS-CoV-2 variants of concern in Nairobi and neighboring counties, Kenya between March and July 2021Article Published on 2022-11-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] adaptive Analysis analyzed B.1.1.7 B.1.351 B.1.617.2 Beta bioinformatics circulation community transmission comparison Coronaviruses COVID-19 COVID-19 cases Delta Epidemics genome sequence increase in Kenya Lineage majority Mutation Neutralizing antibodies Oxford Nanopore Technologies Phylogenetic Prevalence protocol reduced Region regions reveal RNA RT-PCR SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variant sequence Sequence analysis Sequencing Spread Strains study period the SARS-CoV-2 variant virulence virus virus transmissibility VoC was performed [DOI] 10.1186/s12985-022-01895-y PMC 바로가기
The mutation features and geographical distributions of the surface glycoprotein (S gene) in SARS-CoV-2 strains: A comparative analysis of the early and current strainsArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] ACE2-binding region acute respiratory syndrome Analysis analyzed coronavirus coronavirus disease COVID-19 COVID-19 vaccines demonstrated develop Evolution feature Frequency Genome genome mutations geographical distribution highest identify loci mutant strain Mutation omicron prevalent remained Result S gene S protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant strain Strains Surface glycoprotein the receptor-binding domain the S protein The United States United Kingdom Vaccines was used [DOI] 10.1002/jmv.28023 PMC 바로가기
B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman PrimatesArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addition Alpha animal model association B.1.351 Beta caused changes in Characteristics Chinese circulating Clinical signs contribute determine distribution drugs early stage Efficacy and safety elevated exhibited IFN-γ IL-17 Infection Inflammatory Inflammatory cytokine interferon gamma interleukin 17 investigated less Lower respiratory tract lung tissue mechanisms mutated Necrosis NHP NHPs nonhuman primate pathogenesis of SARS-CoV-2 pathogenic pathogenicity pathological changes primate provide pulmonary inflammation reduced replicated Research rhesus macaque SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe lung injury shedding spike-specific T-cell response strain Strains tissue TNF-α Transmission upper respiratory tract Vaccine variant variants of concern viral distribution viral shedding virulence virulent VoC VOCs were infected [DOI] 10.1128/spectrum.02263-22 PMC 바로가기
Effectiveness of Monovalent mRNA Vaccines Against COVID-19-Associated Hospitalization Among Immunocompetent Adults During BA.1/BA.2 and BA.4/BA.5 Predominant Periods of SARS-CoV-2 Omicron Variant in the United States – IVY Network, 18 States, December 26, 2021-August 31, 2022Article Published on 2022-10-212022-11-16 Journal: Morbidity and Mortality Weekly Report [Category] COVID19(2023년), SARS, 변종, [키워드] accounted Against B.1.1.529 booster dose category COVID-19 vaccine dose Effectiveness eligible adult estimate expected Hospitalization Immunity immunocompetent adult immunogenic include Infection Interpretation Lineage lineages majority monovalent mRNA mRNA component mRNA COVID-19 vaccine mRNA vaccine network omicron overlapped Period predominant Prevent protection receive reduce replaced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain second dose the United State vaccination Vaccine Vaccine-induced immunity variant waned [DOI] 10.15585/mmwr.mm7142a3 PMC 바로가기
Local monitoring of SARS-CoV-2 variants in two large California counties in 2021Article Published on 2022-10-112022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Advarra Alpha variant analyzed approved carried caused changed changes in Cohort conducted confidence interval coronavirus COVID-19 Cycle threshold value Delta delta variant effort enrolled Enrollment Epidemiology genomic data Hispanic identify individual institutional review board Laboratory less Los Angele MONITOR Mutation nare nasal offered Older over participant Participants PCR polymerase chain positive Positive test Prevalence proportion public health resulting Sample SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 strain SARS-CoV-2 testing SARS-CoV-2 variant Sequencing sequencing data Spanish specimen specimens statistical study enrollment study period Surveillance swab specimen Symptom tested transported variant variants of concern women [DOI] 10.1038/s41598-022-21481-0 PMC 바로가기
Genomic diversity of SARS-CoV-2 in Pakistan during the fourth wave of pandemic전염병의 네 번째 물결 동안 파키스탄에서 SARS-CoV-2의 게놈 다양성Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] A222V acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha B.1.617.2 Beta variant characteristic circulating circulation conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D950N delta variant Delta variants exhibited followed by G142D genomic Genomic surveillance Germany globe highlight Illumina isolate isolates Karachi L452R lineages P681R Pakistan pandemic Patient Phylogenetic analysis SARS-CoV-2 SARS-CoV-2 strain severe acute respiratory syndrome Coronavirus Singapore spike mutation T19R T478K United Kingdom V483A variant variants variants of concern whole-genome sequencing [DOI] 10.1002/jmv.27957 PMC 바로가기 [Article Type] Article
Full seroconversion in initial non-responders with higher antibody levels after heterologous COVID-19 vaccination scheduleArticle Published on 2022-10-012022-11-15 Journal: Immunology letters [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] analyzed antibody Antibody testing ChAdOx1 vector vaccine circulating COVID-19 COVID-19 vaccination COVID-19 vaccine cross-reactive antibody detectable dose ENhance first dose Heterologous Heterologous COVID-19 vaccine schedule homologous humoral immune response IgG titer immune individual initial Initial non/low responder neutralization titer neutralizing antibody non-responder positive Retrospective study SARS-CoV-2 strain second dose Seroconversion Vaccination strategy vaccine dose vaccinee variants of concern [DOI] 10.1016/j.imlet.2022.09.001 PMC 바로가기
Safety, immunogenicity, and immune persistence of two inactivated COVID-19 vaccines replacement vaccination in China: An observational cohort studyArticle Published on 2022-09-162022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] administration Adverse reaction All participant anti-SARS-CoV-2 approved BBIBP-CorV can be used China Complete control group COVID-19 COVID-19 vaccine Cytopathic effect dose doses first dose geometric mean concentration geometric mean titer GMCs GMTs healthy immune persistence immunogenicity Immunoglobulin inactivated Inactivated vaccine Mild mitigate moderate NAb National not different not significantly different observation Observational cohort study Pragmatic regimens replacement Replacement vaccine Safety safety profile SARS-CoV-2 strain second dose sera severity Standard subject vaccination WHO [DOI] 10.1016/j.vaccine.2022.08.037 PMC 바로가기