Rapid Genomic Characterization of SARS-CoV-2 by Direct Amplicon-Based Sequencing Through Comparison of MinION and Illumina iSeq100 TM SystemMicrobiology Published on 2020-09-252022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] amplicon-based sequencing approach characterization Chinese clinical sample consensus genome COVID-19 Direct Genome sequencing Health help human diseases Illumina increasingly involved iSeq100TM system Laboratory MERS Middle East MinION next-generation sequencer pathogen Pneumonia public health measures Rapid real-time genome sequencing respiratory SARS-CoV-2 System Threats viral outbreak viral sequence Wuhan [DOI] 10.3389/fmicb.2020.571328 PMC 바로가기 [Article Type] Microbiology
MeCas12a, a Highly Sensitive and Specific System for COVID‐19 DetectionFull Paper Published on 2020-09-232022-10-28 Journal: Advanced Science [Category] COVID-19, [키워드] acute respiratory syndrome cleavage clinical sample clinical samples coronavirus COVID‐19 COVID‐19 CRISPR/Cas12a CRISPR‐based detection described detect detection Detection sensitivity Diagnosis Diseases DNA FIVE Infectious disease limit of detection manganese MERS Middle East nucleic acid reporter respiratory syndrome coronavirus RNA RNAs SARS‐CoV‐2 SARS‐CoV‐2 sensitive single nucleotide Single nucleotide polymorphism SNPs Specific specificity System [DOI] 10.1002/advs.202001300 PMC 바로가기 [Article Type] Full Paper
COVID-19 and Respiratory System Disorders Current Knowledge, Future Clinical and Translational Research Questions10008 Published on 2020-09-222022-10-28 Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] COVID-19, Fulltext, SARS, [키워드] Abstract acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome clinical coronavirus disease Coronavirus-2 COVID-19 current Diaphragm disorder Effect Future highlight human pathogen Infection lung parenchymal Research respiratory Respiratory disease Respiratory failure Respiratory system severe COVID-19 syndrome System the disease Thromboembolism translation Vascular [DOI] 10.1161/ATVBAHA.120.314515 PMC 바로가기 [Article Type] 10008
A machine learning algorithm to increase COVID-19 inpatient diagnostic capacityCOVID-19 입원 환자 진단 능력을 높이는 기계 학습 알고리즘Research Article Published on 2020-09-222022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval Algorithm an area bottleneck Chain Reaction collected data Combination COVID-19 develop diagnose diagnostic diagnostic classification emergency room evaluate Final hospital laboratory feature Los Angeles machine learning model Metrics operator PCR testing PCR-based testing polymerase chain polymerase chain reaction receiving SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2 PCR testing sensitivity Seven specificity System tested [DOI] 10.1371/journal.pone.0239474 PMC 바로가기 [Article Type] Research Article
Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin SystemCell and Developmental Biology Published on 2020-09-162022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE ACE2 activate addition Ang II Ang-(1-7) angiotensin Angiotensin II anti-inflammatory effect AT1 AT1 receptor binding carried cascade cell entry cellular receptor cleavage cleave clinical trial components consequence convert Coronaviridae family coronavirus Course COVID-19 database domain downregulation effort enzyme facilitate human cells insight Interaction Intervention intracellular signaling involved LILACS Lung injury mechanism membrane fusion membrane-bound molecular interaction pandemic pathogen Pathogenesis pathogenesis of COVID-19 pathway Pathways Perspective pro-inflammatory promote RAS RBD receptor Renin renin angiotensin system Research S2 domain SARS-CoV-2 SARS-CoV-2 cell SciELO Scientific community Signaling spike glycoprotein subunits System therapeutic target TMPRSS2 transmembrane treating COVID-19 Treatment vasoconstriction virus [DOI] 10.3389/fcell.2020.559841 PMC 바로가기 [Article Type] Cell and Developmental Biology
In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression AnalysisPharmacology Published on 2020-09-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ADORA2A ADRB2 alleviation Analysis Anti-inflammatory antioxidant approach Astragaloside IV Bioinformatic Bioinformatics analysis caused chemokine contribute COVID-19 COVID-19 patients cytokine cytokine storms dataset DEGs differentially expressed gene down-regulated genes drug candidate GBP1 Gene Expression Omnibus Genes GEO GO term GSE147507 hyper-inflammation hyperinflammation IL1B IL6 Inflammation KEGG KEGG pathway Kyoto MLNR MMP13 network network pharmacological network pharmacology NFKBIA NLRP3 Ontology overlap overlapping pathway pathway enrichment performed pharmacological mechanism Pharmacology Potential prediction PTAFR Result SARS-CoV-2 screened System target TNF Treatment TRIM21 up-regulated [DOI] 10.3389/fphar.2020.556984 PMC 바로가기 [Article Type] Pharmacology
Patient characteristics and admitting vital signs associated with coronavirus disease 2019 (COVID-19)–related mortality among patients admitted with noncritical illness심각하지 않은 질병으로 입원한 환자 중 코로나바이러스 질병 2019(COVID-19) 관련 사망률과 관련된 환자 특성 및 인정하는 활력 징후Original Article Published on 2020-09-152022-09-12 Journal: Infection Control and Hospital Epidemiology [Category] MERS, 진단, [키워드] 95% CI Admission Admitted Patient age Analysis Care Characteristics characterized collected Community Comorbidities Comorbidity coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical care Critically ill Decreased demographic characteristics Determination determine diabete diabetes discharge epidemiologists Factor help hospital Logistic regression mechanical ventilation Mortality MOST oxygen oxygen saturation Patient patient age patient data patients positive recorded Retrospective analysis risk factor Risk factors routine care System The United States United States vital sign vital signs [DOI] 10.1017/ice.2020.461 PMC 바로가기 [Article Type] Original Article
Systems Pharmacology and Verification of ShenFuHuang Formula in Zebrafish Model Reveal Multi-Scale Treatment Strategy for Septic Syndrome in COVID-19Pharmacology Published on 2020-09-152022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] affected AKR1B10 Analysis Bacterial Chinese Clinical treatment coagulation disorder complementary Compound coronavirus disease COVID-19 COVID-19 patient deficiency develop disease Effect ENhance ESR1 Evidence exhibited expression Formula immune immune dysfunction immune gene IMPROVE in viral Inflammatory inhibited investigated involved Macrophage MAPK MAPK14 metabolic disease Model network neutrophil outbreak phagocytosis pharmacological Pharmacology PPARG provided PTGS2 receptor reducing Result Sepsis septic signaling pathway significantly Strategy syndrome System Systems pharmacology target targets therapy Thrombus Toll-like receptors Traditional Chinese medicine treating COVID-19 patient Treatment VEGF verification viral infection Wuhan zebrafish [DOI] 10.3389/fphar.2020.584057 PMC 바로가기 [Article Type] Pharmacology
COD19 and COD20: An Italian Experience of Active Home Surveillance in COVID-19 PatientsArticle Published on 2020-09-142022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Active surveillance acute respiratory syndrome center clinical condition Clinical data COD19 COD20 collected coronavirus coronavirus disease COVID-19 Critical Epidemic experience flexible Health home home surveillance Hospital admission intensive care intrinsically Italian Italy many case numbers of patient operation pandemic Patient platform recognizing required SARS-CoV-2 Satisfaction service System telemedicine service Web [DOI] 10.3390/ijerph17186699 PMC 바로가기 [Article Type] Article
Correlation of COVID-19 Pandemic with Healthcare System Response and Prevention Measures in Saudi ArabiaArticle Published on 2020-09-132022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] age Annual catastrophic Community coronavirus country COVID-19 death rate develop disease distribution environmental measures evaluate facilitate Government health system healthcare infected cases Infection International Isolation measure Ministry of Health organizational measures pandemic Population Prevent prevention preventive measure PROTECT protection protocol provide public health reduced reducing report response SARS-CoV-2 Saudi Arabia screening test seeking Spread spread of COVID-19 System Transmission Treatment were measured widespread [DOI] 10.3390/ijerph17186666 PMC 바로가기 [Article Type] Article