Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: Evaluation of 5676 Phase 1 Passed Structures시험관내 항SARS-CoV-2 활성에 대한 고처리량 스크리닝 분석의 개발 및 최적화: 5676 1상 통과 구조 평가Clinical Trial Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus African green monkey anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral Antiviral agents Caco-2 can not cell lines Chloroquine clinical development clinical trials clinically Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 treatment development Doxorubicin drug effective enhanced green fluorescent protein epithelial cell epithelial cells expressing fluorescent green fluorescent protein green monkey Hydroxychloroquine in vitro inhibitor inhibitors itraconazole kidney library nelfinavir outbreak pandemic pharmacokinetic data Phase 1 Protein Remdesivir SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection strain Strains Structure Support these compound these compounds Toxicity Treatment Vaccine Vaccines VeroE6-eGFP cells virus was used [DOI] 10.1002/jmv.27683 PMC 바로가기 [Article Type] Clinical Trial
The Role of Vitamin D in SARS-CoV-2 Infection and Acute Kidney InjurySARS-CoV-2 감염 및 급성 신장 손상에서 비타민 D의 역할Review Published on 2022-07-012022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition AKI alveolar Anti-inflammatory Anti-inflammatory effects antioxidant benefit broad spectrum calcium Cell cell metabolism Chronic kidney disease CKD contribute Control coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 severity Critically ill Critically ill patient critically ill patients cytokine release deficiency described Effects endothelial damage essential nutrient Genes homeostasis hormone in-hospital mortality Infection influence Innate immunity involved Kidney disease manifestation mechanism metabolism mitochondrial modulation molecular Mortality non-genomic nuclear outcome Pathologies Pathways phosphate proinflammatory recruitment regulate risk role SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe coronavirus disease Side effects targets therapeutic strategy Toxicity Transcription Vitamin Vitamin D vitamin D deficiency vitamin D level vitamin D serum Vitamin D supplementation [DOI] 10.3390/ijms23137368 PMC 바로가기 [Article Type] Review
Anti-COVID-19 potential of Azadirachta indica (Neem) leaf extractReview article Published on 2022-07-012022-10-05 Journal: Scientific African [Category] 신약개발, 임상, [키워드] acute phase acute respiratory syndrome addition Affect age Azadirachta indica benefit binding Brain C-reactive protein cancer cell cardiovascular disease caused chemokines clinical trial Comorbidity complications COVID-19 Cytokine storm Cytokines detectable diabete displacement distress effective Extract extreme favor HIV hyper-inflammation Infection investigated kidney liver Lungs malaria MERS Middle East MODS morbidity and mortality multiple organs nitric oxide obesity organ oxidative stress Population positioned positive Prevent pro-inflammatory Protein reactive oxygen species red blood cell risk factor RNA SARS-CoV SARS-CoV-2 Severe case severe COVID-19 single-stranded syndrome T lymphocytes therapeutic Toxicity turn unique Vascular Vascular endothelium virus yielding [DOI] 10.1016/j.sciaf.2022.e01184 [Article Type] Review article
Essential oil nebulization in mild COVID-19(EONCO): Early phase exploratory clinical trialResearch article Published on 2022-07-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 임상, [키워드] Anosmia antiviral action appear approach Asymptomatic benefit carried clearance clinical trial Combination Concentration coronavirus disease COVID-19 doses Efficacy essential oil Eucalyptus oil evaluated Evolution exploratory frequencies Inconclusive Mild multiple ascending dose objective Open-label participant Peppermint oil phase Placebo polymerase chain produced Randomized reached reduced respiratory symptom Result reverse transcription Safety significantly Steroids study participant Symptom symptomatic Symptomatic relief Tea tree oil Therapeutic benefit therapeutic efficacy Toxicity Treatment Viremia with mild disease [DOI] 10.1016/j.jaim.2022.100626 [Article Type] Research article
Development of COVID-19 therapies: Nonclinical testing considerationsCOVID-19 치료법 개발: 비임상 테스트 고려 사항Article Published on 2022-07-012022-09-12 Journal: Regulatory toxicology and pharmacology : RTP [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료제, [키워드] agency antibody authorization Candidates COVID-19 development Emergency EUA mAb monoclonal monoclonal antibody neutralization Nonclinical occurred pathway Patient performed pharmacokinetic platform Recognition reduced Regulatory Result SARS-CoV-2 small molecule Small molecules the spike protein therapy Toxicity Treatment USA utility vaccination Vaccine Vaccines [DOI] 10.1016/j.yrtph.2022.105189 PMC 바로가기 [Article Type] Article
A pilot phase Ib/II study of whole-lung low dose radiation therapy (LDRT) for the treatment of severe COVID-19 pneumonia: First experience from AfricaClinical Trial Published on 2022-07-012022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] 24 hour absence benefit cellular proliferation clinical benefit clinical trial Complete condition conducted COVID-19 CRP Cytokine storm D-dimer Day death defined demonstrated died discharge discharged dose Efficacy elevated enrolled feasibility feasible fraction High-resolution HRCT identify Inflammatory marker inhibit investigator-initiated Kenya low dose lung management mechanical ventilation median time on mechanical ventilation oxygen Oxygen requirement Oxygenation Patient patients PCR Pneumonia polymerase chain primary endpoint progressed radiation therapy remained resources SAE Safe secondary endpoint Sepsis severe COVID-19 Severe COVID-19 pneumonia the patient therapy Toxicity treat treated Treatment Trial university Vaccine were excluded [DOI] 10.1371/journal.pone.0270594 PMC 바로가기 [Article Type] Clinical Trial
Repurposing antiviral phytochemicals from the leaf extracts of Spondias mombin (Linn) towards the identification of potential SARSCOV-2 inhibitors잠재적인 SARSCOV-2 억제제의 식별을 위해 스폰디아스 몸빈(Spondias mombin, Linn)의 잎 추출물에서 항바이러스 파이토케미컬을 용도 변경Article Published on 2022-06-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 3CL pro absence acute respiratory symptoms acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-viral Antiviral approved approved drug approved drugs binding free energy candidate Compound coronavirus 2 disease domain Dynamics exhibited free energy in vitro in vivo indicated inhibitor inhibitors investigated molecular dynamics molecular dynamics simulations momentum pattern persistence polymerase protease public health RBD Receptor-binding domain reported repurposing respiratory S-protein SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spondia target the SARS-CoV-2 therapeutic Toxicity Vaccine vaccine availability Vaccine hesitancy viral mutation [DOI] 10.1038/s41598-022-14558-3 PMC 바로가기 [Article Type] Article
Novel Galactopyranoside Esters: Synthesis, Mechanism, In Vitro Antimicrobial Evaluation and Molecular Docking Studies새로운 갈락토피라노사이드 에스테르: 합성, 메커니즘, 시험관 내 항균성 평가 및 분자 도킹 연구Article Published on 2022-06-272022-09-12 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 6LU7 activity ADMET studies antifungal agents antimicrobial antimicrobial agents antiviral drugs Aspergillus fumigatus binding energy Bioavailability catalyzed conducted distribution drug-likeness dynamics simulation in vitro indicated inhibitor metabolism methyl α-D-galactopyranoside esters molecular molecular docking novel one-step acylation. PDB produced protease reactivity SARS-CoV-2 sequence supported synthesis the SARS-CoV-2 these compound Toxicity [DOI] 10.3390/molecules27134125 PMC 바로가기 [Article Type] Article
An interrupted time series analysis of hospital admissions due to alcohol intoxication during the COVID‐19 pandemic in Tehran, Iran Research Published on 2022-06-222022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료법, [키워드] affected age alcohol alcohol poisoning all age group Analysis children COVID-19 COVID-19 epidemic COVID-19 outbreak COVID-19 pandemic COVID‐19 diagnosed ethyl alcohol evaluate evaluated hospital Hospital admission Hospitalized incidence increases in Interrupted Iran mental health methanol methyl alcohol Mortality non-toxic occurred outbreak pandemic Patient patient data patients resulting significant increase significantly higher Tehran Toxicity Treatment trend was increased [DOI] 10.1038/s41598-022-14799-2 [Article Type] Research
Multi-Step In Silico Discovery of Natural Drugs against COVID-19 Targeting Main Protease주요 프로테아제를 표적으로 하는 COVID-19에 대한 천연 약물의 다중 단계 In Silico 발견Article Published on 2022-06-212022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] 6LU7 Antiviral compounds binding affinities binding mode carried co-crystallized Compound compounds COVID-19 docking drug eight Election exhibited experiment in silico inhibit SARS-CoV-2 inhibitor Ligand M pro main protease MD simulations MM-PBSA molecular molecular docking molecular fingerprints multi natural PDB performed profiles protease SARS-CoV-2 main protease similarity step Streptovaricin structural similarity targeting Toxicity was done was performed [DOI] 10.3390/ijms23136912 PMC 바로가기 [Article Type] Article