Drug repurposing against SARS-CoV-2 receptor binding domain using ensemble-based virtual screening and molecular dynamics simulationsResearch article Published on 2021-08-012022-10-05 Journal: Computers in biology and medicine [Category] SARS, 신약개발, [키워드] ACE2 proteins ACE2-RBD acute respiratory syndrome approach binding binding domain binding site caused Clustering analysis conformation conformational Conformational ensemble conformations Coronavirus-2 COVID-19 death docking scores drug drug design Drug repurposing drugs exhibited FDA approved drug help human ACE2 identify inhibiting Interaction investigated MD simulation MD simulations molecular Molecular dynamics simulation plasticity predicted RBD Receptor binding domain Respiratory disease responsible SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 receptor significantly Spike protein stability the RBD the SARS-CoV-2 Virtual screening virus infection were used worldwide pandemic [DOI] 10.1016/j.compbiomed.2021.104634 [Article Type] Research article
The first detection of SARS-CoV-2 RNA in the wastewater of Tehran, Iran이란 테헤란 폐수서 SARS-CoV-2 RNA 최초 검출Article Published on 2021-08-012022-09-11 Journal: Environmental science and pollution research inter [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition avian coronavirus Chain Reaction circulation Concentration coronavirus COVID-19 COVID-19 case death detect Ecology Effluent Health IBV implication Infectious Bronchitis Virus influent Influent water investigated Iran Local N genes ORF1 ORF1ab plant polymerase chain polymerase chain reaction quantitative polymerase chain reaction reported resulting reverse transcription RT-qPCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus Spread Tehran treated Treatment was increased was tested wastewater water WHO worldwide pandemic [DOI] 10.1007/s11356-021-13393-9 PMC 바로가기 [Article Type] Article
Case series of coronavirus (SARS-CoV-2) in a military recruit school: clinical, sanitary and logistical implications군 신병 학교의 코로나바이러스(SARS-CoV-2) 사례 시리즈: 임상, 위생 및 물류 영향Article Published on 2021-08-012022-09-12 Journal: BMJ military health [Category] MERS, SARS, 진단, [키워드] 48 hours Asymptomatic asymptomatic patient carriers case sery caused China close contact Complete coronavirus Course covert COVID-19 COVID-19 case defined described Diagnosis Epidemiology force healthy IgM and IgG implication infected patient Infection infection control initial Isolation Mild nasopharyngeal swabs New coronavirus nine Patient patients positive positive PCR public health quarantine recruit respiratory responsible retrospective review SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 PCR Spread Switzerland Symptom symptom resolution symptomatic tested Viral transmission was performed worldwide pandemic [DOI] 10.1136/bmjmilitary-2020-001482 PMC 바로가기 [Article Type] Article
A Sanger-based approach for scaling up screening of SARS-CoV-2 variants of interest and concern관심 및 우려의 SARS-CoV-2 변종에 대한 스크리닝을 확대하기 위한 Sanger 기반 접근 방식Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, [키워드] A570D approach B.1.1 characteristic characterized COVID-19 pandemic COVID-19 sample E484K evaluated Frame genetic material identify Laboratory limitation Lineage lineages molecular molecular surveillance N501Y new SARS-CoV-2 P.1 P.2 Patient PCR protocol protocols public health RBD reagent Sanger sequencing SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 surveillance SARS-CoV-2 variant SARS-CoV-2 variants of concern Spread Surveillance Time frame variants of concern virus VoC VOCs WGS whole-genome sequencing worldwide pandemic [DOI] 10.1016/j.meegid.2021.104910 PMC 바로가기 [Article Type] Article
COVID-19 and Aspiration Pneumonia: Similar Pulmonary Findings with Different Diagnoses—a Pitfall in [18F]FDG PET/CTCovid-19 Published on 2021-07-292022-10-29 Journal: Sn Comprehensive Clinical Medicine [Category] COVID-19, [키워드] [18F]FDG PET/CT Ab ingestis acute respiratory syndrome affected aspiration aspiration pneumonia Case report coronavirus cough COVID-19 described differential diagnose fatigue Fever finding ground-glass opacity myalgia other disease other diseases pandemic PET/CT plethora Pneumonia pulmonary radiological recognize SARS-CoV-2 SARS-COV-2 infection Symptom treated urgency worldwide pandemic [DOI] 10.1007/s42399-021-01030-y PMC 바로가기 [Article Type] Covid-19
Outpatient Management of COVID-19 Disease: A Holistic Patient-Centered Proposal Based on the Greek ExperienceReview Published on 2021-07-232022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] acute respiratory syndrome affected caused Community coronavirus coronavirus disease country COVID-19 COVID-19 pandemic COVID-19 patients criteria deaths experience Greek Guidance hospital hospital discharge Hospitalization Infectious disease Isolation management novel Outpatient Patient patients with COVID-19 preventive measures proposal quarantine released resulting risk stratification SARS-CoV-2 second wave severe disease severity Society the disease with mild disease worldwide pandemic [DOI] 10.3390/jpm11080709 PMC 바로가기 [Article Type] Review
Evaluation and Comparison of Serological Methods for COVID-19 DiagnosisMolecular Biosciences Published on 2021-07-232022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] antibody chemiluminescence immunoassay CLIA Clinical diagnosis COVID-19 COVID-19 diagnosis diagnostic early diagnosis Effect Efficiency ELISA enzyme-linked immunosorbent global public health golden standard healthy help IMPROVE include increasingly lateral flow immunoassay LFIA Nucleic acid detection nucleic acid test Patient problem respiratory tract SARS-CoV-2 sensitivity serological serological test Serological testing spread of COVID-19 viral nucleic acid virus detection worldwide pandemic [DOI] 10.3389/fmolb.2021.682405 PMC 바로가기 [Article Type] Molecular Biosciences
Dynamic Characteristic Analysis of Antibodies in Patients With COVID-19: A 13-Month StudyCOVID-19 환자에서 항체의 동적 특성 분석: 13개월 연구Immunology Published on 2021-07-202022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibodies antibody Antibody Response characteristic collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 described detective domain dynamic early stage effective Extracellular Hospitalized IgA level IgA levels IgM Immunity Immunoglobulin immunoreaction Infection Neutralizing activity Neutralizing antibodies nucleocapsid protein observation offered onset of symptom Patient POS Postinfectious quantified reaction Receptor binding domain Receptor-binding domain remained respiratory SARS-CoV-2 SARS-CoV-2 spike Screen serum sample severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein target targets vaccination worldwide pandemic [DOI] 10.3389/fimmu.2021.708184 PMC 바로가기 [Article Type] Immunology
Potentials of Antitussive Traditional Persian Functional Foods for COVID-19 Therapy †Pharmacology Published on 2021-07-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activities acute respiratory syndrome age Anti-inflammation Anti-inflammatory antioxidant antitussive Antiviral applied candidate Combination Compound Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 therapy Direct Effect FDA-approved drug food functional food Functional foods global pandemic Google Scholar hospitalized patient immunomodulatory natural Older pharmacological pharmacological mechanism phytochemical positive Potential potential mechanism prevention of COVID-19 protective effect Psychological PubMed Central resulting Safe SARS-COV-2 infection School Science searched Seven Therapeutic strategies Traditional traditional Persian medicine Treatment was performed worldwide pandemic [DOI] 10.3389/fphar.2021.624006 PMC 바로가기 [Article Type] Pharmacology
Emergence of a young case infected with avian influenza A (H5N6) in Anhui Province, East China during the COVID‐19 pandemicCase Reports Published on 2021-07-142022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 변종, 조류인플루엔자, 치료기술, [키워드] addition analyzed caused Characteristics China city clade Clinical characteristics collected coronavirus disease COVID‐19 COVID‐19 East emergence epidemiological Epidemiology Evolution feature Genetic Genome genomic H5N1 H5N6 H7N9 highly pathogenic Influenza influenza A Influenza virus investigated knowledge Novel coronavirus outbreak pandemic pathogen Patient Pneumonia polymerase chain positive rate Receptor binding Seasonal influenza subtype Surveillance virus viruses worldwide pandemic zoonotic infections [DOI] 10.1002/jmv.27179 PMC 바로가기 [Article Type] Case Reports