Animal Models for COVID-19: More to the Picture Than ACE2, Rodents, Ferrets, and Non-human Primates. A Case for Porcine Respiratory Coronavirus and the Obese Ossabaw PigMicrobiology Published on 2020-09-252022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE2 ACE2 protein angiotensin-converting enzyme 2 animal animal model bind binding cardiovascular disease caused Comorbidity COVID COVID-19 COVID-19 pandemic COVID-19 patient Critically ill determine diabetes diagnostics disease Express healthy hospitals host cell receptor Infection infection with SARS-CoV-2 investigated majority mechanism metabolic syndrome Mild Model MOST Non-human non-human primates obese obesity occur occurred Ossabaw pig outcome pig primates Research respiratory Respiratory Coronavirus rodents SARS-CoV-2 severe COVID-19 Spike protein susceptible syndrome transgenic Vaccines viral spike protein virus [DOI] 10.3389/fmicb.2020.573756 PMC 바로가기 [Article Type] Microbiology
Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tractResearch Paper Published on 2020-09-212022-11-01 Journal: EBioMedicine [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 mRNA ACE2 protein Alveolar Type II alveolar type II cells apical surface association caused Cell children ciliated cells cofactor coronavirus correlation COVID-19 COVID-19 pandemic determine disease disease severity evaluated examined expression Factor Factors finding highest Host human respiratory tract immunohistochemistry incidence interactions Lower respiratory tract lung lung parenchyma material mRNA abundance Numerous offer outbreak protein levels question raise receptor receptor ACE2 reduced Region responsible risk factor SARS-CoV-2 SARS-CoV-2 susceptibility SARS-CoV2 severe COVID-19 severe disease Single-cell RNA sequencing subset susceptibility tissue TMPRSS2 Transmission transmitted Viral transmission [DOI] 10.1016/j.ebiom.2020.102976 PMC 바로가기 [Article Type] Research Paper
Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune PerspectiveImmunology Published on 2020-09-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 protein ACE2 proteins adhere animal model antibodies antibody binding-affinity block blocking caused classical Combination comparison COVID-19 Critical crystal structure develop effective eight epithelial epithelial cells epitope felines Host Human human ACE2 IgA dimer Infection Interaction interaction-synapse interactions interface interfere intestine Multiple Neutralizing antibodies neutralizing antibody pandemic Protein protein-protein interaction Proteins SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 transmission significant difference single antibody spike therapeutic therapy treating COVID-19 Vaccine virus X-ray [DOI] 10.3389/fimmu.2020.570018 PMC 바로가기 [Article Type] Immunology
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2Observation Published on 2020-09-102022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] ACE2 ACE2 mRNA ACE2 protein activity acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral antiviral action antiviral activity antiviral drug antiviral gene approved benefit bronchial epithelial cells canonical Cell cell line clinical trial clinically coronavirus coronavirus disease counterbalance COVID-19 COVID-19 therapeutics Critical cytokine deaths dose-dependent manner Ebola virus Effect effector elevated ENhance entry receptor exacerbate exhibited expression help hepatitis C virus highlight HIV Host human lung I, II IFN IFN treatment IFN-β IFN-γ IFN-λ IFN-λ1 IFNs immune Immunotherapy Infection inhibited Innate immune defense interferon interferons investigated ISG ISG response ISGs limit mechanism mRNA pandemic produced raising receptor receptors repurposing Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 replication Severe infection Side effects surface protein the SARS-CoV-2 therapy Threats transcript treat Type type I upregulated upregulating virus entry virus replication viruses [DOI] 10.1128/mBio.01928-20 PMC 바로가기 [Article Type] Observation
Exploring the Demographics and Clinical Characteristics Related to the Expression of Angiotensin-Converting Enzyme 2, a Receptor of SARS-CoV-2Medicine Published on 2020-08-192022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval ACE2 ACE2 expression ACE2 mRNA ACE2 protein age analyzed angiotensin covering enzyme II angiotensin-converting enzyme 2 association Blood Cancer cellular entry receptor clinical Clinical characteristics Coronavirus disease 2019 correlation COVID-19 demographic diabetes disease ELISA assay enrolled expression Factor female female subject females form Gender higher risk hypertension identify increased risk individual Infection linear Linear regression analysis Logistic regression analysis male Multiple Multiple linear regression Odds ratio Older age older subjects Pearson performed polymerase chain questionnaire regression analysis reported SARS-CoV-2 Smokers smoking Spread statistically significant student subject subjects susceptibility susceptible t -test was used Wuhan, China [DOI] 10.3389/fmed.2020.00530 PMC 바로가기 [Article Type] Medicine
Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?Original Research Paper Published on 2020-08-182022-10-31 Journal: Metabolism Open [Category] COVID-19, [키워드] ACE2 ACE2 protein age angiotensin-converting enzyme 2 angiotensinogen aptamer blood pressure blood vessels BMI Cell Cohort condition COVID-19 infection CRP described diabete diastolic elevated high risk hypertension independent inherent insulin resistance intestines kidneys Lungs obesity plasma Plasma level plasma protein Polycystic ovary syndrome Protein RAS receptor Renin Result risk SARS-CoV-2 SARS-CoV-2 coronavirus Severe COVID-19 Infection severe disease slow syndrome System T2D target cell Type type 2 diabete Waist circumference women [DOI] 10.1016/j.metop.2020.100052 PMC 바로가기 [Article Type] Original Research Paper
Holistic Analysis of Coronavirus Literature: A Scientometric Study of the Global Publications Relevant to SARS-CoV-2 (COVID-19), MERS-CoV (MERS) and SARS-CoV (SARS)Brief Report Published on 2020-08-132022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, MERS, SARS, [키워드] ACE2 protein acute respiratory syndrome Asia Bibliometrics caused China Cluster Collection coronavirus coronavirus disease country COVID-19 database disease distribution Europe Genetic Germany investigated MERS MERS-CoV Netherland Novel coronavirus outbreak pathogen patients with pneumonia produced reported SARS SARS-CoV SARS-CoV-2 Scientometrics the disease the United State United Kingdom United States virus Web of Science while Wuhan [DOI] 10.1017/dmp.2020.300 PMC 바로가기 [Article Type] Brief Report
Can ACE 2 expression explain SARS ‐CoV‐2 infection of the respiratory epithelia in COVID ‐19?News & Views Published on 2020-07-262022-10-31 Journal: Molecular Systems Biology [Category] COVID-19, SARS, [키워드] ACE ACE2 ACE2 protein acute respiratory distress acute respiratory syndrome airway epithelium angiotensin Can Cell characterized coronavirus disease COVID early stage enzyme explain expressed expression Health host cell Infection initial lung parenchyma mechanism Methods & Resources Microbiology, Virology & Host Pathogen Interaction pandemic progression Protein respiratory epithelia respiratory epithelial cells responsible SARS‐CoV‐2 severe disease suggested syndrome WHO World Health Organization [DOI] 10.15252/msb.20209841 PMC 바로가기 [Article Type] News & Views
Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS‐CoV‐2 main protease and ACE2 proteinResearch Article Published on 2020-07-062022-10-31 Journal: Food Frontiers [Category] COVID-19, [키워드] Ipomoea Obscura (L.) ACE2 ACE2 protein ADME Analysis angiotensin converting enzyme Antiviral effect Compound determine evaluate exhibit GC‐MS Genome host cell host cells inhibitor inhibitory activity involved Ipomoea molecular docking Molecular docking study Pro protease Replication Result SARS‐CoV‐2 SARS‐CoV‐2 suggested target protein target proteins viral genome viral replication [DOI] 10.1002/fft2.29 PMC 바로가기 [Article Type] Research Article
The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19Review article Published on 2020-06-252022-10-05 Journal: Molecular Therapy [Category] 유전자 메커니즘, [키워드] ACE ACE2 ACE2 protein ACE2 receptor ACEi acute respiratory syndrome angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor angiotensin-renin system antihypertensive drugs antihypertensive medication ARB ARBs association binding blood pressure blood pressure homeostasis coronavirus coronavirus disease COVID-19 Critical debatable Deleterious Effectiveness evaluate examined expression face Genetic Genetic variant genetic variants host cell hypertension infected with SARS-CoV-2 Infection involved mechanism modulate modulating mortality rate Patient populations question receptor reducing risk role SARS-CoV-2 susceptibility therapy virus [DOI] 10.1016/j.omtm.2020.06.017 [Article Type] Review article