Structural analysis – Page 10 – Communicable Diseases Research

Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Reveals Mosaic Pattern of Phylogeographical Distribution

Research Article

Published on 2020-07-282022-10-29
Journal: mSystems [Category] COVID-19,

[키워드] acute respiratory syndrome addition Affect age factor Amino acid Analysis analyzed binding caused circulating claimed Comparative Complete coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patients COVID-2019 evade Frame GenBank accession Genome genomic geographical region global pandemic Health health condition Host Human human receptors IL-8 impacted IMPROVE Infection interact Interaction interferon involved less methyltransferase mosaic mRNA mutant mutant proteins NKRF nonsynonymous mutation novel SARS-CoV-2 virus nsp13 nsp14 Nsp15 ORF1b outbreak pattern Pneumonia polyproteins Population Protein Replication replicative required residue RNA S-protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain severity signaling pathway Single nucleotide polymorphism SNPs Spread stability Structural analysis the disease the interferon the United State The United States Transmission transmission rates Travel unique viral isolate Viral protein viral replication viral variant virus viruses wild-type Wuhan, China
[DOI] 10.1128/mSystems.00505-20 PMC 바로가기 [Article Type] Research Article

Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2

Research Article

Published on 2020-06-292022-10-29
Journal: Journal of Medical Microbiology [Category] COVID-19, MERS, SARS,

[키워드] anti-SARS-CoV-2 antibiotic antiviral drug approved binding site broadly neutralizing antivirals Candidates Clinical use Community conformation conserved coronavirus Coronavirus replication COVID-19 COVID-19 pandemic COVID-19 therapeutics Critical cross determine docking drug drugs targeting effective enzyme Evidence expected food generate human-to-human transmission identify in silico inhibitor Initially less MERS-CoV Molecular dynamics simulation multiple coronaviruses outbreak performed Potential predicted protein evolution Quinupristin RNA RNA-dependent RNA polymerase SARS-CoV SARS-CoV-2 sequence Sequence analysis Side effects Structural analysis target therapeutic Treatment viral replication viral RNA synthesis were used
[DOI] 10.1099/jmm.0.001203 PMC 바로가기 [Article Type] Research Article

Adaption and parallel evolution of human-isolated H5 avian influenza viruses

Article

Published on 2020-06-012023-06-22
Journal: The Journal of Infection [Category] 조류인플루엔자,

[키워드] adaptive evolution H5 avian influenza virus Structural analysis
[DOI] 10.1016/j.jinf.2020.01.012

Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis of SARS-CoV-2-Related Viruses

Research Article

Published on 2020-05-292022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome Alpha Analysis arising attenuate beta-coronavirus beta-CoV Combination comparable Complete coronavirus coronavirus disease CoV COVID-19 COVID-19 pandemic determinant domain Evolution evolutionary arms race Factor Genome Genomic analysis genomic region Health Host Host immune response host immunity hosts identify immune immune evasion immune pressure Immunoglobulin individual insight macro modulate MOST novel Novel coronavirus ORF1a ORF8 outbreak Pathogenesis pathogenicity predicted Protein Proteins Receptor binding domain Region SARS SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-like coronavirus scrutiny sequence severity Structural analysis the Spike Transmission unique virus Virus-host interactions viruses widespread
[DOI] 10.1128/mBio.00760-20 PMC 바로가기 [Article Type] Research Article

Prediction and analysis of key protein structures of 2019-nCoV

Short Communication

Published on 2020-05-122022-10-31
Journal: Future Virology [Category] COVID-19,

Identification of a Novel Linear B-Cell Epitope on the Nucleocapsid Protein of Porcine Deltacoronavirus

Article

Published on 2020-01-192022-10-29
Journal: International Journal of Molecular Sciences [Category] Coronavirus,

East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide

동아시아 헬리코박터 파일로리 균주는 헵탄 결핍 지방 다당류를 합성합니다

Research Article

Published on 2019-11-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Structural insights into the Middle East respiratory syndrome coronavirus 4a protein and its dsRNA binding mechanism

Article

Published on 2017-09-122022-10-29
Journal: Scientific Reports [Category] Coronavirus, MERS,

Comprehensive structural analysis of designed incomplete polypeptide chains of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus

Research Article

Published on 2017-07-272022-10-28
Journal: PLoS ONE [Category] Coronavirus,

Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex

Research Article

Published on 2011-10-132022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] Analysis antiviral drug assays Author biochemical canonical catalytic catalyzed cellular cofactor complex composed coronavirus demonstrated different Donor drug target drugs ENCODE eukaryotic eukaryotic virus found function Immune escape in viral indicated innate immune insight inter-molecular Interaction methylated methyltransferase modify mRNA mRNA stability mRNAs non-structural protein nsp14 promote protein translation required ribose ribosome RNA RNA stability RNAs S-adenosyl-L-methionine SAM SARS Coronavirus SARS-CoV shown stimulatory Structural analysis subunit subunits unique Viral RNA virus
[DOI] 10.1371/journal.ppat.1002294 PMC 바로가기 [Article Type] Research Article