Identification of Potential Inhibitors of 3CL Protease of SARS-CoV-2 From ZINC Database by Molecular Docking-Based Virtual ScreeningMolecular Biosciences Published on 2020-12-172022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] 3CL 3CL Protease 3CLpro acute respiratory syndrome Antiviral approach AutoDock binding binding pocket catalytic dyad caused co-crystallized Compound compounds coronavirus COVID-19 docking drug target effective exhibited FDA-approved drugs FIVE functional high affinity identification inhibitor inhibitors Interaction Ligand molecular molecular docking molecular interaction outbreak Potential protease reported residue responsible SARS-CoV-2 Screening target protein the SARS-CoV-2 Vaccine viral replication Virtual screening virus Wuhan, China ZINC database [DOI] 10.3389/fmolb.2020.603037 PMC 바로가기 [Article Type] Molecular Biosciences
Raltegravir, Indinavir, Tipranavir, Dolutegravir, and Etravirine against main protease and RNA-dependent RNA polymerase of SARS-CoV-2: A molecular docking and drug repurposing approachSARS-CoV-2의 주요 프로테아제 및 RNA 의존성 RNA 중합효소에 대한 랄테그라비르, 인디나비르, 티프라나비르, 돌루테그라비르 및 에트라비린: 분자 도킹 및 약물 용도 변경 접근법Article Published on 2020-12-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 신약개발, 치료제, [키워드] 3D structure 3D Structures antiviral drug antiviral drugs approach approved AutoDock binding energy Bioavailability cause COVID-19 COVID-19 treatment daclatasvir docked docking dolutegravir drug Drug repurposing drug-likeness Elbasvir Etravirine evaluated exhibited FDA glecaprevir Grazoprevir Health help highest Indinavir Interaction lead ledipasvir main protease molecular docking morbidity morbidity and mortality MPro pibrentasvir protease Protein target protein targets PubChem raltegravir RdRP retrieved RNA RNA-dependent RNA polymerase SARS-CoV-2 screened server small molecule target protein tipranavir Treatment treatment of COVID-19 velpatasvir Viral protein Viral proteins Virtual screening was performed [DOI] 10.1016/j.jiph.2020.10.015 PMC 바로가기 [Article Type] Article
Decoding information on COVID–19: Ontological approach towards design possible therapeuticsReview article Published on 2020-11-272022-10-05 Journal: Informatics in Medicine Unlocked [Category] 신약개발, 치료제, [키워드] “cytokine storm” accelerate Antiviral approach caused Characteristics Comorbidities country COVID-19 curative Decoding drug Drug repurposing effective effective vaccine Factor globe Host host-pathogen interaction identification immune response information Intervention less medical intervention Mortality mortality rate mutant virus ontological Ontology pathogen Prevalence researcher respiratory SARS CoV-2 significantly spread to target protein targets the disease therapy unique Vaccine variations virus [DOI] 10.1016/j.imu.2020.100486 [Article Type] Review article
In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2Research article Published on 2020-11-012022-10-05 Journal: European journal of pharmacology [Category] SARS, 신약개발, [키워드] ACE2 addition angiotensin-converting enzyme 2 anti-inflammatory action antiviral drug approach approved drug bind binding binding energy can be used clinically COVID 19 COVID-19 docking drug Drug repurposing ENhance eriodictyol fatality globe HCQ Helicase Host Infection Interaction isoniazid Lopinavir molecular docking molecular docking analysis molecular interaction mycophenolic acid NSP pandemic Pemirolast Protein receptor Receptor binding domain researcher responsible SARS protein SARS-CoV-2 SARS-CoV-2 protein selected small molecule spike Spread supported target protein tested therapeutic treat Treatment understanding viral propagation virus was done [DOI] 10.1016/j.ejphar.2020.173430 [Article Type] Research article
Evaluation of SARS-CoV-2 IgG antibody response in PCR positive patients: Comparison of nine tests in relation to clinical dataPCR 양성 환자에서 SARS-CoV-2 IgG 항체 반응 평가: 임상 데이터에 대한 9가지 검사 비교Research Article Published on 2020-10-272022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] Abbott addressed antibody Antibody test Antibody testing antibody tests asymptomatic patients biosensor Clinical data Clinical practice clinical symptom Clinical symptoms controls correlated correlation COVID-19 patient DiaSorin different time points early stage epidemiological studies epitope Euroimmun explain group highlight house LIPS nine patient groups PCR positive Previous studies previous study ranged Roche S-RBD SARS-CoV-2 antibody test SARS-CoV-2 antibody testing SARS-CoV-2 antibody tests SARS-CoV-2 IgG antibody sensitivity Sensitivity and specificity serum sample serum samples Seven SNIBE specificity symptom onset target protein Variation Viral Viral antigen was performed [DOI] 10.1371/journal.pone.0237548 PMC 바로가기 [Article Type] Research Article
Potential therapeutic target identification in the novel 2019 coronavirus: insight from homology modeling and blind docking studyResearch Published on 2020-10-022022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] 2019-nCoV 3CLpro 3D structure activities administration Amino acid binding site blind carried co-crystallized coding sequence Comparative coronavirus coronavirus epidemic Coronaviruses docked docking study elicited Genome HIV protease inhibitor homology Human inhibitors International Ligand mapped Novel coronavirus outbreak polyprotein polyproteins positive-sense single-stranded RNA Potential protease Protein proteinase Proteolytic processing public health reduced Replication Result selected sequence shown target protein The 2019-nCoV therapeutic agent therapeutic target translated Treatment viral infection viral replication virus [DOI] 10.1186/s43042-020-00081-5 PMC 바로가기 [Article Type] Research
Targeting SARS-CoV-2 RNA-dependent RNA polymerase: An in silico drug repurposing for COVID-19Research Article Published on 2020-09-232022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Antibiotics approved ARG555 binding caused clinical study coronavirus disease Coronavirus-2 Coronaviruses COVID-19 determine docked docking drug Drug discovery Drug repurposing Ebola enzyme Epidemics examined FDA groups H1N1 homology in silico M pro management MERS MERS-CoV molecular Molecular dynamics simulation NSAIDS pandemic pitavastatin protease RdRP Research RNA RNA-dependent RNA polymerase SARS-CoV SARS-CoV-2 Spread Standard target protein targeting Treatment Vaccine [DOI] 10.12688/f1000research.26359.1 PMC 바로가기 [Article Type] Research Article
Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assayMethodology Published on 2020-09-102022-10-29 Journal: Journal of Nanobiotechnology [Category] Coronavirus, SARS, [키워드] accelerate analyzed antibody assays Biomarker C-reactive protein C-reactive protein (CRP caused clinically complex Conjugation chemistry consequence Conventional COVID-19 CRP Cytokine storm Diagnosis diagnostics Duplex lateral flow assay event events FIVE Gold nanoparticle handling IL-6 Image processing ImageJ immunoassay include Infection Inflammation Inflammatory information intensities interleukin-6 lateral flow limits medical need Multiplexing Nanoparticles optical pathophysiology POC point-of-care point-of-care diagnostics powerful tool provide quantification Quantitative quantum dots R-package Sandwich immunoassay Sensitivity and specificity Sepsis Shiny app target protein targets test line Treatment was used were used [DOI] 10.1186/s12951-020-00688-1 PMC 바로가기 [Article Type] Methodology
Tumor markers as an entry for SARS-CoV-2 infection?SARS-CoV-2 감염에 대한 항목으로서의 종양 표지자?Review Published on 2020-09-012022-08-31 Journal: The Febs Journal [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Basigin binding Cancer Cancer patients caused CD147 Clinical finding Clinical findings contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients death drugs Emmprin entry receptor globe Health crisis higher risk identifying Invasion marker Multiple organ damage open organ damage our times Patient Prevent Protein public health crisis receptor respiratory SARS-CoV-2 SARS-COV-2 infection severe disease Spike protein Spread target protein Treatment Tumor tumor markers Viral viral spike virus while [DOI] 10.1111/febs.15499 PMC 바로가기 [Article Type] Review
Research progress on repositioning drugs and specific therapeutic drugs for SARS-CoV-2Review Published on 2020-07-082022-10-31 Journal: Future Medicinal Chemistry [Category] COVID-19, SARS, [키워드] anti-SARS-CoV-2 antiviral drug Chloroquine clinical trials clinically COVID-19 drug drug design drugs effective global pandemic Host Limited MPro organization potential therapeutic target promoted RdRP Remdesivir reported repositioning antiviral drugs Research SARS-CoV-2 specific antiviral drugs Spread Structure target protein target proteins therapeutic drug [DOI] 10.4155/fmc-2020-0158 PMC 바로가기 [Article Type] Review