transcriptomics – Page 10 – Communicable Diseases Research

Transcriptomics and RNA-Based Therapeutics as Potential Approaches to Manage SARS-CoV-2 Infection

Article

Published on 2022-09-212022-11-16
Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, 치료기술,

Transcriptomics, Cheminformatics, and Systems Pharmacology Strategies Unveil the Potential Bioactives to Combat COVID-19

Article

Published on 2022-09-132022-11-16
Journal: Molecules [Category] SARS, 유전자 메커니즘,

[키워드] addition Analysis analyzed approach caused Cheminformatics co-expression combat Complete COVID-19 determine disease drug candidate Efficiency Features functional Genetic higher efficiency identify immune immune gene Infection Laboratory lack mechanism molecular molecular docking molecular docking analysis Mutation pathway enrichment pharmacological Pharmacology Phytocompounds plant plants Potential Prevalence Regulation required SARS-CoV-2 selected Side effects Signaling Strategy System systems pharmacology. the SARS-CoV-2 virus therapeutic these compound transcriptomics transmission rate treat unique unique genes Vaccinations viral disease
[DOI] 10.3390/molecules27185955 PMC 바로가기

A bacterial pan-genome makes gene essentiality strain-dependent and evolvable

세균 팬 유전체는 유전자 필수성을 균주 의존적이고 진화 가능하게 만든다.

Article

Published on 2022-09-122024-08-23
Journal: Nature Microbiology [Category] 폐렴구균 감염증,

[키워드] Bacterial genetics epistasis Mutagenesis Next-generation sequencing transcriptomics
[DOI] 10.1038/s41564-022-01208-7 PMC 바로가기

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury

Article

Published on 2022-09-092022-11-15
Journal: Genome Medicine [Category] 유전자 메커니즘, 진단,

[키워드] Acute kidney injury adverse outcomes affected AKI Cell cell type changes in characterized Control COVID-19 criteria Critical Critical illness Critically ill patient diagnosed with COVID-19 disease disease-associated distal epithelial Gene Expression heterogeneity highlighting histology human kidney humans hypoxia Improving individual Injury inter-individual interferon response KDIGO kidney Kidney injury kidney tissue limbs mechanism molecular molecular responses occur oxidative stress performed Post-mortem provide proximal resource respiratory infections response reveal Sequencing single-cell sequencing Single-cell transcriptomics subtype Therapies Transcriptome transcriptomic transcriptomics
[DOI] 10.1186/s13073-022-01108-9 PMC 바로가기

Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions

Article

Published on 2022-09-082022-11-16
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료기술,

Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain

Article

Published on 2022-09-022022-11-16
Journal: Journal of Proteome Research [Category] COVID19(2023년), SARS, 유전자 메커니즘,

Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination

Article

Published on 2022-09-022022-11-16
Journal: Frontiers in Immunology [Category] SARS, 변종,

RNA sequence analysis of nasopharyngeal swabs from asymptomatic and mildly symptomatic patients with COVID-19

Research article

Published on 2022-09-012022-10-05
Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] Analysis Asymptomatic autophagy Bacterial Cell changes in Coinfection complement COVID-19 Differential gene expression disease severity dysregulation Epigenetic gene expression profile Gene ontology group identify in both group investigated involved mildly symptomatic patient Modification modulation mRNA Nasopharyngeal swab objective outcome Patient patients performed profile progression proportion reduction in Result retrieved RNA RNA sequence SARS-CoV-2 SARS-COV-2 infection Sequence analysis Sequencing Streptococcus pneumoniae symptomatic symptomatic individuals Symptomatic patients the disease transcriptomic transcriptomics translation Transport upregulation Viral genome assembly viral variant with COVID-19
[DOI] 10.1016/j.ijid.2022.06.035 [Article Type] Research article

In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19

통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈

Article

Published on 2022-09-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics up-regulated USP18 viral infectious disease
[DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article

Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection

Article

Published on 2022-09-012022-11-15
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 진단,