Adult patients – Page 11 – Communicable Diseases Research

Corticosteroids for Patients With Coronavirus Disease 2019 (COVID-19) With Different Disease Severity: A Meta-Analysis of Randomized Clinical Trials

질병 중증도가 다른 코로나바이러스 질병 2019(COVID-19) 환자를 위한 코르티코스테로이드: 무작위 임상 시험의 메타 분석

Meta-Analysis

Published on 2021-02-012022-09-11
Journal: Journal of cardiothoracic and vascular anesthesia [Category] 임상,

Evaluation of convalescent plasma versus standard of care for the treatment of COVID-19 in hospitalized patients: study protocol for a phase 2 randomized, open-label, controlled, multicenter trial

입원 환자의 COVID-19 치료에 대한 회복기 혈장 대 치료 표준 평가: 2상 무작위, 공개, 대조, 다기관 시험을 위한 연구 프로토콜

Study Protocol

Published on 2021-01-202022-09-10
Journal: Trials [Category] MERS, 임상,

[키워드] 1:1 7-point ordinal scale Acute respiratory infection acute respiratory infections Administered Adult patients Analysis antibodies assigned cause caused center clinical trial Complete conducted contribute Controlled trial convalescent plasma Convalescent plasma (CP) COVID-19 COVID-19 infection COVID-19 pneumonia effective Efficacy Efficacy and safety enrolled etiology evaluate expected futility Hospitalized hospitalized patients immune response Immunotherapy include infected patient infected patients Interim Interim analyses intravenously invasive mechanical ventilation morbidity and mortality multicenter Multicenter trial Neutralizing antibodies Non-invasive Novel coronavirus Open-label option Ordinal Scale Patient patients hospitalized pharmacological primary endpoint proportion protocol Randomized Randomly receive respiratory Respiratory disease Sample size SARI SARS-CoV-2 Severe COVID-19 Infection Severe COVID-19 pneumonia severity Standard of care stratified Study protocol supplementary material the WHO therapeutic agent therapeutic agents Therapeutics Treatment treatment arm Trial registration Vaccine variety Viral viral disease with COVID-19
[DOI] 10.1186/s13063-020-05011-9 PMC 바로가기 [Article Type] Study Protocol

Central and peripheral nervous system complications of COVID-19: a prospective tertiary center cohort with 3-month follow-up

COVID-19의 중추 및 말초 신경계 합병증: 3개월 추적 관찰이 있는 예비 3차 센터 코호트

Observational Study

Published on 2021-01-132022-09-10
Journal: Journal of Neurology [Category] MERS, SARS, 임상, 치료기술,

[키워드] Admission Adult patients akinetic mutism biopsy caused causes cerebrospinal fluid change CNS Cohort collected Complication conducted coronavirus COVID-19 COVID-19 patients Critical Critical illness discharge during admission Electronic health records Encephalitis Encephalopathy enrolled Follow-up hospitalized COVID-19 patients ICU ICU admission Immune-mediated independent Intensive intensive care investigated Ischemic Stroke Laboratory Length management mechanisms meralgia meralgia paresthetica Myelitis nervous system neurological Neurological disease Neuropsychiatric non-ICU non-ICU patients objective observational study Other Patient remained required Respiratory failure Result SARS-CoV-2 SARS-CoV-2 neurotropism SARS-CoV-2 RNA screened secondary to stroke suggested supplementary material Symptom transverse myelitis Viral
[DOI] 10.1007/s00415-020-10380-x PMC 바로가기 [Article Type] Observational Study

Hydroxychloroquine in the treatment of adult patients with Covid-19 infection in a primary care setting (LIBERTY): A structured summary of a study protocol for a randomised controlled trial

일차 진료 환경(LIBERTY)에서 Covid-19 감염 성인 환자 치료에 사용되는 하이드록시클로로퀸: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-01-112022-09-10
Journal: Trials [Category] MERS, 임상,

[키워드] 1:1 addition addressed administration Adult patients adverse event adverse events AEs age all-cause hospitalization Antibody Response Anxiety Anxiety Disorder ARMS association Biomarker blinded Blinding Blood BMI capture Care changes changes in Characteristics clinical trial concentrations concomitant medications conducted Contact Course COVID-19 COVID-19 infection COVID-19-related symptoms criteria death deleting Demographic variables diabetes Diabetes Mellitus disease dissemination double-blind Effect element enrolment enzyme EudraCT evaluate exclusion expected exploratory exploratory endpoint Exploratory endpoints female Formulation GAD-7 Generalized Generalized Anxiety Disorder Genetic variation HCQ Health care HLA haplotypes hospital Hospitalization hospitalizations Hydroxychloroquine Hypothesis identify include Inclusion independent individual Infection information intensive care unit lactation masking mental health Meta-analysis Mortality Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples number number of deaths objective onset of symptom open care outcome Outpatient outpatients parallel-group participant Patient patient data PCR test PCR testing PCR-confirmed Placebo placebo-controlled post-hoc predict Pregnancy presenting primary care primary endpoint protocol public health public health care randomised randomised controlled trial randomization list Randomized Randomly receive recruitment reduce Registered Regulation repeated reported respiratory respiratory distress respiratory rate response risk room air SAEs Sample size SARS-CoV-2 SARS-CoV-2 PCR test SARS-CoV-2 viral shedding Satakunta secondary endpoint Secondary endpoints Secondary objectives serious AE serum Seven severe pneumonia severity specific treatment status study participant Study participants study population Study protocol subgroup analysis subject supplementary material Suspected Symptom Symptoms technology test result therapeutic potential Tolerability treated Treatment treatment allocation treatment arm Trial Trial registration twice a day type 1 or type 2 Uppsala variable Viral was performed website Well-being
[DOI] 10.1186/s13063-020-04989-6 PMC 바로가기 [Article Type] Letter

Double-blind, randomized, controlled, trial to assess the efficacy of allogenic mesenchymal stromal cells in patients with acute respiratory distress syndrome due to COVID-19 (COVID-AT): A structured summary of a study protocol for a randomised controlled trial

COVID-19(COVID-AT)로 인한 급성 호흡 곤란 증후군 환자에서 동종 간엽 기질 세포의 효능을 평가하기 위한 이중 맹검, 무작위, 대조 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-01-062022-09-10
Journal: Trials [Category] MERS, 바이오마커, 임상, 치료제,

[키워드] 1:1 24 hours 7-point ordinal scale acute respiratory distress acute respiratory distress syndrome Administered administration Admission Adult patient Adult patients Adverse Adverse drug reactions AEs age All trial participants all-cause mortality allergy Allogeneic ARDS assessment assigned baseline Biomarker blinded Blinding C-reactive protein carcinoma carcinoma in situ carried cellular chain change childbearing potential Chloroquine Clinical practice clinical status clinical trial coagulation test coagulation tests conducted Control control arm Course COVID COVID-19 CRF criteria CT scan cumulative incidence current Cytokines D-dimer Day death described determined by Diagnosis disease dissemination double-blind drug Duration ECMO Efficacy Efficacy and safety element eligible End endpoints enrolment EudraCT evaluate evaluate the effect event exclusion criteria Extracorporeal extracorporeal membrane oxygenation failure ferritin fibrosis FiO2 form GRADE grade 3 greater Haemodialysis handling hemofiltration history hospital Hospitalization hydroxy ICU ICU admission IMPROVE include inclusion criteria Informed consent intravenous Intravenous administration intravenous dose intubation Invasive mechanical ventilation invasive ventilation investigational medicinal product involved laboratory confirmation laboratory-confirmed SARS-CoV-2 infection lactation LDH less Level Local Lopinavir Lopinavir/ritonavir lung disorder lymphocyte marker Mechanical mechanical ventilation Medicine Medicines Mesenchymal stromal cells moderate to severe Mortality MSC negative pregnancy test neoplasm neutrophil neutrophil counts Non-invasive number objective occur off-label opinion Ordinal Scale organ oropharyngeal swab oropharyngeal swabs Other outcome oxygen oxygen saturation Oxygen therapy PaO2 PaO2/FiO2 ratio parameters participant Patient PCR percentage Placebo polymerase chain reaction Pregnancy primary endpoint product Production profile progression protocol Pulmonary embolism pulmonary fibrosis Pulmonary function tests randomised randomised controlled trial randomization Randomized Randomly Rapid antigen tests reaction receive recruitment Registered Remdesivir report respiratory Respiratory distress syndrome Resuscitation Ritonavir SAEs Sample size SARS-COV-2 infection secondary Secondary endpoints Sequential Organ Failure Assessment Serious Adverse Events SOFA Spain specificity specimen Sponsor Standard of care status stromal cell stromal cells Study protocol subpopulations supplemental oxygen supplementary material syndrome the cell the disease the patient the primary endpoint the WHO time Tocilizumab Tolerability Treatment treatment arm treatment for COVID-19 treatment group Treatment protocol Trial trial participant Trial registration unit website women worldwide pandemic written consent
[DOI] 10.1186/s13063-020-04964-1 PMC 바로가기 [Article Type] Letter

Risk factors for illness severity in patients with COVID-19 pneumonia: a prospective cohort study

COVID-19 폐렴 환자의 질병 중증도에 대한 위험 요인: 전향적 코호트 연구

Comparative Study

Published on 2021-01-012022-09-10
Journal: International Journal of Medical Sciences [Category] MERS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adult patients albumin Analysis aspartate Aspartate aminotransferase AST C-reactive protein C-reactive protein (CRP case sery case-control study China city Clinical characteristics Cohort coronavirus COVID-19 COVID-19 pneumonia COVID-19 pneumonia patients demographics demonstrated Diagnosis disease severity Early detection enrolled Factor fatigue Glucose identify illness onset Illness severity Infectious disease knowledge Laboratory laboratory findings Lactate lactate dehydrogenase LDH lymphocyte Lymphocyte count lymphocyte counts neutrophil neutrophil count neutrophil counts NLR Novel coronavirus Patient patients patients with COVID-19 percentage Platelet Pneumonia predict predictor prospective cohort study prospective studies remained respiratory risk factor Risk factors SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe patients severity severity of COVID-19 severity of illness sex- Shortness of breath single-center the disease
[DOI] 10.7150/ijms.51205 PMC 바로가기 [Article Type] Comparative Study

Low-to-moderate dose corticosteroids treatment in hospitalized adults with COVID-19

COVID-19로 입원한 성인에서 중등도 용량의 코르티코스테로이드 치료

Article

Published on 2021-01-012022-09-11
Journal: Clinical microbiology and infection : the official [Category] SARS, 치료제,

[키워드] 1:1 95% CI Administered administration Admission Adult patients Analysis association clinical effectiveness Clinical improvement Clinical outcome clinical outcomes coronavirus disease Coronavirus disease 2019 Corticosteroid corticosteroid therapy corticosteroid treatment Corticosteroids corticosteroids therapy covariate COVID-19 COVID-19 patient COX Cox proportional hazard Cox proportional hazards regression model dead death rate discharged dose hazard high-flow oxygen therapy Hospitalized hospitalized COVID-19 patients In-hospital death in-hospital mortality IQR log rank mechanical ventilation Mortality multivariable nasal no significant difference no significant differences outcome oxygen Oxygen therapy Patient patients performed propensity score matching proportional hazards model Regression model required retrospective cohort study SARS-CoV-2 SARS-CoV-2 pneumonia significant differences Treatment was used with COVID-19
[DOI] 10.1016/j.cmi.2020.09.045 PMC 바로가기 [Article Type] Article

Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19

사이토카인 폭풍의 특성은 COVID-19의 과염증성 내피 기능 장애를 반영합니다

Article

Published on 2021-01-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADP-ribose Adult patients age Analysis analyzed assays association attenuate Baricitinib Biomarker Biomarkers blood sample Blood samples cardiovascular cardiovascular disease characterization characterized circulating circulation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CXCL10 CXCL5 CXCL9 cytokine Cytokine storm Cytokine storms disease severity dominant dysregulation endothelial damage Endothelial dysfunction healthy control healthy controls help host inflammatory response host response Hyperinflammatory identify IFN-γ IL-10 IL-1ra IL-6 immune response immune responses increasingly Infection Inflammation Intervention marker MCP-3 mechanism Mild moderate monocyte observé Ordinal Scale Pathogenesis Patient patients hospitalized patients with COVID-19 physician platform polymerase Protein proteomic pursuit reduce reflect Regulation reliability reproducibility respiratory Result scale severe acute respiratory syndrome Coronavirus Spectrum statistically significant stratified the cytokine storm therapeutic options Vascular with COVID-19
[DOI] 10.1016/j.jaci.2020.08.031 PMC 바로가기 [Article Type] Article

Biomarkers of acute respiratory distress syndrome in adults hospitalised for severe SARS-CoV-2 infection in Tenerife Island, Spain

스페인 테네리페 섬에서 중증 SARS-CoV-2 감염으로 입원한 성인의 급성 호흡곤란 증후군 바이오마커

Observational Study

Published on 2020-12-092022-08-31
Journal: BMC Research Notes [Category] 바이오마커, 임상,

[키워드] acute respiratory distress acute respiratory distress syndrome Acute respiratory failure Admission Adult patients ARDS Biomarker Biomarkers C-reactive protein Complication correlated COVID-19 criteria d -dimer defined develop evaluated ferritin FiO2 help hospital hospitalised identify Infection island Laboratory test Laboratory tests Lactate lactate dehydrogenase LDH lymphocyte lymphocyte counts negative correlation objective oxygen Patient patients with ARDS poor prognosis predict pulse respiratory distress Respiratory function Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe SARS-CoV-2 Spain SpO2 SpO2/FiO2 Spread syndrome the mean
[DOI] 10.1186/s13104-020-05402-w PMC 바로가기 [Article Type] Observational Study

Deep-learning algorithms for the interpretation of chest radiographs to aid in the triage of COVID-19 patients: A multicenter retrospective study

COVID-19 환자 분류에 도움이 되는 흉부 방사선 사진 해석을 위한 딥 러닝 알고리즘: 다기관 후향적 연구

Multicenter Study

Published on 2020-11-242022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술,

[키워드] Accuracy Adult patients Algorithm all the patients Chain Reaction Chest Chest computed tomography chest CT scan Chest CT scans Chest radiography Clinical efficacy clinician Community comparable Computed tomography consolidation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 pneumonia demonstrated diagnose diagnosed Diagnosis diagnostic Efficacy Emergency Departments evaluate evaluated Evidence evidence of facilitate FIVE Formal ground-glass opacity infiltration Interpretation Isolation medical staff multicenter offer outcomes Patient physician Pneumonia polymerase chain polymerase chain reaction positive positive COVID-19 radiologist Radiologists reduce Retrospective study reverse transcription reverse transcription polymerase chain reaction Sensitivity and specificity significantly speed the patient Treatment were used
[DOI] 10.1371/journal.pone.0242759 PMC 바로가기 [Article Type] Multicenter Study