The Biobanque québécoise de la COVID-19 (BQC19)—A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectoriesBiobanque québécoise de la COVID-19(BQC19) - COVID-19 임상 궤적의 임상 및 생물학적 결정 요인을 전향적으로 연구하기 위한 코호트Research Article Published on 2021-05-192022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] addition analyses anti-SARS-CoV-2 antibody approved Canada circulating Clinical data clinical variables Cohort Community coordination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 crisis death determinant disease DNA and RNA effort global pandemic health authorities Health Organization Hospitalized immediate action include individuals Infection International limit Local magnitude management Manifestations marker metabolome mononuclear cell multiplex National Novel coronavirus novel coronavirus disease organized outbreak pandemic patients Peripheral blood Peripheral blood mononuclear cells plasma positive proteome Research researcher responses responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR serum Spectrum storage trajectory Transcriptome transcriptome sequencing uninfected urgency Whole blood whole genome World Health Organization [DOI] 10.1371/journal.pone.0245031 PMC 바로가기 [Article Type] Research Article
Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial StrainsArticle Published on 2021-05-172022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] Acinetobacter activity addition antibacterial activity Antibiotics antimicrobial antimicrobial peptide antimicrobial peptides Bacteria Candida albican Cell toxicity chemical derivatives Cm-p5 Compound Concentration Corona demonstrated derivative dose-dependent manner Enterococcus faecium ESBL eukaryotic cell evaluated Extended Extracellular had no Herpe Infection inhibited Klebsiella pneumoniae microbial moderate monomer multiresistant microorganisms Mycobacterium tuberculosis pathogenic strain peptide Pseudomonas aeruginosa pseudoparticle respiratory SARS-CoV-2 Spectrum strain Streptococcus tested Toxicity virulent Zika ZIKV [DOI] 10.3390/biom11050745 PMC 바로가기 [Article Type] Article
Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seqLIBRA-seq를 통한 회복기 COVID-19 환자의 SARS-CoV-2 특이적 기억 B 세포의 신속한 분리 및 면역 프로파일링Article Published on 2021-05-172022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단, [키워드] activated Adaptive immunity analyzed antibody Antigen B cell response BCR binding affinity CD11c Cell convalescent COVID-19 patient convalescent COVID-19 patients convalescent individuals Critical Diversity domain ELISA assay exhibited FIVE Frequency heterogeneity immune profiling immune responses Immunoglobulin in vitro Infectious diseases Isolation memory memory B memory B cell memory B cells Neutralizing activity nucleoprotein performed plasma B cell plasma B cells proportion provide pseudotyped Rapid RBD SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 virus Sequencing single-cell level Single-cell RNA sequencing specificity Spectrum transcriptional VDJ Via [DOI] 10.1038/s41392-021-00610-7 PMC 바로가기 [Article Type] Article
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates중화 항체 LY-CoV555는 비인간 영장류에서 SARS-CoV-2 감염을 예방합니다Research Article Published on 2021-05-122022-09-12 Journal: Science Translational Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway airways angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-spike antibody Antigen antigen-specific B cell Antigen-specific B cells B cells bamlanivimab binding characterized clearance clinical testing Clinical use collected conducted convalescent patient coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated evaluated functional high-affinity binding Hospitalized in vitro in vivo indications individual infected with SARS-CoV-2 Infection Interaction Jone Jones less Lower respiratory tract LY-CoV555 mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody offer patients with COVID-19 pharmacokinetic Population prevented prophylactic dose prophylactic doses prophylactic treatment PROTECT public health threat Receptor-binding domain reduced respiratory distress Respiratory distress syndrome rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spectrum Spike protein Support syndrome tested the receptor-binding domain therapeutic therapeutic agent therapeutic option Therapeutics These data Treatment upper and lower respiratory tract upper and lower respiratory tracts vaccination viral replication widespread [DOI] 10.1126/scitranslmed.abf1906 PMC 바로가기 [Article Type] Research Article
Dynamic and features of SARS-CoV-2 infection in Gabon가봉 SARS-CoV-2 감염의 역학 및 특징Article Published on 2021-05-062022-09-01 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단, [키워드] accounted African age age distribution Ageusia Analysis analyzed Anosmia anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antibody Response Asthma Asymptomatic asymptomatic patient asymptomatic patients Blood Blood cells blood type Blood types calculated children chronic disease Chronic diseases clinical feature Clinical features Cohort community transmission Contact COVID-19 COVID-19 patient COVID-19 severity Critical Critical disease Critical illness cured death described diabetes diagnosed Diagnosis Disease prevention distribution driving dynamic Dyspnea Epidemiology feature female Gabon Gender hypertension Infection infection rate Influenza influenza-like symptom Influenza-like symptoms information leukocytes Leukocytosis leukopenia lowest lymphocyte Lymphocyte count lymphocytopenia male median Mild-to-moderate mild-to-moderate disease neutrophil neutrophilia neutrophilic leukocytosis Neutrophils Outcomes research participant Patient positive positive patient proportion provided public health rate of infection recorded representing Respiratory failure RT-PCR SARS-CoV-2 SARS-CoV-2 infected subject SARS-CoV-2 infected subjects SARS-COV-2 infection SARS-CoV-2 RT-PCR screened Spectrum subclinical infection Treatment protocol White blood cell White blood cells [DOI] 10.1038/s41598-021-87043-y PMC 바로가기 [Article Type] Article
The Spectrum of COVID-19-Associated Myocarditis: A Patient-Tailored Multidisciplinary ApproachArticle Published on 2021-05-042022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute COVID-19 age Analysis approach Arrhythmias cardiac magnetic resonance clinical manifestation consecutive patient COVID-19 COVID-19 infection COVID-19 patients de novo diagnosed Diagnosis died disease driven by Ejection fraction Endomyocardial biopsy enrolled etiologies Follow-up Immunosuppression Infection Inflammation lack LVEF males management median Multidisciplinary myocarditis outcome Patient patients PCR polymerase chain reaction SARS-CoV-2 SARS-CoV-2 genome screened Spectrum Support therapy Treatment treatment strategy ventricular ventricular arrhythmias virus were assessed [DOI] 10.3390/jcm10091974 PMC 바로가기 [Article Type] Article
Biological responses to COVID-19: Insights from physiological and blood biomarker profilesCOVID-19에 대한 생물학적 반응: 생리학적 및 혈액 바이오마커 프로필에서 얻은 통찰력Article Published on 2021-05-012022-08-31 Journal: Current research in translational medicine [Category] MERS, SARS, 바이오마커, [키워드] accompanied Admission adverse outcomes Analysis baseline best Biological biological response biological responses Biomarker Biomarkers Blood C-reactive protein Characteristics class Classes collected Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 Course COVID-19 CRP death declined elevated empirical evidence Evidence except for exhibited FIVE heterogeneous highest hospitalised Hyperinflammatory Hyperinflammatory response Implications Inflammation Inflammatory Inflammatory response insight intensive care kidney Kidney injury laboratory-confirmed Laboratory-confirmed COVID-19 Latent latent profile analysis lowest male measure median age mortality rate mortality risk neutrophil neutrophil counts older patients pathophysiology Patient performed physiological Platelet Platelet count profile provide provided renal renal failure response retrospective cohort study rising SARS-CoV-2 severe COVID-19 Spectrum targeted therapy therapeutic understanding unique was performed white cell [DOI] 10.1016/j.retram.2021.103276 PMC 바로가기 [Article Type] Article
SARS-CoV-2-associated multisystem inflammatory syndrome in children: clinical manifestations and the role of infliximab treatment소아에서 SARS-CoV-2 관련 다기관 염증 증후군: 임상 증상 및 인플릭시맙 치료의 역할Article Published on 2021-05-012022-09-12 Journal: European journal of pediatrics [Category] 진단, [키워드] Care characterized children children with MIS-C clinical manifestation conducted Corticosteroids COVID-19 Critical care critically ill patients Detroit Diagnosis feature Fever Follow-up gastrointestinal symptoms Hypotension Immunoglobulin Immunomodulatory agents include Inflammation Inflammatory inflammatory process infliximab IVIG Kawasaki disease less management manifestation Manifestations median medical record Mild MIS-C Myocardial Myocardial dysfunction occurred Older outcome overlap Pain Patient required resolved severe inflammation Shock Spectrum syndrome therapy Treatment [DOI] 10.1007/s00431-021-03935-1 PMC 바로가기 [Article Type] Article
Parkinson’s Disease and Post–COVID ‐19 Syndrome: The Parkinson’s Long‐COVID SpectrumLetters: New Observation Published on 2021-04-282022-10-30 Journal: Movement disorders : official journal of the Movement Disorder Society [Category] COVID-19, MERS, SARS, [키워드] COVID‐19 Long COVID Parkinson's Disease Post–COVID‐19 syndrome SARS‐CoV‐2 Spectrum [DOI] 10.1002/mds.28622 PMC 바로가기 [Article Type] Letters: New Observation
Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art ReviewCOVID-19 환자를 위한 항혈전 요법의 최근 무작위 시험: JACC State-of-the-Art ReviewReview Published on 2021-04-202022-09-11 Journal: Journal of the American College of Cardiology [Category] 임상, [키워드] Anticoagulant antiplatelet Antithrombotic clinical trial coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Critically ill doses endothelial injury hospitalized patient hospitalized patients Illness severity Injury knowledge outpatients pathophysiological feature Patient Perspective provide Randomized controlled trial RCT RCTs recent regimen review Spectrum therapy thrombosis variety with COVID-19 [DOI] 10.1016/j.jacc.2021.02.035 PMC 바로가기 [Article Type] Review