While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long-Hauler’s Syndrome or PACS (postacute sequelae of SARS-CoV-2 infection). There is little known about risk factors or predictors of susceptibility for Long-Hauler’s Syndrome, but older adults are at greater risk for severe outcomes and mortality from COVID-19. The pillars of aging (including cellular senescence, telomere dysfunction, impaired proteostasis, mitochondrial dysfunction, deregulated nutrient sensing, genomic instability, progenitor cell exhaustion, altered intercellular communication, and epigenetic alterations) that contribute to age-related dysfunction and chronic diseases (the “Geroscience Hypothesis”) may interfere with defenses against viral infection and consequences of these infections. Heightening of the low-grade inflammation that is associated with aging may generate an exaggerated response to an acute COVID-19 infection. Innate immune system dysfunction that leads to decreased senescent cell removal and/or increased senescent cell formation could contribute to accumulation of senescent cells with both aging and viral infections. These processes may contribute to increased risk for long-term COVID-19 sequelae in older or chronically ill patients. Hence, senolytics and other geroscience interventions that may prolong healthspan and alleviate chronic diseases and multimorbidity linked to fundamental aging processes might be an option for delaying, preventing, or alleviating Long-Hauler’s Syndrome.
【저자키워드】 severe acute respiratory syndrome coronavirus 2, Coronavirus disease 2019, intensive care unit, Severe acute respiratory syndrome, Middle East respiratory syndrome Coronavirus, skilled nursing facility, reactive oxygen species, Translational Geroscience Network, facility for geroscience analysis, Long-term care facility, COVID-19coronavirus disease 2019, SARS-CoV-2severe acute respiratory syndrome coronavirus 2, WHOWorld Health Organization, World Health Organization, ICUIntensive Care Unit, SARSSevere Acute Respiratory Syndrome, multiple chronic conditions, MERS-CoVmiddle east respiratory syndrome coronavirus, AMPKAMP-activated protein kinase, AMP-activated protein kinase, COVID-FISA phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes, A phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes, CRcaloric restriction, caloric restriction, FGAFacility for Geroscience Analysis, IFintermittent fasting, intermittent fasting, LTCFlong-term care facility, MCCmultiple chronic conditions, mTORmammalian target of rapamycin, mammalian target of rapamycin, NAD+nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide, NMNnicotinamide mononucleotide, nicotinamide mononucleotide, NRnicotinamide riboside, nicotinamide riboside, PACSpostacute sequalae of SARS-CoV-2 infection, postacute sequalae of SARS-CoV-2 infection, PAMPspathogen-associated molecular profile factors, pathogen-associated molecular profile factors, ROSreactive oxygen species, SARS-CoV-1severe acute respiratory syndrome coronavirus 1, severe acute respiratory syndrome coronavirus 1, SASPsenescence-associated secretory phenotype, senescence-associated secretory phenotype, SNFskilled nursing facility, TGNtranslational geroscience network, 【초록키워드】 COVID-19, viral infection, Mortality, SARS-COV-2 infection, susceptibility, Infection, risk, Intervention, outcome, risk factor, viral infections, chronic disease, infections, Patient, predictor, mitochondrial dysfunction, genomic, Epigenetic, cellular senescence, low-grade inflammation, Innate, Multimorbidity, COVID-19 symptom, Immune system dysfunction, dysfunction, Older, increased risk, acute COVID-19, Defense, Intercellular communication, while, Cell, consequence, greater, indicated, generate, contribute, interfere, senescent, alleviate, deregulated, alterations, cell removal, ill patients, senescent cell, 【제목키워드】 COVID-19, Health, role, consequence,