Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network비평형 억제인자 결합 동역학은 SOS 유전자 네트워크 내에서 DNA 손상 용량을 전사 타이밍에 연결합니다Research Article Published on 2018-06-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activity bacterial DNA best binding binding interaction binding kinetics Biochemical pathways cause Cell cellular Concentration Critical defined Degradation disequilibrium DNA binding DNA damage DNA damage repair pathway DNA damaging dose drop Escherichia coli expression Gene Expression Genes kinetic leads LexA low dose mechanism modulate network operator operators pathway Physiology promoter promoters rapid equilibrium assumptions regulate regulated Regulatory respond resulting reveal separated SOS gene SOS pathway SOS response subset the cell the timing These data Transcription transcription factor transcription regulation transcriptional transcriptional repressor Trigger triggers [DOI] 10.1371/journal.pgen.1007405 PMC 바로가기 [Article Type] Research Article
Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose마이코박테리아의 세포 외피 스트레스는 트레할로스에 대한 반응으로 새로운 신호 전달 ATPase IniR에 의해 조절됩니다Research Article Published on 2017-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activator Affect assembly ATPase Author BAC bacterial cell biogenesis cascade Cell cell envelope cell wall complex compounds damaged defect domain domains drug ethambutol experiment explain exposure to family Gram-negative bacteria homologue identify include induce inducer integrity involved isoniazid latter gene Lipid lipids locus mechanism Mutagenesis mutant mutants mutations mycobacteria mycobacterial Mycobacterium operon overexpression pathway promoter PROTECT regulated Regulation regulator Regulatory regulatory gene respond RNAseq shown signal Signal transduction Signaling Stress stress response sugar sugars the cell transcriptional regulator transposon trehalose Tuberculosis understanding unique [DOI] 10.1371/journal.pgen.1007131 PMC 바로가기 [Article Type] Research Article
The immune response to secondary necrotic cells이차 괴사 세포에 대한 면역 반응Review Published on 2017-08-312022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] Apoptosis apoptotic cell apoptotic cells Autoimmunity Cancer Cancer immunotherapy Cell cell surface cytoplasm DAMPs disease Effect Efferocytosis human physiology immune response immunostimulatory implication Inflammation leakage membrane integrity Modification molecular pattern molecular patterns molecules necroptosis Necrosis necrotic necrotic cell necrotic cells neurodegenerative disorder neurodegenerative disorders Primary necrosis recent regulated released Research Secondary necrosis Secondary necrotic cells the cell [DOI] 10.1007/s10495-017-1413-z PMC 바로가기 [Article Type] Review
Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarateα-케토글루타레이트의 항상성 조절을 통한 Caulobacter crescentus의 트리카르복실산 회로와 펩티도글리칸 합성 간의 누화Research Article Published on 2017-08-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation addition Alter Antibiotics approach approaches Bacteria bacterial cell bacterial cells biosynthetic block blocks building by-product Caulobacter crescentus caused Cell cell wall cell wall synthesis cellular cellular metabolism cellular processe cellular processes central metabolism characterized classical conserved CRISPRi Crosstalk deletion mutant Disruption drug design energy generate genetics growth highlight homeostasis homeostatic inhibit interfere Interference master regulator metabolism metabolite metabolomics Morphological morphology mutant peptidoglycan phenotype precursors property Replication required resulting reveal robust susceptibility susceptible synthesis TCA cycle the cell transcriptomics tricarboxylic acid while [DOI] 10.1371/journal.pgen.1006978 PMC 바로가기 [Article Type] Research Article
The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli메실리남 저항체는 대장균에서 세포벽 합성을 자극하는 펩티도글리칸 엔도펩티다제의 역할을 밝힙니다Research Article Published on 2017-07-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activating Activation addition allele Analysis Antibiotics approach Bacterial bacterial cell bacterial cells Beta Beta-lactam beta-lactam antibiotics beta-lactam mecillinam biogenesis build Cell cell wall cell wall synthesis cells characterization cleave cleaving complexes comprehensive resource contrary crosslink crosslinking crosslinks dataset downstream analysis drug drug resistance E . coli effective enzyme Enzymes Escherichia coli expand generate Genetic genetic background genetic loci Genome identify implicated induction inhibit involved killing loci locus mechanism mecillinam modulating mutant mutants organism overproduction PBP2 PBPs penicillin penicillin-binding protein penicillin-binding proteins performed PG synthase PG synthesis probe promote Reasoning required resource response reveal Stress stress response subset Synthase target the cell Tn-seq Tn-Seq analysis transpeptidase utility wild-type cells [DOI] 10.1371/journal.pgen.1006934 PMC 바로가기 [Article Type] Research Article
The nucleoid occlusion factor Noc controls DNA replication initiation in Staphylococcus aureusnucleoid occlusion factor Noc는 황색 포도구균에서 DNA 복제 개시를 조절합니다Research Article Published on 2017-07-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] assembly Author Bacillus subtilis Bacteria binding site biological processe block Cell cell division chromosome chromosome segregation chromosomes connection Control cytokinetic ring division DNA replication DNA sequence DNA sequences dnaA Economy ENhance event Factors help inactivation inhibit initiated mechanism mutant mutants Mutation organism over-expression pathogen phenotype problem Protein reduced Replication S . aureus screened segregation shown Staphylococcus aureus suppress the cell thought underlie unique Volume [DOI] 10.1371/journal.pgen.1006908 PMC 바로가기 [Article Type] Research Article
Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1단백질 키나제 Cak1의 발현 감소를 통한 칸디다 알비칸스 필라멘트/생물막 조절기 우회Research Article Published on 2016-12-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activating Activation antimicrobial Antimicrobials bacterial pathogen biofilm bypass Candida Candida albican Candida albicans Cell cell cycle cell growth cell proliferation contribute coupling dependence determinant diminished Effectiveness Express expresse expression Filamentous functional Gene Expression Genes growth implicated induce Infection infections information inhibition invasive kinase leads Medical devices Mutation occur organism pathogen Pathogens proliferation property Protein protein kinase reduced regulator Regulatory required Screen Stimulation strain Strains Target genes the cell transcription factor transcription factors wild-type [DOI] 10.1371/journal.pgen.1006487 PMC 바로가기 [Article Type] Research Article
The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σ V Activation항-시그마 인자 RsiV는 리소자임에 대한 박테리아 수용체입니다: 공결정 구조 결정 및 RsiV에 대한 라이소자임의 결합이 σ V 활성화에 필요하다는 입증Research Article Published on 2016-09-072022-09-17 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence acting activate activated Activation active site addition Bacteria Bacterial bind binding cascade Cell cell wall cleavage cleave complex crystal structure Defense demonstrated demonstration Determination enzymatic activity enzyme Evidence Factor function functions Gram-positive bacteria inhibit inhibitor initiated innate immune lysozyme many case mutant promoter protease Proteases Protein proteolytic receptor regulated required resistance mechanisms RIP RNA polymerase sensor signal Signal transduction specificity Structure suggested susceptible Target genes the cell These data thought Trigger triggering triggers X-ray [DOI] 10.1371/journal.pgen.1006287 PMC 바로가기 [Article Type] Research Article
A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive보존된 DNA 반복은 게놈 아카이브에서 트리파노소마 브루세이 표면 항원의 다양한 레퍼토리 선택을 촉진합니다Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated addition African African trypanosomiasis antigenic variation archive assumption bloodstream catastrophic Cell cell cycle Chromosomal translocation Chromosomal translocations chromosome chronic condition conserved demonstrated DNA DNA sequence Donor event expression gene conversion genetic change Genome genomic homolog homology Host Hypothesis identify implicated induce infect Infection iteration mammalian manipulation natural infection observation observé outcome parasite pathogen Pathogens promote Protein proximal Recombination recombination event reduction in Region Repeat repertoire required selected Selection sequence silent species Support surface Surface glycoprotein switching synthetic tested the cell These data transcribed translocation Trypanosoma Trypanosoma brucei Trypanosome trypanosomiasis Variant Surface Glycoprotein VSG [DOI] 10.1371/journal.pgen.1005994 PMC 바로가기 [Article Type] Research Article
Heterologous Aggregates Promote De Novo Prion Appearance via More than One Mechanism이종 골재는 하나 이상의 메커니즘을 통해 De Novo Prion 모양을 촉진합니다.Research Article Published on 2015-01-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence aggregate aggregates aggregation appear appearance asparagine Cell cells cellular chaperone characteristic Colocalization conformational cytoplasm de novo detect disease domains eukaryotic form Glutamine Heterologous Interaction lack mechanisms molecular MOST neurodegenerative no interaction open overexpressed overexpression pathway periphery phenotypic phenotypic traits physical Polymer prevalent prion promote Protein Proteins PSI required seed stimulated the cell traits vacuole variant while yeast [DOI] 10.1371/journal.pgen.1004814 PMC 바로가기 [Article Type] Research Article