Serum Calcium and Vitamin D levels: Correlation with severity of COVID-19 in hospitalized patients in Royal Hospital, OmanObservational Study Published on 2021-06-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 임상, [키워드] all age group association calcium chronic respiratory diseases clinical scale cohort study Comorbidities correlation COVID-19 Diabetic Disease marker disease severity FIVE had more Hospitalization hospitalized patient Hypocalcemia ICU admission infections laboratory parameter marker Multiple Oman outcomes P-value parameter Patient primary endpoint Prognosis progression Research risk factor secondary endpoint severity of COVID-19 Severity of disease Vitamin D vitamin D level were used with COVID-19 [DOI] 10.1016/j.ijid.2021.04.050 PMC 바로가기 [Article Type] Observational Study
SARS‐CoV‐2 antibodies: IgA correlates with severity of disease in early COVID‐19 infectionResearch Article Published on 2021-05-122022-10-04 Journal: Journal of medical virology [Category] SARS, 진단, [키워드] acute respiratory syndrome Admitted Patient age age and sex analyses antibody Antibody testing association collected coronavirus coronavirus disease correlated COVID‐19 COVID‐19 infection COVID‐19 Critical Critical disease Day detectable Diagnosis disease disease severity duration of symptoms ELISA evaluate examined gold highest hospital hospitalized patient IgA IgA antibodies IgA level IgG IgG antibody IgG positivity IgM IgM antibody Immunoglobulin immunoglobulin A Infection Multiple regression observé Patient polymerase chain positive predominant remained SARS‐CoV‐2 SARS‐CoV‐2 sera serology serum sample Severity of disease Sex significant difference significantly Standard statistically Support Symptom tested [DOI] 10.1002/jmv.27058 PMC 바로가기 [Article Type] Research Article
Predictive values of biochemical markers as early indicators for severe COVID-19 cases in admissionResearch Article Published on 2021-05-112022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] Abstract Admission Analysis Area biochemical marker biochemical markers Biomarkers Blood urea nitrogen blood urea nitrogen/albumin ratio cause co-morbidity-age-lymphocyte-LDH score COVID-19 diagnose evaluated explain information material morbidity and mortality neutrophil/albumin ratio pandemic parameter Patient Predictive Predictive value Predictive Value of Tests prognostic Protein SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe disease Severe patient severe patients severity Severity of disease statistically the disease with COVID-19 [DOI] 10.2217/fvl-2020-0319 PMC 바로가기 [Article Type] Research Article
Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?Immunology Published on 2021-05-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] adeno-associated virus antibody antigens Can Clinical efficacy Clinical studies Conventional de novo synthesis Diseases Efficacy Efficiency expression Fighting foreign protein game Gene therapy genomic variation HIV Host Immunity immunomodulatory immunotherapies Immunotherapy in vivo Infection Infectious disease Influenza inherent lentivirus malaria mechanism neutralizing antibody offer passive transfer Pathogens pre-existing immunity profiles Prophylactic reduce repeated Severity of disease single dose tested therapeutic strategy Topology transgene Treatment vaccination Vaccines vectors viral vectors virus [DOI] 10.3389/fimmu.2021.673699 PMC 바로가기 [Article Type] Immunology
Prognostic Factors in Hospitalized COVID-19 Patients at the Start of the Pandemic in Colombia: A Retrospective Cohort StudyInternal Medicine Published on 2021-05-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] age Analysis Comorbidities covid prognosis COVID-19 COVID-19 mortality Critical defined determine died disease mortality evaluate explain Factor greater Hospital admission hospitalized COVID-19 patient hospitalized patient hyperinflammation Hyperinflammatory syndrome in-hospital mortality independent information Latin LDH material Mortality multivariate logistic regression NEWS2 objective Older age PaO2/FiO2 ratio Patient patients performed populations Prognostic factor required Result retrospective cohort study SARS CoV-2 score serum Seven severe disease severity Severity of disease Tocilizumab type 2 diabete was performed [DOI] 10.7759/cureus.14865 PMC 바로가기 [Article Type] Internal Medicine
Randomised, double-blind, placebo-controlled trial of Probiotics To Eliminate COVID-19 Transmission in Exposed Household Contacts (PROTECT-EHC): a clinical trial protocol노출된 가구 접촉에서 COVID-19 전파를 제거하기 위한 프로바이오틱스의 무작위, 이중 맹검, 위약 대조 시험(PROTECT-EHC): 임상 시험 프로토콜Article Published on 2021-05-052022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 16S rRNA Affect Analysis approval behavioural changes in clinical trial clinical trials collected conducted Contact COVID-19 COVID-19 infection COVID-19 infection status COVID-19 pandemic disseminate double-blind double-blinded drug Drug administration Duke enrolment Ethics evaluate evaluate the effect Evidence food gastroenterology Gut gut microbiome Health household hypothesise Infection infections Infectious diseases institutional review board International Lactobacillus rhamnosus microbial Microbiology Microbiome mitigate Modification Multivariate analysis nasal swab nasal swabs National New Other outcomes other variable outcomes PCR peer-reviewed Placebo placebo-controlled trial positive predict Probiotic Probiotics PROTECT protocol public health randomised reduce registration number Respiratory tract infections rRNA SARS-CoV-2 Sequencing severity of COVID-19 Severity of disease Spread Stool sample stool samples subject susceptibility Symptom Symptoms tested Trial university [DOI] 10.1136/bmjopen-2020-047069 PMC 바로가기 [Article Type] Article
Epidemiological and clinical characteristics of imported cases of COVID-19: a multicenter studyResearch Article Published on 2021-05-032022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, [키워드] age Asymptomatic disease Beijing calculated Characteristics China Chongqing Clinical characteristics clinical feature Clinical feature; imported case Clustering conducted Contact coronavirus disease cough COVID-19 COVID-19 severity declined discharge Dyspnea early stage enrolled epidemiological Epidemiological characteristics expand Fatality rate fatigue Fever Frequency generate headache help hospital imported case Infection Local male medical service Mild MOST multicenter new infection Occurrence pandemic Patient patients with COVID-19 Prevent Primary outcome Result SARS-COV-2 infection Severity of disease Sex significantly Spread Symptom transferred were used Wuhan [DOI] 10.1186/s12879-021-06096-6 PMC 바로가기 [Article Type] Research Article
Composition of the immunoglobulin G glycome associates with the severity of COVID-19코로나19의 중증도와 관련된 면역글로불린 G 글리코메의 구성Article Published on 2021-05-032022-09-12 Journal: Glycobiology [Category] SARS, 진단, [키워드] acute respiratory syndrome Analysis association Biomarker Bisecting GlcNAc cohorts coronavirus coronavirus disease COVID-19 decrease develop disease disease biomarkers disease severity evaluated Factors galactosylation. glycosylation hospital IgG IgG glycosylation immune immune system Immunoglobulin implicated involved Italy mild case multiple testing notable Pandemics Portugal predict question Regulation Severe case severe disease Severe patient severity of COVID-19 Severity of disease Spain statistically significant statistically significant difference subset Symptom Variation [DOI] 10.1093/glycob/cwaa102 PMC 바로가기 [Article Type] Article
Clinical course of COVID-19 disease in immunosuppressed renal transplant patientsArticle Published on 2021-04-302022-10-29 Journal: Turkish Journal of Medical Sciences [Category] COVID-19, MERS, SARS, [키워드] acute rejection Admission age biochemical parameter clinical clinical setting complications Course COVID-19 COVID-19 disease Dexamethasone died discharge discharged dosage duration of hospitalization effective Follow-up high risk hospital Hospitalization identify Immunosuppressed Immunosuppression immunosuppressive information inhibitor Inpatient Kidney injury kidney transplant Kidney transplantation Laboratory male material Methylprednisolone Mortality no significant difference Patient patients patients with COVID-19 reduced reducing reduction rehospitalization rejection renal Result Retrospective study Safe SARS-CoV-2 Severity of disease Treatment were recorded withdrawn [DOI] 10.3906/sag-2007-260 PMC 바로가기 [Article Type] Article
Towards computer-aided severity assessment via deep neural networks for geographic and opacity extent scoring of SARS-CoV-2 chest X-raysArticle Published on 2021-04-292022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] acute respiratory syndrome Care Chest chest X-ray Clinical use coronavirus coronavirus disease COVID-19 Critical CXR deep learning Diagnosis effective evaluated experiments feasibility Geographic Lung disease lung involvement Metrics pandemic Patient positive predicted progression radiologist random SARS-CoV-2 scored severity Severity of disease stratified subset Treatment viral infection [DOI] 10.1038/s41598-021-88538-4 PMC 바로가기 [Article Type] Article