COVID-19(37) SARS-CoV-2(31) Protein(26) SARS-COV-2 infection(24) Patient(24) Vaccine(21) antibody(17) vaccination(15) Infection(15) disease(14) domain(13) lung(13) Cell(13) Immunity(13) the SARS-CoV-2(12) IgA(12) C-terminus(12) immunogenicity(12) individuals(12) induce(12) nucleocapsid(12) evaluate(12) coronavirus(11) C-reactive protein(11) Mortality(11) coronavirus disease(11) syndrome(11) Protective(10) COVID-19, Coronavirus disease 2019(10) correlated(10)
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine
Article
Published on
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), SARS, 변종, 진단,
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), SARS, 변종, 진단,
[키워드] activated
airway epithelial cells
Antigen
B cell
Beta
Cell
cross-reactive
delta variant
dendritic cell
development
domain
effective
elicited
facilitated
humoral
IgA response
immune response
Immunity
induce
Inflammation
intranasal
long-lasting
lung
mice
Microparticle
mucosal
nasal
Parenteral
porous
prime and boost
Protective
RBD
SARS-CoV-2
SARS-CoV-2 RBD
SARS-CoV-2 vaccine
subunit
type 1 helper
vaccination
Vaccinations
Vaccine
variant
Viral load
[DOI] 10.1016/j.trsl.2022.06.004 PMC 바로가기
[DOI] 10.1016/j.trsl.2022.06.004 PMC 바로가기
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge
Article
Published on
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), SARS, 변종, 진단, 치료기술,
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), SARS, 변종, 진단, 치료기술,
[키워드] amino acid change
antibody
B.1.1.529
B.1.1.7
B.1.1.7 lineage
B.1.351
B.1.427
B.1.429
B.1.617.1
B.1.617.2
Beta
Combination
D614G mutation
Delta
disease severity
domain
E484K
evaluated
expressing
Gamma
greater
highlight
human-to-human transmission
induce
L452R
Lineage
lineages
mice
moderate
mouse-adapted SARS-CoV-2
mRNA vaccine
Multiple
multiple mutations
Mutation
mutations
N439K
N501Y
neutralization
neutralized
Neutralizing activity
neutralizing antibody
observation
omicron
other variant
P.1
P681R
pandemic
PROTECT
Protein
pseudotyped
pseudovirus
reduced
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 variant
SARS-CoV-2 variants
serum antibody
T478K
the S protein
Transmissibility
vaccination
Vaccine
variant
variants
virulent
[DOI] 10.1016/j.trsl.2022.04.007 PMC 바로가기
[DOI] 10.1016/j.trsl.2022.04.007 PMC 바로가기
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy
Review article
[키워드] ACE2angiotensin-converting enzyme 2
acute respiratory distress syndrome
addressed
angiotensin-converting enzyme 2
ARDSacute respiratory distress syndrome
cells
Characteristics
clinical trials
complications
COVID-19
COVID-19 pandemic
developmental
effective
Effectiveness
Efficacy
Entry mechanism
feature
genomic
growth
highlight
Immune escape
immune response
increased risk
indicate
individual
investigated
mechanism
mechanisms
mRNA-based COVID-19 vaccine
Neonates
pathology
placental
Pregnancy
pregnant
Preterm birth
proteomic
RASRenin-angiotensin system
renin-angiotensin system
risk
SARS-CoV-2
SARS-CoV-2 disease
SARS-COV-2 infection
SARS-CoV-2severe acute respiratory syndrome coronavirus-2
severe acute respiratory syndrome coronavirus-2
Stillbirth
the vaccine
Transmissibility
Vaccine
Vaccines
variants of concern
variants of SARS-CoV-2
vector
VOCvariants of concern
[DOI] 10.1016/j.trsl.2022.08.007 [Article Type] Review article
[DOI] 10.1016/j.trsl.2022.08.007 [Article Type] Review article
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19
인터페론 경로 루푸스 위험 대립 유전자는 급성 COVID-19로 인한 사망 위험을 조절합니다
Article
Published on
Journal: Translational research : the journal of laboratory
[Category] 바이오마커, 변종, 유전자 메커니즘, 치료제,
Journal: Translational research : the journal of laboratory
[Category] 바이오마커, 변종, 유전자 메커니즘, 치료제,
[키워드] Activation
activator
acute COVID-19
age
allele
alleles
analyzed
antiviral immunity
Biomarker
Blood
BMI = body mass index
body mass
body mass index
C-reactive protein
cGMP
contribute
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 = coronavirus disease 2019
Critical
CRP = C-reactive protein
D-dimer
death
Defense
disease
domain
Effect
gain-of-function
Genetic
genetic information
genetic risk factor
Genotype
groups
Haplotype
Helicase
high risk
idea
IFIH1
IFIH1 = interferon-induced with helicase c domain 1
IFN
IFN = interferon
IFN pathway
Increased
interferon
interferon regulatory factor
IRF = interferon regulatory factor
IRF5
IRF7
IRF8
lupus erythematosus
modulate
Mortality
nucleotide
NYU = New York University
older subjects
OR = odds ratio
pathway
Patient
positive
Predictive
Primary outcome
PRKG1
PRKG1 = protein kinase cGMP-dependent 1
protective effect
Protective effects
Protein
protein kinase
Regulatory
risk
risk allele
risk factor
risk of death
significantly
Single nucleotide polymorphism
SLE
SLE = systemic lupus erythematosus
SNP = single nucleotide polymorphism
STAT4
STAT4 = signal transducer and activator of transcription 4.
subjects
Support
systemic lupus erythematosus
Transcription
troponin
Type
Type I IFN
type I interferon
variants
viral infections
York
younger patient
younger patients
[DOI] 10.1016/j.trsl.2022.01.007 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.trsl.2022.01.007 PMC 바로가기 [Article Type] Article
Post-COVID-19 patients show an increased endothelial progenitor cell production
Research article
Published on
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), SARS, 바이오마커,
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), SARS, 바이오마커,
[키워드] 6-minute walk test
6MWT6-minute walk test
abnormal increase
ACE-2Angiotensin-Converting Enzyme 2
Admission
angiotensin-converting enzyme 2
Arterial hypertension
blood circulation
BMIbody mass index
body mass index
C-reactive protein
Carbon monoxide diffusing capacity
cardiovascular complications
Cell
clinical parameter
colony
colony forming cell
Control
COVID-19
COVID-19 patient
CRPC-reactive protein
damaged
DDDimer-D
Diabetes Mellitus
Dimer-D
DLCOCarbon monoxide diffusing capacity
DLPDyslipidemia
DMDiabetes mellitus
dyslipidemia
ECFCEndothelial colony forming cell
elevated
endothelial
Endothelial colony forming cell
Endothelial dysfunction
Endothelial progenitor cell
Endothelium
EPCEndothelial progenitor cell
EPOerythropoietin
erythropoietin
evaluate
FEVForced expiratory volume
FIBFibrinogen
fibrinogen
forced expiratory volume
forced vital capacity
FVCForced vital capacity
Gender
HbHemoglobin
healthy controls
hematocrit
hemoglobin
HTAArterial hypertension
HTCHematocrit
hypertension
Injury
Isolation
lactate dehydrogenase
LDHlactate dehydrogenase
LymLymphocytes
Lymphocytes
male
Maximum ferritin
MFMaximum ferritin
no difference
PaO2
PaO2Partial pressure of oxygen
Partial pressure of oxygen
Patient
PBMC'sPeripheral blood mononuclear cells
PEPulmonary Embolism
Peripheral blood mononuclear cells
Post-COVID-19 patients
Postinfection
progenitor cell
Pulmonary embolism
recruited
Residual volume
RVResidual volume
SARS-CoV-2
SARS-COV-2 infection
significant increase
significantly
subject
the patient
TLCTotal lung capacity
Total lung capacity
Vascular
Vascular damage
[DOI] 10.1016/j.trsl.2022.01.004 [Article Type] Research article
[DOI] 10.1016/j.trsl.2022.01.004 [Article Type] Research article
An mRNA vaccine to prevent genital herpes
생식기 포진을 예방하는 mRNA 백신
Review
Published on
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), SARS, 진단,
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), SARS, 진단,
[키워드] accelerated
approach
approach
booster doses
CD4
Cell
coronavirus disease
develop
Developing
dorsal root ganglia
effective
effort
follicular
genital
HSV-1
immune responses
Immunity
induce
Infection
latency
lesion
memory B
mRNA
mRNA vaccine
neutralizing antibody
nucleoside-modified mRNA
Phase 3 trials
Prevent
Prophylactic
public health
response
robust
Safe
the vaccine
trials
trivalent
Vaccine
Vaccine development
Vaccines
while
[DOI] 10.1016/j.trsl.2021.12.006 PMC 바로가기 [Article Type] Review
[DOI] 10.1016/j.trsl.2021.12.006 PMC 바로가기 [Article Type] Review
Role of senescence in the chronic health consequences of COVID-19
Review article
[키워드] A phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes
acute COVID-19
alleviate
alterations
AMP-activated protein kinase
AMPKAMP-activated protein kinase
caloric restriction
Cell
cell removal
cellular senescence
chronic disease
consequence
contribute
Coronavirus disease 2019
COVID-19
COVID-19 symptom
COVID-19coronavirus disease 2019
COVID-FISA phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes
CRcaloric restriction
Defense
deregulated
dysfunction
Epigenetic
facility for geroscience analysis
FGAFacility for Geroscience Analysis
generate
genomic
greater
Health
ICUIntensive Care Unit
IFintermittent fasting
ill patients
Immune system dysfunction
increased risk
indicated
Infection
infections
Innate
intensive care unit
Intercellular communication
interfere
intermittent fasting
Intervention
Long-term care facility
low-grade inflammation
LTCFlong-term care facility
mammalian target of rapamycin
MCCmultiple chronic conditions
MERS-CoVmiddle east respiratory syndrome coronavirus
Middle East respiratory syndrome Coronavirus
mitochondrial dysfunction
Mortality
mTORmammalian target of rapamycin
Multimorbidity
multiple chronic conditions
NAD+nicotinamide adenine dinucleotide
nicotinamide adenine dinucleotide
nicotinamide mononucleotide
nicotinamide riboside
NMNnicotinamide mononucleotide
NRnicotinamide riboside
Older
outcome
PACSpostacute sequalae of SARS-CoV-2 infection
PAMPspathogen-associated molecular profile factors
pathogen-associated molecular profile factors
Patient
postacute sequalae of SARS-CoV-2 infection
predictor
reactive oxygen species
risk
risk factor
role
ROSreactive oxygen species
SARS-CoV-1severe acute respiratory syndrome coronavirus 1
SARS-COV-2 infection
SARS-CoV-2severe acute respiratory syndrome coronavirus 2
SARSSevere Acute Respiratory Syndrome
SASPsenescence-associated secretory phenotype
senescence-associated secretory phenotype
senescent
senescent cell
Severe acute respiratory syndrome
severe acute respiratory syndrome coronavirus 1
severe acute respiratory syndrome coronavirus 2
skilled nursing facility
SNFskilled nursing facility
susceptibility
TGNtranslational geroscience network
Translational Geroscience Network
viral infection
viral infections
while
WHOWorld Health Organization
World Health Organization
[DOI] 10.1016/j.trsl.2021.10.003 [Article Type] Review article
[DOI] 10.1016/j.trsl.2021.10.003 [Article Type] Review article
Central nervous system outcomes of COVID-19
Review article
[키워드] ACE2angiotensin converting enzyme 2
acute illness
acute respiratory distress syndrome
acute respiratory syndrome
angiotensin converting enzyme 2
approach
ARDSacute respiratory distress syndrome
caused
Central nervous system
cerebral spinal fluid
CFScerebral spinal fluid
Chitinase 3-like 1.
CNSCentral Nervous System
coronavirus
COVID-19
Critical
deaths
example
GBSGuillain-Barré syndrome
GFAPGlial Fibrillary Acidic Protein
Glial fibrillary acidic protein
Guillain-barrè syndrome
identify
Implications
Loss of Smell
manifestation
ME/CFSmyalgic encephalomyelitis/chronic fatigue syndrome
Mild
Myalgic encephalomyelitis/chronic fatigue syndrome
nervous system
neurofilament light chain
neurologic
neurological
Neurological symptom
NfLneurofilament light chain
outcome
PASC
PASCpostacute sequelae of COVID-19
pathophysiology
PCRpolymerase chain reaction
Peripheral nervous system
PNSPeripheral nervous system
polymerase chain reaction
postacute sequelae of COVID-19
reported
Research
Respiratory disease
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2severe acute respiratory syndrome coronavirus 2
Seizure
severe acute respiratory syndrome coronavirus 2
stroke
Symptom
the disease
the SARS-CoV-2 virus
these symptom
these symptoms
ubiquitin carboxyl-terminal esterase L1
UCH-L1ubiquitin carboxyl-terminal esterase L1
worldwide pandemic
YKL-40Chitinase 3-like 1.
[DOI] 10.1016/j.trsl.2021.09.002 [Article Type] Review article
[DOI] 10.1016/j.trsl.2021.09.002 [Article Type] Review article
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen
스파이크 기반 COVID-19 면역은 뉴클레오캡시드 항원에 대한 항체를 증가시킵니다
Article
Published on
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,
[키워드] antibody
Antibody Response
Antibody responses
Antigen
avidity
BNT162b2
C-terminus
COVID-19
COVID-19 vaccination
cross-reactive antibodies
cross-reactive antibody
detect
full length
Health care
health care workers
IgA
IgG level
IgG levels
immunization
immunoassay
immunogenicity
increase
increase in
individuals
Infection
MONITOR
mRNA
mRNA-1273
multiplex
N antigen
nucleocapsid
nucleocapsid antigen
Protein
S-based vaccines
SARS-CoV-2 S
Seropositivity
Subunit vaccine
subunit vaccines
suggested
the SARS-CoV-2
vaccination
Vaccine
[DOI] 10.1016/j.trsl.2021.10.004 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.trsl.2021.10.004 PMC 바로가기 [Article Type] Article
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling
SARS-CoV-2 감염으로 인한 폐 손상 모델로서의 시리아 햄스터: 병리학, 생리학 및 상세한 분자 프로파일링
Article
Published on
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), MERS, SARS, 진단,
Journal: Translational research : the journal of laboratory
[Category] COVID19(2023년), MERS, SARS, 진단,
[키워드] Acute inflammation
acute lung injury
acute respiratory distress
acute respiratory syndrome
acute SARS-CoV-2 infection
Analysis
animal model
Apoptosis
ARDS
caused
characterized
clearance
coronavirus
coronavirus disease
COVID-19
demonstrated
driving
evaluate
Evidence
exhibited
feature
Ferroptosis
hamster
histologic
host response
Hypoxemia
indicated
infected with SARS-CoV-2
Infection
inflammatory mediator
intranasal
lack
lung
Lung injury
molecular
molecular mechanism
pulmonary permeability
RNA sequencing
SARS-CoV-2
SARS-COV-2 infection
severe COVID-19
significant difference
syndrome
Syrian Golden hamsters
systemic illness
upregulation
Viral pneumonia
virus
[DOI] 10.1016/j.trsl.2021.10.007 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.trsl.2021.10.007 PMC 바로가기 [Article Type] Article