Nucleocapsid Interacts with NPM1 and Protects it from Proteolytic Cleavage, Enhancing Cell Survival, and is Involved in PEDV GrowthArticle Published on 2017-01-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] activities addition binding caspase-3 Cell components cytoplasm Degradation ENhance Enhancing epidemic diarrhea growth host cell independent indicated infected cells interact Interaction knockdown mechanism N protein NPM1 nuclear translocation nucleocapsid Nucleolus nucleophosmin nucleus overexpression PEDV Prevent promoted PROTECT Protein proteolytic proteolytic cleavage Regulation replicate Replication required suppressed survival the N protein virus [DOI] 10.1038/srep39700 PMC 바로가기 [Article Type] Article
The Identification and Characterization of Two Novel Epitopes on the Nucleocapsid Protein of the Porcine Epidemic Diarrhea VirusArticle Published on 2016-12-192022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] addition Analysis Antisera cause characterization conserved contagious contribute coronavirus cross-reactivity death diagnostic diarrhea epidemic diarrhea epitope Freeze-thaw cycle hyperimmune identification IFA indicated indirect immunofluorescence intrinsically monoclonal antibody N protein Neonatal novel nucleocapsid protein overlapping PEDV protease residue screened significantly strain TGEV the N protein Treatment virus [DOI] 10.1038/srep39010 PMC 바로가기 [Article Type] Article
Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious DiseasesResearch Article Published on 2015-12-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] alleles Analysis B-cell B-cell epitope candidate Cellular immune response Coverage CTL CTL epitope CTL epitopes cytotoxic T lymphocyte Diseases dominant effective elicit epitope helper T-cell epitope helper T-cell epitopes HLA binding Immune Epitope Database Immunity immunogen induce Infectious disease linear majority mapped MERS MERS-CoV Middle East neutralizing antibody nucleocapsid pandemic pathogen peptide Population Protective protective neutralizing antibody Protein provide public health Region respiratory syndrome coronavirus screened Screening screening strategy selected sequence T-cell T-cell Response target the N protein Vaccine vaccine candidates Vaccine development was performed [DOI] 10.1371/journal.pone.0144475 PMC 바로가기 [Article Type] Research Article
The Nucleocapsid Protein of Human Coronavirus NL63Research Article Published on 2015-02-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis binding C-terminal domain Cell cell cycle progression cellular processes Characteristics Coronaviral coronavirus described disease expressing feature Genetic genomes HCoV-229E HCoV-NL63 homologous Human human coronavirus human coronavirus 229E infected cells involved N-terminal domain NL63 nucleic acid nucleocapsid protein nucleus oligomerization other coronaviruses pathogen Protein respiratory tract responsible reveal SARS-CoV severity subcellular localization the N protein transfected cells unique viral replication [DOI] 10.1371/journal.pone.0117833 PMC 바로가기 [Article Type] Research Article
The Coronavirus Nucleocapsid Is a Multifunctional ProteinReview Published on 2014-08-072022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] complexes coronavirus coronavirus assembly coronavirus N Critical Efficiency form function genomic RNA highlight interact intracellular localization multifunctional protein nucleocapsid nucleocapsid protein Protein protein topology recent the N protein Transcription viral membrane virion assembly virus [DOI] 10.3390/v6082991 PMC 바로가기 [Article Type] Review
Molecular Characterizations of Subcellular Localization Signals in the Nucleocapsid Protein of Porcine Epidemic Diarrhea VirusArticle Published on 2014-03-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid antibiotic Cell cellular characterization chromosome CHROMOSOME region maintenance 1 confocal microscopy coronavirus Critical cytoplasm epidemic diarrhea eukaryotic fluorescent full-length functional fusion protein GFP Infection inhibited Localization Mutation N protein NES nuclear nuclear export signal nucleocapsid nucleocapsid protein Nucleolus pathway PEDV Porcine epidemic diarrhea virus Protein signal site-directed mutagenesis subcellular localization signals the N protein VERO E6 cells virus virus replication [DOI] 10.3390/v6031253 PMC 바로가기 [Article Type] Article
Fine level epitope mapping and conservation analysis of two novel linear B-cell epitopes of the avian infectious bronchitis coronavirus nucleocapsid proteinArticle Published on 2012-11-012022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] acute infection After alignment amino acid sequence Analysis antigenic structure assay Avian infectious bronchitis Cell-mediated immunity conserved coronavirus cross cross-reactive antibody diagnostic diagnostics epitope epitope mapping Epitopes facilitate Heterologous IBV immunogens indicated induce infections infectious Infectious Bronchitis Virus Influenza virus isolate linear B-cell epitope mAb mAbs monoclonal antibody N protein newcastle disease virus nucleocapsid nucleocapsid protein peptide Phylogenetic analysis PROTECT Protein Replication Respiratory disease sequence serotypes Strains the N protein translation viral particle Viral RNA virus [DOI] 10.1016/j.virusres.2012.10.028 PMC 바로가기 [Article Type] Article