Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug RepositioningArticle Published on 2020-09-262022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Analysis approval approved candidate Candidates cellular Compound COVID-19 COVID-19 pandemic death drug drug repositioning drug target effort eight Host immune response infected cell involved knowledge mechanisms network network biology predict predicted Protein PVR repositioning rising SARS-CoV-2 SARS-COV-2 infection SCARB1 Stress suggested the SARS-CoV-2 Therapies Topology translation Transport Virus-host interactions [DOI] 10.3390/v12101087 PMC 바로가기 [Article Type] Article
Is It High Time to Increase Elite Soccer Substitutions Permanently?Article Published on 2020-09-252022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] change collected comparison coronavirus coronavirus disease COVID-19 determine dimension eight Elite evaluate example fatigue FIVE Football incidence increase Injury mitigate occur pandemic performed physical physical demand Prophylaxis rule Rules Simulation Sports Medicine Substitution substitutions time understanding [DOI] 10.3390/ijerph17197008 PMC 바로가기 [Article Type] Article
A study on COVID-19 transmission dynamics: stability analysis of SEIR model with Hopf bifurcation for effect of time delayResearch Published on 2020-09-242022-10-28 Journal: Advances in Difference Equations [Category] COVID-19, [키워드] 34D20 34E05 34K50 Analysis asymptotic calculated coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 transmission Covid19 Indian pandemic Effect eight experiment greater Hopf bifurcation immune response initial less outbreak pandemic parameter Reproduction number reveal SEIR sensitivity Sensitivity parameters Seven stability transmission rate [DOI] 10.1186/s13662-020-02958-6 PMC 바로가기 [Article Type] Research
Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers지속적인 비인두 운반체에서 과산화수소에 의한 SARS-CoV-2의 단기 억제Short Communication Published on 2020-09-242022-09-10 Journal: Journal of medical virology [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assistance baseline burning sensation carrier convalescent coronavirus coronavirus disease Coronavirus disease 2019 Course COVID‐19 COVID‐19 degrade effective eight excluded hydrogen hydrogen peroxide hypertonic solution Incubation period investigated measure median time mucosal surfaces nasopharingeal nasopharyngeal negative swab one patient Patient persistent physician positive prevention prevention service Prevention Service) PROTECT quarantine respiratory SARS‐CoV‐2 SARS‐CoV‐2 service severe acute respiratory syndrome Coronavirus Side effect subject subjects suppressed Swab swabs symptom onset tested threshold Tolerability upper respiratory Viral viral shedding virus [DOI] 10.1002/jmv.26485 PMC 바로가기 [Article Type] Short Communication
The Recommended and Excessive Preventive Behaviors during the COVID-19 Pandemic: A Community-Based Online Survey in ChinaArticle Published on 2020-09-232022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Analysis Behavior belief Chi-square China collected Community component COVID-19 COVID-19 outbreak eight engage extreme Factor global public health group Health Belief Model Hierarchical information knowledge less Logistic regression analysis Mantel–Haenszel mental health Model participant Perceived Perceived benefits Prevent Preventive behaviors propensity score matching Psychological psychological condition questionnaire Support survey susceptibility Symptom [DOI] 10.3390/ijerph17196953 PMC 바로가기 [Article Type] Article
The Relationship of COVID-19 Severity with Cardiovascular Disease and Its Traditional Risk Factors: A Systematic Review and Meta-AnalysisOriginal Research Published on 2020-09-222022-10-31 Journal: Global Heart [Category] COVID-19, [키워드] acute respiratory distress adjusted Admission age age and sex analyses cardiovascular cardiovascular disease conducted COVID-19 COVID-19 patient CVD death defined diabete diabetes eight eligible English estimate Factor Factors hypertension inclusion criteria independent inhibitor intensive care Male sex mechanical ventilation Meta-analysis Meta-regression analyses meta-regression analysis multivariable analysis performed predict Random-effects models relationship renin-angiotensin system reported review risk risk factor Risk factors searched severe cases severe coronavirus disease severe COVID-19 suggested syndrome systematic review Traditional [DOI] 10.5334/gh.814 PMC 바로가기 [Article Type] Original Research
Computational Evaluation of the Inhibition Efficacies of HIV Antivirals on SARS-CoV-2 (COVID-19) Protease and Identification of 3D Pharmacophore and Hit CompoundsResearch Article Published on 2020-09-212022-10-28 Journal: Advances in Pharmacological and Pharmaceutical Sciences [Category] COVID-19, [키워드] acute respiratory syndrome analysed anti-HIV drug antiviral drugs AutoDock binding affinity binding score carried classification Compound compounds Computational study coronavirus coronavirus disease COVID-19 derivation Discovery Studio docked docking study drug Efficacy eight evaluate evaluated Health practitioner HIV HIV treatment hydrophilic identification identify In silico methods in vivo inhibit inhibition Interaction majority medication molecular Novel coronavirus parameters Patient performed pharmaceutical pharmacophore protease Protease inhibitor Protein Data Bank reported researcher Ritonavir SARS-CoV-2 SARS-CoV-2 protease spread of COVID-19 Structure the SARS-CoV-2 these compound these compounds treat Vaccine was obtained web server X-ray crystallographic structure [DOI] 10.1155/2020/8818008 PMC 바로가기 [Article Type] Research Article
Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune PerspectiveImmunology Published on 2020-09-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 protein ACE2 proteins adhere animal model antibodies antibody binding-affinity block blocking caused classical Combination comparison COVID-19 Critical crystal structure develop effective eight epithelial epithelial cells epitope felines Host Human human ACE2 IgA dimer Infection Interaction interaction-synapse interactions interface interfere intestine Multiple Neutralizing antibodies neutralizing antibody pandemic Protein protein-protein interaction Proteins SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 transmission significant difference single antibody spike therapeutic therapy treating COVID-19 Vaccine virus X-ray [DOI] 10.3389/fimmu.2020.570018 PMC 바로가기 [Article Type] Immunology
Clinical impact of COVID-19 in a single-center cohort of a prospective study in cancer patients receiving immunotherapyPreliminary Communication Published on 2020-09-162022-10-31 Journal: Immunotherapy [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Anti-PD-1 cancer patient Cancer patients cardiovascular disease clinical Cohort coronavirus Course COVID-19 diagnosis of COVID-19 eight enrolled Evaluating event feature high risk Immune checkpoint inhibitors Immunotherapy incidence Infection Influenza influenza vaccine interstitial pneumonia males multicenter Patient patients patients died Pharyngeal swab positive Prospective Study receiving reported Respiratory failure SARS-CoV-2 SARS-CoV2 single-center the patient treated [DOI] 10.2217/imt-2020-0211 PMC 바로가기 [Article Type] Preliminary Communication
Covid‐19 in patients with hematological and solid cancers at a Comprehensive Cancer Center in GermanyOriginal Research Published on 2020-09-152022-10-31 Journal: Cancer Medicine [Category] COVID-19, SARS, [키워드] association Cancer cancer diagnosis Cancer management center Clinical characteristics Clinical improvement Cohort cohort of patient cohort study Comprehensive Diagnosis died eight Epidemiology epidemiology and prevention event events Fatality rate Germany hematological hematological cancer Hematological malignancy Hospitalization Hospitalized hotspot IL‐6 influences on investigated Major malignancy Mortality multivariate Cox regression observation period observé Occurrence outcome Patient performed Presence Probability Result retrospective severe disease course significantly single center solid cancer solid tumor survival university viral infection Viral pneumonia [DOI] 10.1002/cam4.3460 PMC 바로가기 [Article Type] Original Research