Conjugated bilirubin affects cytokine profiles in hepatitis A virus infection by modulating function of signal transducer and activator of transcription factorsArticle Published on 2014-12-012023-05-31 Journal: Immunology [Category] A형 간염, Fulltext, [키워드] Bilirubin hepatitis A virus signal transducer and activator of transcription protein transcription factors Viral hepatitis [DOI] 10.1111/imm.12336 PMC 바로가기
The Drosophila MAPK p38c Regulates Oxidative Stress and Lipid Homeostasis in the IntestineDrosophila MAPK p38c는 장의 산화 스트레스와 지질 항상성을 조절합니다Research Article Published on 2014-09-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Analysis analyzed antimicrobial peptide Atf3 Bacterial infection cassette cellular Control digestive tract Drosophila ENCODE enzyme expressed expressing expression function gene encoding genetic analysis Genome Gut Human Immune homeostasis Immunity implicated induce Infection intestinal intestine involved kinase kinases Lipid lipid metabolism lipids MAPK Mekk1 metabolic genes metabolism midgut mutant mutants observation oxygen pathogen pathway peptide phenotype phosphorylate Phosphorylation physical Protein protein kinase protein kinases Pseudomona reactive oxygen species reduced regulate reveal ROS Signaling signaling pathway Specy Stress substrates susceptible Transcription transcription factor transcription factors up-regulated upregulated variety yeast [DOI] 10.1371/journal.pgen.1004659 PMC 바로가기 [Article Type] Research Article
Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause RegionsHIV-1 및 프로모터-근위 일시 중지 영역에서 NELF-E RNA 결합 정의Research Article Published on 2014-01-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major addition analyzed association Author binding binding activity binding domain Biochemistry cellular claimed compared complex Consensus conserved contribute downstream Drosophila elongation elongation factor eukaryotic facilitate Factor functional Gene Genes Genome high affinity HIV-1 identify in addition to in vitro Interaction modulate molecular negative nuclear nucleotide nucleotides observé pause POLL promoter Protein protein coding gene protein coding genes Protein subunit Quantitative Recognition Region regulate regulated Regulatory required responsible RNA RNA Polymerase II RNA sequence RNA sequences sequence significant increase subunit Support targets thought transcribed Transcription transcription factor transcription factors transcription start site widespread [DOI] 10.1371/journal.pgen.1004090 PMC 바로가기 [Article Type] Research Article
A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors출생 후 멜라닌 세포 계통의 유지와 멜라닌 세포 줄기 세포 전구체의 분화에서 SOX10의 이중 역할Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult stem cells appear Author cause Cell cell fate cell type Critical differentiation downregulated downstream driving embryogenesis exacerbate examined Express expression Factor growth hair hair follicle haploinsufficiency idea in vivo increased expression leads Lineage maintain maintenance mechanism Melanocyte melanocytes melanogenesis MITF mitigate Mouse models negative regulation observation overexpression pigment portion precursor Premature prevented progenitor raise regulated Regulation Regulatory role Sox10 STEM stem cell stem cells survival sustained target Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1003644 PMC 바로가기 [Article Type] Research Article
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다Research Article Published on 2013-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer [DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article
MTL –Independent Phenotypic Switching in Candida tropicalis and a Dual Role for Wor1 in Regulating Switching and FilamentationMTL – Candida tropicalis의 독립적인 표현형 전환과 전환 및 필라멘트 조절에서 Wor1의 이중 역할Research Article Published on 2013-03-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition ascomycete Author C. albican C. albicans Candida albican Candida albicans Candida tropicalis Cell cell type cell types cells characterized colonization conserved Deletion dependent on different Efficiency Epigenetic expression filament fungal fungi Gene growth heterozygous homozygous Host in addition to independent independent of induce Infection Interaction locus mammalian master regulator overexpression overlap pathogen pathogenic phenotypic Program promote regulate regulated Regulating Regulation related retained reveal role sexual reproduction switching these cell These cells transcription factor transcription factors transcriptional regulator transition undergo white cell white cells Wor1 yeast form [DOI] 10.1371/journal.pgen.1003369 PMC 바로가기 [Article Type] Research Article
SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatusSREBP는 인간 곰팡이 병원체 Aspergillus fumigatus에서 트리아졸 약물 및 저산소증 반응을 중재하기 위해 철과 에르고스테롤 항상성을 조정합니다Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. fumigatus acquisition activated adaptation Adding addition advance Aspergillus fumigatus Author binding Candida albican Candida albicans caused cellular response class clinically condition conditions Coordinate Critical Cryptococcus neoforman Cryptococcus neoformans decrease dependent on drug drug susceptibility drugs ergosterol eukaryotes found foundation fungal fungal infections fungal pathogen Gene Genetic growth growth defect Health Human hypoxia hypoxic identify immunocompromised condition infections initial involved iron iron homeostasis Iron metabolism led to lethal disease majority mechanism metabolism microenvironment Most patients mRNA mutant mutants pathogenic Pathogens Patient phenotype Protein regulate Regulation regulatory element required response restoration Sterol Support susceptibility susceptible These data transcription factor transcription factors triazole virulence [DOI] 10.1371/journal.pgen.1002374 PMC 바로가기 [Article Type] Research Article