Using a “systems therapeutic for physiological renormalization” approach to vaccine development. Covid-19 as an example백신 개발에 "생리학적 재정규화를 위한 시스템 치료" 접근 방식을 사용합니다. 코로나19를 예로 들어Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] 변종, [키워드] adaptive immune system approach current example induce infectious agent mimicry Mutation physiological Prevent Recombination replicate respiratory tract respiratory tracts sera Spread the disease therapeutic Vaccine Vaccine development variant virions virulent [DOI] 10.1080/21645515.2022.2043105 PMC 바로가기 [Article Type] Article
B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman PrimatesArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addition Alpha animal model association B.1.351 Beta caused changes in Characteristics Chinese circulating Clinical signs contribute determine distribution drugs early stage Efficacy and safety elevated exhibited IFN-γ IL-17 Infection Inflammatory Inflammatory cytokine interferon gamma interleukin 17 investigated less Lower respiratory tract lung tissue mechanisms mutated Necrosis NHP NHPs nonhuman primate pathogenesis of SARS-CoV-2 pathogenic pathogenicity pathological changes primate provide pulmonary inflammation reduced replicated Research rhesus macaque SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe lung injury shedding spike-specific T-cell response strain Strains tissue TNF-α Transmission upper respiratory tract Vaccine variant variants of concern viral distribution viral shedding virulence virulent VoC VOCs were infected [DOI] 10.1128/spectrum.02263-22 PMC 바로가기
Epidemiological characteristics of Omicron and Delta SARS-CoV-2 variant infection in Santiago, ChileArticle Published on 2022-10-212022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] B.1.617.2 Care Characteristics Chile circulating Cohort Complete contagious contagiousness COVID-19 pandemic death decrease Delta delta variant described disease distress effective epidemiological Epidemiology Health health center Hospitalization hospitalizations increase in indicate indicated Infection less omicron pandemic Patient Prevalence preventing infection proportion reported SARS-CoV-2 SARS-CoV-2 variant severity Severity of infection vaccination vaccination schedule variant variants virulent VoC with COVID-19 [DOI] 10.3389/fpubh.2022.984433 PMC 바로가기
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Hydrothermal assisted biogenic synthesis of silver nanoparticles: A potential study on virulent candida isolates from COVID-19 patientsArticle Published on 2022-10-062022-11-15 Journal: PLoS ONE [Category] 진단, [키워드] atomic biological activity Candida Candida albican Candida albicans Cell cell membrane coated COVID-19 COVID-19 patient effective Fourier transform High-resolution Ion isolate mechanism Microscopy Modification Morphological PCR question reduction silver nanoparticle TEM Testing thymus Till transmission electron microscopy virulence virulent vulgaris [DOI] 10.1371/journal.pone.0269864 PMC 바로가기
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challengeArticle Published on 2022-10-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] amino acid change antibody B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.427 B.1.429 B.1.617.1 B.1.617.2 Beta Combination D614G mutation Delta disease severity domain E484K evaluated expressing Gamma greater highlight human-to-human transmission induce L452R Lineage lineages mice moderate mouse-adapted SARS-CoV-2 mRNA vaccine Multiple multiple mutations Mutation mutations N439K N501Y neutralization neutralized Neutralizing activity neutralizing antibody observation omicron other variant P.1 P681R pandemic PROTECT Protein pseudotyped pseudovirus reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants serum antibody T478K the S protein Transmissibility vaccination Vaccine variant variants virulent [DOI] 10.1016/j.trsl.2022.04.007 PMC 바로가기
Progress in Biosensors for the Point-of-Care Diagnosis of COVID-19Article Published on 2022-09-292022-11-15 Journal: Sensors (Basel, Switzerland) [Category] SARS, 진단, [키워드] antibody Antigen approach biosensor caused composed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis Diagnosis genetic information handheld assay immunosensor Infection Laboratory lateral flow lateral flow immunoassay Lateral flow tests pandemic platform point-of-care point-of-care diagnostic test point-of-care test Progress recent SARS-CoV-2 selective specific antibody Spread the disease virulent virus [DOI] 10.3390/s22197423 PMC 바로가기
Two Years into the COVID-19 Pandemic: Lessons LearnedArticle Published on 2022-09-092022-11-16 Journal: ACS Infectious Diseases [Category] SARS, 변종, [키워드] acute respiratory syndrome caused Clinical features clinical manifestations coronavirus coronavirus disease Coronaviruses COVID-19 Diagnosis disease Epidemiology etiology global public health highlighting highly pathogenic hosts impacted IMPROVE knowledge lesson management pathophysiology prevention public health authority reservoir hosts Respiratory disease SARS-CoV-2 selected Topic Transmission Treatment Vaccines variants virulent virus widespread Wuhan, China Year [DOI] 10.1021/acsinfecdis.2c00204 PMC 바로가기
SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants eraArticle Published on 2022-09-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] Affect Asymptomatic available data B.1.1.529 B.1.617.2 caused children clinical manifestation clinical manifestations Complication conditions coronavirus disease country COVID-19 Delta delta variant Direct drastic exacerbating Google Scholar Health highest highlight Hospitalization immune response Immunodepressive incidence Infant Infants infected children Infection Manifestations Mild MIS MIS-C occur omicron Omicron variant pandemic pediatric Prevalence prevalence of COVID-19 proportion reported Risk factors SARS-COV-2 infection Science suggested symptomatic SARS-CoV-2 infection Symptoms the United State Transmission dynamics vaccination variant variants virulent [DOI] 10.1186/s12985-022-01873-4 PMC 바로가기
Identification of SARS-CoV-2 Variants of Concern Using Amplicon Next-Generation SequencingArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accuracy Amplicon amplified Beta caused clinical sample concern correlation COVID-19 Delta described develop died DNA sequence eight genomes genotyping GISAID identification include isolate Local manuscript Mutation mutations Next-generation sequencing NGS nine omicron one-step PCR pandemic patients PCR public health Rapid RNA RNA sample SARS-CoV-2 sequenced Seven Spearman Spike protein tested the SARS-CoV-2 the spike protein Treatment vaccination variant variants variants of concern variants of concern (VOC) variants of interest Variants of interest (VOI). virulent VoC VOCs was used website were used WGS Whole-genome sequence whole-genome sequencing Wuhan isolate [DOI] 10.1128/spectrum.00736-22 PMC 바로가기