Early combination therapy with immunoglobulin and steroids is associated with shorter ICU length of stay in Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19: A retrospective cohort analysis from 28 U.S. Hospitals면역글로불린과 스테로이드를 사용한 조기 병용 요법은 COVID-19와 관련된 소아 다기관 염증 증후군(MIS-C)의 ICU 체류 기간 단축과 관련이 있습니다. 28개 미국 병원의 후향적 코호트 분석Article Published on 2022-07-012022-09-12 Journal: Pharmacotherapy [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adjustment Admission Analysis analyzed benefit children with MIS-C Combination combination therapy confidence interval confounder confounders Corticosteroids COVID-19 Day Fever hospital Hospitalization hospitalized patient ICU illness Immunoglobulin Impact include inflammatory mediator initiated intensive care Intravenous immunoglobulin IQR IVIG LOS median age Medicine MIS-C Mortality multivariable organ dysfunction outcomes Patient random intercept registry required respiratory retrospective cohort Retrospective study secondary outcome shown significant decrease significant difference Society steroid Steroids study population The United States therapeutic option therapy total patients Universal [DOI] 10.1002/phar.2709 PMC 바로가기 [Article Type] Article
Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trialRandomized Controlled Trial Published on 2022-07-012022-10-04 Journal: Intensive care medicine [Category] COVID19(2023년), SARS, 임상, [키워드] active smoker Acute respiratory failure Administered Adverse affected artificial assessment assigned Care conducted confidence interval coronavirus disease COVID-19 Critically ill patient daily dose days alive dose double-blind Efficacy and safety event France function intensive care unit intensive care units Invasive mechanical ventilation IQR mechanical ventilation median men Mortality multicentre Nicotine Nicotinic receptor not differ Odds ratio on mechanical ventilation Organ failure Patient Placebo placebo-controlled placebo-controlled trial Pneumonia Primary outcome Randomized randomized trial Randomly receive receiving reduce renal replacement therapy secondary outcome Severe COVID-19 pneumonia significantly smoker stratified symptomatic patient the median the placebo group Trial two group two groups vasopressor support Ventilation ventilator-free day with COVID-19 [DOI] 10.1007/s00134-022-06721-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Outcome after single dose of ChAdOx1 vaccine against SARS-CoV-2 infection at 16 weeks post-vaccination among healthy adults in Saudi Arabia사우디아라비아의 건강한 성인을 대상으로 백신 접종 16주 후 SARS-CoV-2 감염에 대한 ChAdOx1 백신 1회 접종 후 결과Article Published on 2022-07-012022-09-11 Journal: Annals of Saudi medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age anti-Nucleocapsid IgG anti-Spike IgG anti-spike IgG level antibody Antibody Response blood sample Blood samples ChAdOx1 ChAdOx1 vaccine Chain Reaction conflict conflict of interest coronavirus cross-sectional study demonstrated detectable dose female had no healthy hospital immunogenicity individual Infection intensive care IQR median Mild occurred outcome participant Participants PCR-confirmed polymerase chain polymerase chain reaction recruited Sample Sample size SARS CoV SARS CoV-2 SARS CoV-2 infection SARS-COV-2 infection Saudi Arabia sensitivity severe acute respiratory syndrome Coronavirus significantly single dose single-center small sample size subject subsequent vaccination [DOI] 10.5144/0256-4947.2022.223 PMC 바로가기 [Article Type] Article
Antibody and cellular immune responses following dual COVID-19 vaccination within infection-naive residents of long-term care facilities: an observational cohort studyObservational Study Published on 2022-07-012022-10-05 Journal: The Lancet. Healthy longevity [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] age antibody Antibody Response binding blood sample booster vaccination Care CD4 T-cell Cellular immune response cellular response Clinical outcome Comorbidity COVID-19 COVID-19 vaccination COVID-19 vaccine CXCL10 production Department EDTA eligible exclusion criteria Factors for inclusion frailty functional groups humoral IFN-γ IL-2 immune dysregulation immune protection immune response Impaired individual Infection IQR median median age neutralisation Observational cohort study Older participant Post-vaccine quantified response risk factor Sample SARS-CoV-2 SARS-COV-2 infection second vaccination SFU significantly staff stratified T-cell Response TNFα vaccination vaccine doses variant spike was reduced were assessed [DOI] 10.1016/S2666-7568(22)00118-0 PMC 바로가기 [Article Type] Observational Study
Variant of Concern-Matched COVID-19 Convalescent Plasma Usage in Seronegative Hospitalized Patients혈청 음성 입원 환자에서 우려 일치 COVID-19 회복기 혈장 사용의 변형Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 28-day mortality advanced disease Adverse reaction Adverse reactions affecting age anti-spike monoclonal antibodies anti-spike monoclonal antibody Anti-viral therapy Blood donors CCP collected convalescent convalescent plasma COVID-19 COVID-19 convalescent plasma Delta Efficacy hospital Hospitalized hospitalized COVID-19 patient hospitalized patient Immunocompromised Immunocompromised patient Immunocompromised patients infused IQR Italian mAb mAbs median age mortality rate NAbs Neutralizing antibodies neutralizing antibody omicron outcome patients protective immune response Randomized controlled trial recipient reported rescued SARS-CoV-2 seronegative severe COVID-19 Support Two patient two patients Usage variants variants of concern VoC VOCs were recorded [DOI] 10.3390/v14071443 PMC 바로가기 [Article Type] Article
T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article
SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study덴마크의 노숙자와 보호소 근로자 사이의 SARS-CoV-2 항체 유병률: 전국 횡단 연구Article Published on 2022-06-272022-09-12 Journal: BMC Public Health [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95%CI acute respiratory syndrome antibody blood donor conducted coronavirus cross-sectional Denmark determine eligible ELISA assay female higher risk Infection IQR median age National participant point-of-care Prevalence provided questionnaire recruited recruitment reported risk Safe SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 vaccination seronegative participant Sex significantly higher significantly increased Symptom tested total Ig Vaccine [DOI] 10.1186/s12889-022-13642-7 PMC 바로가기 [Article Type] Article
Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center경증 COVID-19의 조기 식별을 위한 현장 진료 폐 초음파 검사: 스위스 선별 센터의 외래 환자 집단Observational Study Published on 2022-06-242022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] addition blinded clinical feature Clinical features Clinical finding Clinical findings cough COVID-19 COVID-19 negative criteria detect diagnose diagnostic diagnostic radiology Dyspnoea evaluate Features healthcare worker healthy independent Infectious diseases investigators IQR lung Lung pathology Mild multivariate logistic regression Nasopharyngeal swab nasopharyngeal swabs Outpatient outpatients pathologic Patient patients PCR point-of-care positive Predictive Predictive value presenting prospective cohort prospective observational cohort quarantine recorded reduce SARS-CoV-2 SARS-COV-2 infection secondary outcome sensitivity significantly more symptom onset Transmission Ultrasonography university with COVID-19 zone [DOI] 10.1136/bmjopen-2021-060181 PMC 바로가기 [Article Type] Observational Study
COVID-19 outbreak in vaccinated patients from a haemodialysis unit: antibody titres as a marker of protection from infection혈액 투석실에서 예방 접종을 받은 환자의 COVID-19 발생: 감염으로부터 보호하는 지표로서의 항체 역가Article Published on 2022-06-232022-09-11 Journal: Nephrology, dialysis, transplantation : official p [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Alpha variant anti-S anti-S IgG Anti-spike Antibody titre BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 vaccine Casirivimab cause Clinical data Combination confidence interval coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection COVID-19 outbreak dialysis dialysis room Haemodialysis humoral Humoral response identify IgG Imdevimab immune correlate immune correlates Immunoglobulin Immunoglobulin G Immunosuppression increased risk Infection interquartile range IQR marker monoclonal antibodies monoclonal antibody mRNA vaccination multivariable analysis neutralization Odds ratio outbreak Patient patients prevented recorded reduced respiratory SARS-CoV-2 SARS-COV-2 infection serological response severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 severe disease the patient titre treated uninfected vaccination Vaccines variant were infected with COVID-19 [DOI] 10.1093/ndt/gfac016 PMC 바로가기 [Article Type] Article
Serological Response to BNT162b2 Anti-SARS-CoV-2 Vaccination in Patients with Inflammatory Rheumatic Diseases: Results From the RHEUVAX Cohort염증성 류마티스 질환 환자에서 BNT162b2 Anti-SARS-CoV-2 백신 접종에 대한 혈청학적 반응: RHEUVAX 코호트의 결과Article Published on 2022-06-172022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] abatacept age Analysis anti-SARS-CoV-2 vaccine antibody Antibody titer Antibody titers Arthritis Autoimmunity autoinflammatory disease BNT162b2 CCS Community connective tissue connective tissue disease connective tissue disease (CTD) Control Corticosteroid COVID-19 COVID-19 epidemic CTD CTRL disease dose Effective vaccines eight Factor Health profession higher risk identify immune immunological Immunosuppressive medication impair inhibitor IQR jak inhibitors Logistic regression Lower median MMF mycophenolate Necrosis of BNT162b2 Patient patients performed Protein protocol recruited response response to vaccination Result rheumatic and muscoluskeletal disease rheumatic disease rheumatoid arthritis rituximab Sample seroconversion rate severe COVID-19 Specific spike Treatment vaccination vaccine dose Vaccines Vasculitis [DOI] 10.3389/fimmu.2022.901055 PMC 바로가기 [Article Type] Article