Negative Nasopharyngeal SARS-CoV-2 PCR Conversion in Response to Different Therapeutic InterventionsInfectious Disease Published on 2022-01-202022-10-31 Journal: Cureus [Category] COVID-19, [키워드] accelerate antimalarial antiviral drug association Care Chloroquine clearance Combination conversion Course COVID-19 diagnosis of COVID-19 FIVE HCQ hospital Hydroxychloroquine Infection prevention Infectious disease interquartile range Intervention management median time medication nasopharyngeal negative Negative PCR Novel coronavirus Patient PCR polymerase chain prescribing response Result retrospective cohort study SARS-CoV-2 SARS-CoV-2 PCR Saudi Arabia secondary endpoint shown statistically significant difference supportive care the disease the median therapeutic interventions [DOI] 10.7759/cureus.21442 PMC 바로가기 [Article Type] Infectious Disease
The Transient IFN Response and the Delay of Adaptive Immunity Feature the Severity of COVID-19Immunology Published on 2022-01-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accelerate adaptive Biomarker category Clinical outcome COVID-19 COVID-19 patient dataset Delay delayed adaptive immunity determine early immune feature early stage feature heterogeneous IFN IFN response immune immune response Immunity indicated innate immune response monocyte outcomes Peripheral blood progression proportion provided response returned reveal scRNA-seq severe COVID-19 severe disease Single-cell RNA sequencing the disease Transient viral infection [DOI] 10.3389/fimmu.2021.816745 PMC 바로가기 [Article Type] Immunology
Global COVID-19 Vaccine Acceptance: A Systematic Review of Associated Social and Behavioral FactorsReview Published on 2022-01-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] “COVID-19 accelerate Analysis analyzed ANOVA Associated factors China country COVID-19 COVID-19 pandemic COVID-19 vaccine Direct Ecuador effort eligible eliminating Factor global variations Government HCW HCWs healthcare worker highest implication Indonesia inefficient Italy lowest Malaysia media Nurse pandemic peer-reviewed populations review Science searched statistically significant Strategy systematic review Vaccine Vaccine acceptance Vaccine hesitancy Variation Web of Science [DOI] 10.3390/vaccines10010110 PMC 바로가기 [Article Type] Review
Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple TargetsArticle Published on 2022-01-122022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] 3C-like protease (3CLpro/Mpro) 3CL pro accelerate acute respiratory syndrome addition anti-SARS-CoV-2 antiviral potency approved assays bioinformatics Compound coronavirus coronavirus disease COVID-19 docking simulation domain drug Drug screening enzyme activity evaluated feasible food identification infections inhibitory inhibitory effect Multiple other diseases Papain-like protease papain-like protease (PLpro) protease RBD reduction repurposing SARS-CoV-2 serine 2 severe acute respiratory syndrome coronavirus 2 Tamoxifen target therapeutic potential these compound TMPRSS2 transmembrane transmembrane protease serine 2 (TMPRSS2) Treatment Vaccines [DOI] 10.3390/pharmaceutics14010176 PMC 바로가기 [Article Type] Article
BioSamples database: FAIRer samples metadata to accelerate research data managementBioSamples 데이터베이스: FAIRer는 메타데이터를 샘플링하여 연구 데이터 관리를 가속화합니다.AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] 유전자 메커니즘, [키워드] accelerate Alliance benefit Community complex connection content contribute COVID-19 research data management Data quality database described feature Genomics genotypic heterogeneous highlight IMPROVE improvement information Institutional Repository manuscript Metadata phenotypic phenotypic information Repository Research resources resulting submission Support term use cases [DOI] 10.1093/nar/gkab1046 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
COVID19db: a comprehensive database platform to discover potential drugs and targets of COVID-19 at whole transcriptomic scaleCOVID19db: 전체 전사체 규모에서 COVID-19의 잠재적 약물 및 표적을 발견하기 위한 포괄적인 데이터베이스 플랫폼AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] 유전자 메커니즘, 치료제, [키워드] accelerate Analysis clinical information coronavirus disease Coronavirus disease 2019 COVID-19 database dataset datasets drug Effective strategies effective strategy facilitate grouping heterogeneity identify include Interaction mandatory mechanism microbe Open Access platform proof proof of concept provide researcher target targets Transcriptome transcriptomes transcriptomic transcriptomic data [DOI] 10.1093/nar/gkab850 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
The recombinant pseudorabies virus expressing porcine deltacoronavirus spike protein is safe and effective for miceResearch Published on 2022-01-042022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] accelerate acute diarrhea antibody BHK-21 booster candidate vaccine caused CD4 CD8 Cell coronavirus country death disease economic loss effective evaluated expected expressing expression level Genetic Homologous recombination IFN-γ IL-4 Immunity immunization immunogenicity intestinal lymphocyte mice neutralizing antibody pathogenic PDCoV Peripheral blood Porcine deltacoronavirus proliferation PROTECT protective efficacy Protein reached Recombinant pseudorabies virus Result Safe specific antibody Spike protein spleen stability supplementary material T lymphocyte up-regulated Vaccine virulent virus vomiting was increased [DOI] 10.1186/s12917-021-03115-1 PMC 바로가기 [Article Type] Research
Machine Learning and Artificial Intelligence in Pharmaceutical Research and Development: a Review제약 연구 및 개발의 기계 학습 및 인공 지능: 검토Review Published on 2022-01-042022-09-11 Journal: The AAPS Journal [Category] 비임상, [키워드] accelerate Analysis anticipated approach artificial artificial intelligence automated breath clinical clinical trial Clinical trial design clinical trials COVID-19 pandemic Critical driven by drug Drug development Drug discovery Efficiency expected help Hope increase in Inference inferences intelligence machine machine learning manuscript market occur offer over Patient pharmaceutical pharmaceutical industry positive precision medicine Predictive Predictive modeling Probability of success recognize Research research and development review Risk-based monitoring. Trial utilization Volume [DOI] 10.1208/s12248-021-00644-3 PMC 바로가기 [Article Type] Review
The real economic costs of COVID-19: Insights from electricity consumption data in Hunan Province, ChinaResearch article Published on 2022-01-012022-10-05 Journal: Energy Economics [Category] 변종, [키워드] accelerate caused changed China COVID-19 COVID-19 outbreak COVID-19 pandemic declines develop Difference-in-differences dropped early stage economic growth electricity Electricity consumption events extreme fluctuations Government heterogeneity impacts insight Internet magnitude measure offset Prevent suffered Support The real economic cost virus [DOI] 10.1016/j.eneco.2021.105747 [Article Type] Research article
Quality comparability assessment of a SARS-CoV-2-neutralizing antibody across transient, mini-pool-derived and single-clone CHO cells일시적인 미니 풀 유래 및 단일 클론 CHO 세포 전반에 걸친 SARS-CoV-2 중화 항체의 품질 동등성 평가Comparative Study Published on 2022-01-012022-09-12 Journal: mAbs [Category] SARS, 진단, [키워드] accelerate acute respiratory syndrome adopted Cell cell line Chemistry Chinese hamster CHO cell clinical trial comparability comparable conducted Control coronavirus Degradation immunological functions indicated measure mini-pool monoclonal antibody Neutralizing neutralizing antibody patients Phase 1 profiles public health crisis Quality Research SARS-CoV-2 SARS-CoV-2-neutralizing antibody Spike protein stress condition structures Support the disease the SARS-CoV-2 therapeutic transient. triggered Variation [DOI] 10.1080/19420862.2021.2005507 PMC 바로가기 [Article Type] Comparative Study