Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2, the etiologic agent of COVID-19 pandemic: an in silico approachBioinformatics Published on 2020-07-272022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome antigenic epitope applied approach average B-cell epitope binding bioinformatics candidate vaccine chimeric Chimeric Peptide Vaccine codon optimization coronavirus coronavirus disease Coverage COVID-19 Cytokines demonstrated docking E protein Ethnic groups expression IFN-γ IgG1 IgG2 IgM IL-2 Immune receptor immune response in silico Approach International mRNA Muti-epitope pandemic peptide predicted proliferation Proteins public health emergency SARS-CoV-2 secondary structure T-cell T-cell epitope T-helper cell TLR3 TLR4 Vaccine vaccine candidate Vaccine design WHO World Health Organization [DOI] 10.7717/peerj.9572 PMC 바로가기 [Article Type] Bioinformatics
Designing Multi-Epitope Vaccines to Combat Emerging Coronavirus Disease 2019 (COVID-19) by Employing Immuno-Informatics ApproachImmunology Published on 2020-07-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 3D model ACE2 addressed adjuvants alleles Analysis analyzed B-cell epitopes caused changes in China combat corona vaccine coronavirus COVID-19 domain epitope evaluate evaluated HLA Host immunogenic Interaction linker Multi-epitope vaccine pandemic physiochemical property Predictive Receptor binding S1 and S2 S1 domain S2 domain SARS-coronavirus SARS-CoV-2 single-stranded RNA virus Spike protein Spike proteins T-cell the spike protein therapeutic TLR2 TLR4 Vaccine vaccine candidate vaccine construct viral entry [DOI] 10.3389/fimmu.2020.01663 PMC 바로가기 [Article Type] Immunology
The cholinergic anti-inflammatory pathway alleviates acute lung injuryCommentary Published on 2020-06-292022-10-30 Journal: Molecular Medicine [Category] Coronavirus, SARS, [키워드] activated acute lung injury administration airway ALI alleviate Anti-inflammatory antiinflammatory ARDS Blood circulation COVID-19 dying cell expression Extracellular HMGB1 GTS-21 HMGB1 HMGB1 receptor HMGB1 release HMGB1-partner molecule complex hyperoxia indicated inflammatory lung injury inhibiting innate immunity cell Lung injury mechanism Medicine Nicotine nuclear protein Pathogenesis pathway plasma Pneumonia promote inflammation pulmonary inflammation RAGE receptor reduction released reported retained severe COVID-19 sterile origin systemic HMGB1 TLR4 Vagus nerve stimulation venous [DOI] 10.1186/s10020-020-00184-0 PMC 바로가기 [Article Type] Commentary
Insight Into TLR4-Mediated Immunomodulation in Normal Pregnancy and Related DisordersTLR4 매개 면역 조절에 대한 통찰력: 정상 임신 및 관련 장애에서Review Published on 2020-05-192024-08-11 Journal: Frontiers in immunology [Category] 말라리아, [키워드] Innate immunity Pregnancy Preterm birth pro-inflammatory TLR4 [DOI] 10.3389/fimmu.2020.00807 PMC 바로가기 [Article Type] Review
Hepatitis B virus‐induced hyperactivation of B cells in chronic hepatitis B patients via TLR4Original Article Published on 2020-05-112023-06-03 Journal: Journal of Cellular and Molecular Medicine [Category] B형 간염, [키워드] B cell hyperactivation Chronic Hepatitis B NF‐κB pathway TLR4 [DOI] 10.1111/jcmm.15202 PMC 바로가기 [Article Type] Original Article
Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathwayArticle Published on 2020-05-082022-11-01 Journal: International immunopharmacology [Category] Coronavirus, [키워드] Activation alleviate anti-inflammatory agent antibody clinical setting cured cytokine deficiency disease downstream Glycyrrhetinic acid glycyrrhizic acid hepatic injury Hepatitis HMGB1 HMGB1 release human disorder hydrolysis immunological in viral Infection Infectious disease Inflammation Inflammatory Inflammatory diseases Inflammatory response ingredient inhibit inhibited injection Injury involved licorice mechanism MHV mice murine murine hepatitis virus Neutralizing neutralizing antibody occur provide Regulation reported Signaling signaling pathway significantly TCM the cytokine storm therapy TLR4 Treatment triggered variety Viral hepatitis viral-induced [DOI] 10.1016/j.intimp.2020.106578 PMC 바로가기 [Article Type] Article
Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?세포외 HMGB1: 코로나19를 포함한 중증 폐염증 치료 표적?Review Published on 2020-05-072022-08-13 Journal: Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease activated activated innate immunity cells acute respiratory distress acute respiratory distress syndrome Apoptosis ARDS Blood cause cells from males cellular cytosol complexes concentrations coronavirus disease COVID-19 COVID-19-associated inflammation cytokine cytosolic DAMP DAMPs danger molecule Danger molecules detrimental disease Disulfide Disulfide-HMGB1 dying cell dying cells endocytosed endocytosis endogenous damage-associated molecular pattern endolysosomal system endothelial cells expressed expression Extracellular extracellular DNA Extracellular HMGB1 extracellular SARS-CoV-2 RNA female form HMGB1 identify in vivo individuals induce inflammasome activation Inflammation Influenza initiate innate immunity cells lung Lungs lysosome Lysosomes lytic cell death molecular molecule HMGB1 Necrosis Novel coronavirus novel coronavirus disease observation other molecules PAMP PAMPs pathogen pathogen-associated molecular Pathogenesis pathogenic molecule Pathways physiological plasma Pneumonia pro-inflammatory cytokine pro-inflammatory cytokine release proinflammatory receptor pulmonary endothelial cell pulmonary endothelial cells pulmonary inflammation RAGE reduction released respiratory distress Respiratory distress syndrome RNA SARS-CoV-2 secreted syndrome Therapeutic compounds therapeutic target therapy TLR4 TLR4 receptor TLR4 receptors transfer transported Trigger triggers venous venous blood [DOI] 10.1186/s10020-020-00172-4 PMC 바로가기 [Article Type] Review
Glycyrrhizin Inhibits PEDV Infection and Proinflammatory Cytokine Secretion via the HMGB1/TLR4-MAPK p38 PathwayArticle Published on 2020-04-232022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] Activation addition antibody cytokine secretion demonstrated epidemic diarrhea Extracellular GLY glycyrrhizin had no HMGB1 indicated Infection inhibited JNK kinase knockdown MAPK MAPK p38 mechanism mRNA level mRNA levels Mutation N-terminal participated pathway PEDV PEDV infection Phosphorylation Proinflammatory cytokine proinflammatory cytokines Protein regulated secretion TLR4 toll-like receptor 4 virus [DOI] 10.3390/ijms21082961 PMC 바로가기 [Article Type] Article
Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational developmentResearch paper Published on 2020-04-022022-11-01 Journal: EBioMedicine [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV agonists antibody antigen-specific antibody building characteristic clinical development clinical trials coronavirus Coronavirus infection COVID-19 COVID-19 disease COVID-19 vaccines develop Diseases domain effort elicited ELISA evidenced finding fused Health immune immune response immunization immunogenicity in vivo induce infectious agent injection long-lasting MERS MERS-CoV MERS-CoV S1 MERS-CoV vaccine MERS-CoV vaccines mice Microneedle microneedle array Middle East MNA MOST Novel coronavirus Outbreaks Pandemics produced Progressive Protein protein subunit vaccine respiratory response responses SARS-CoV SARS-CoV-2 SARS-CoV-2 S1 sequence serum specific IgG antibody subcutaneously Subunit vaccine subunit vaccines Support tested the SARS-CoV-2 TLR4 TLR5 translational trimeric trimerization Vaccine variant viral envelope virus virus neutralization assays [DOI] 10.1016/j.ebiom.2020.102743 PMC 바로가기 [Article Type] Research paper
Ethyl pyruvate protects against Salmonella intestinal infection in mice through down-regulation of pro-inflammatory factors and inhibition of TLR4/MAPK pathwayarticle Published on 2019-06-302024-09-01 Journal: International Immunopharmacology [Category] 살모넬라증, [키워드] Ethyl pyruvate intestinal immunity MAPK Salmonella Typhimurium TLR4 [Article Type] article