Deletion of the SARS-CoV-2 Spike Cytoplasmic Tail Increases Infectivity in Pseudovirus Neutralization Assays
Vaccines and Antiviral Agents
[키워드] acute respiratory syndrome
amino acids
antibody
Antibody therapeutics
approach
Biosafety Level 3
BSL2
BSL3
Cell
Characteristics
coronavirus
coronavirus disease
COVID-19
COVID-19 pandemic
Critical
cytoplasmic tail
defined
Deletion
facilitate
full-length
generate
hACE2
human ACE2
Humoral immunity
IgG
increase
Infectivity
inhibitor
lentiviral
Lentiviral vector
limit of detection
log
murine
Neutralization assay
Neutralizing antibodies
pandemic
Precision
produced
pseudovirion
pseudovirus
Pseudovirus neutralization assay
purified
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 pseudovirus
SARS-CoV-2 spike
SARS-CoV-2 variant
sensitivity
sera
spike
Spread
tail
target cells
the SARS-CoV-2
vaccination
Vaccine
variant
viral entry
viral pathogen
virulent
virus
virus entry
[DOI] 10.1128/JVI.00044-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
[DOI] 10.1128/JVI.00044-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents