Nutritional screening based on objective indices at admission predicts in-hospital mortality in patients with COVID-19입원 시 객관적인 지표를 기반으로 한 영양 검진은 COVID-19 환자의 병원 내 사망률을 예측합니다.Observational Study Published on 2021-05-252022-09-10 Journal: Nutrition Journal [Category] SARS, 변종, 임상, [키워드] Admission baseline characteristic Characteristics China clinical Clinical data collected conducted Confirmed confirmed cases controlling coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill patients death demonstrated disease severity enrolled evaluated higher risk hospital In-hospital death in-hospital mortality infected with COVID-19 Inflammatory biomarker inflammatory biomarkers Malnutrition Mortality multivariate logistic regression nutrition nutritional status observational study parameter Patient patients with COVID-19 predict prognostic Prognostic factor Prognostic factors prognostic indicator receiver operating characteristic Result retrospective risk Severe patient significant difference significant differences status therapy variant [DOI] 10.1186/s12937-021-00702-8 PMC 바로가기 [Article Type] Observational Study
Tocilizumab in the treatment of coronavirus disease 2019 pneumonia: real-world data from a case seriesCase Series Published on 2021-05-242022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] Abstract acute respiratory distress administration adverse events Case series case sery clinical Computed tomography conducted coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine release syndrome determine died disease Disseminated intravascular coagulation IL-6 IL-6 antagonist IL-6 receptor IL-6R antagonists IMPROVE improvement indicated Inflammatory response life-threatening material mild patients moderate Mortality outcome Patient patients real-world data required Retrospective study SARS-CoV-2 Severe patient shown survival syndrome TCZ the patient Tocilizumab treated Treatment Wuhan, China [DOI] 10.2217/fvl-2020-0410 PMC 바로가기 [Article Type] Case Series
Corticosteroids for hospitalized patients with mild to critically-ill COVID-19: a multicenter, retrospective, propensity score-matched studyClinical Trial Published on 2021-05-212022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval administration analyzed assigned baseline clinical clinical microbiology clinical status coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient Day diagnosed disease disease severity Efficacy enrolled evaluate Factor hazard ratio hospital hospitalized COVID-19 patient hospitalized patient IMPROVE intubation Invasive mechanical ventilation Japan Methylprednisolone Mild multicenter network Odds ratio outcome Patient primary endpoint propensity score matching radiological finding receive reduced Registered registry required retrospective Retrospective study Severe patient severity significantly lower significantly shorter Standard dose systemic corticosteroid university use of corticosteroid Ventilation Virology with COVID-19 [DOI] 10.1038/s41598-021-90246-y PMC 바로가기 [Article Type] Clinical Trial
Genomic Epidemiology of SARS-CoV-2 From Mainland China With Newly Obtained Genomes From Henan ProvinceMicrobiology Published on 2021-05-202022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] analyzed baseline Bayesian China Clinical characteristics contribute COVID-19 epidemic COVID-19 outbreak database described Evolutionary rate genetic diversity genome sequence Henan Province hospital mainland mainland China Molecular epidemiology Patient Perspective Phylogenetic phylogenetic analyses SARS-CoV-2 sequence Sequencing severe COVID-19 Severe patient Substitution TMRCA Treatment university virus genome was obtained whole genome sequence Whole-genome sequence [DOI] 10.3389/fmicb.2021.673855 PMC 바로가기 [Article Type] Microbiology
Alteration of Autonomic Nervous System Is Associated With Severity and Outcomes in Patients With COVID-19Physiology Published on 2021-05-192022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] alteration analysed autonomic Autonomic nervous system average can be used category clinical Clinical outcome clinical outcomes collected consecutive patient coronavirus disease COVID-19 COVID-19 patients D-dimer Department discharge dysfunction heart rate heart rate variability HRV Infection interval Laboratory linear correlation lymphocyte Mild N-terminal N-terminal pro-B-type natriuretic peptide nervous Non-invasive NT-proBNP objective outcome parameter Patient positive previous study pro-B-type natriuretic peptide Prognosis psychological symptom Renmin Hospital Result severe group Severe patient severity severity of COVID-19 shown significantly lower Standard deviation subset System university Variability virus was related were assessed with COVID-19 Wuhan [DOI] 10.3389/fphys.2021.630038 PMC 바로가기 [Article Type] Physiology
Circulating Type I Interferon Levels and COVID-19 Severity: A Systematic Review and Meta-Analysis순환하는 제1형 인터페론 수치와 COVID-19 심각도: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-05-122022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age antiviral response antiviral responses article association Biomarker can not caused clinical evolution clinical manifestation clinical manifestations clinical status Comparative complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical critical COVID-19 patients critical patients cytokine Cytokines database demonstrated determine disease severity elevated evaluated Evidence evidence of healthy individual healthy individuals IFN-α IFN-I IFN-α immunological alteration infections interferon interferon response interferons Level limit of detection marker means Meta-analysis Mild mild cases Mild disease no significant difference outcome outcomes Pathogenesis Patient patients performed peripheral plasma Plasma levels plasma protein random effect Reporting respiratory Result resulting review SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases Severe patient severity severity of COVID-19 Sex significant difference SMD standardized mean difference the MEDLINE Type Type I IFN type I interferon type I interferons was measured was performed Web of Science with mild disease [DOI] 10.3389/fimmu.2021.657363 PMC 바로가기 [Article Type] Meta-Analysis
Predictive values of biochemical markers as early indicators for severe COVID-19 cases in admissionResearch Article Published on 2021-05-112022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] Abstract Admission Analysis Area biochemical marker biochemical markers Biomarkers Blood urea nitrogen blood urea nitrogen/albumin ratio cause co-morbidity-age-lymphocyte-LDH score COVID-19 diagnose evaluated explain information material morbidity and mortality neutrophil/albumin ratio pandemic parameter Patient Predictive Predictive value Predictive Value of Tests prognostic Protein SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe disease Severe patient severe patients severity Severity of disease statistically the disease with COVID-19 [DOI] 10.2217/fvl-2020-0319 PMC 바로가기 [Article Type] Research Article
The influence of HLA genotype on the severity of COVID‐19 infectionOriginal Article Published on 2021-05-042022-10-31 Journal: HLA [Category] COVID-19, SARS, [키워드] age age and sex allele allele frequency analysed Antibody testing Asymptomatic Blood BMI carried classical Clinical outcome Clinical severity cohorts Comorbidities complex COVID COVID‐19 COVID‐19 infection COVID‐19 determine DRB1*04:01 European European population Evidence Frequency genetic architecture genetics Genotype greater group had no Haplotype healthy control HLA HLA gene hospital Hospital staff hypothesised immune system Inclusion individual influence latitude Local logistic regression modelling loss of smell/taste National North ordinal logistic regression Patient populations provide reported Sequencing Severe patient severe respiratory disease severity Sex significant difference significantly lower Symptom systemic symptom Treatment validation Variation virus [DOI] 10.1111/tan.14284 PMC 바로가기 [Article Type] Original Article
Composition of the immunoglobulin G glycome associates with the severity of COVID-19코로나19의 중증도와 관련된 면역글로불린 G 글리코메의 구성Article Published on 2021-05-032022-09-12 Journal: Glycobiology [Category] SARS, 진단, [키워드] acute respiratory syndrome Analysis association Biomarker Bisecting GlcNAc cohorts coronavirus coronavirus disease COVID-19 decrease develop disease disease biomarkers disease severity evaluated Factors galactosylation. glycosylation hospital IgG IgG glycosylation immune immune system Immunoglobulin implicated involved Italy mild case multiple testing notable Pandemics Portugal predict question Regulation Severe case severe disease Severe patient severity of COVID-19 Severity of disease Spain statistically significant statistically significant difference subset Symptom Variation [DOI] 10.1093/glycob/cwaa102 PMC 바로가기 [Article Type] Article
Validation of red cell distribution width as a COVID-19 severity screening toolResearch Article Published on 2021-04-202022-10-31 Journal: Future Science OA [Category] COVID-19, [키워드] Abstract Analysis Blood calculate Cell complete blood count COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity criteria death diagnosing distribution evaluated group high mortality high risk independent indicated Infection Mortality multivariate no risk predict Predictive Probability RDW-SD Red cell Red cell distribution width risk risk of death Severe patient severity specificity Standard deviation statistical analysis the WHO validation variables were used [DOI] 10.2144/fsoa-2020-0199 PMC 바로가기 [Article Type] Research Article