Characteristics of Viral Shedding in Respiratory Samples and Specific Antibodies Production in 564 COVID-19 Patients564명의 COVID-19 환자에서 호흡기 샘플 및 특정 항체 생산의 바이러스 배출 특성Article Published on 2021-02-012022-09-12 Journal: Current medical science [Category] MERS, 진단, [키워드] accounted age antibody antibody production antibody tests branch changes in city collected Concentration concentrations correlated correlation COVID-19 COVID-19 patient COVID-19 patients Day discharge discharged disease severity Gender had no IgG and IgM IgM Inpatient median nasopharyngeal swabs New nucleic acid Patient patients positive positive rate Production proportion quarantine reduce Reporting respiratory respiratory sample Sample SARS-CoV-2 shedding significantly Specific specific antibodies specific antibody sputum suggested symptom onset the patient throat swabs Tongji Hospital viral shedding were recorded [DOI] 10.1007/s11596-021-2316-3 PMC 바로가기 [Article Type] Article
Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19경증 대 중증 COVID-19 동안 SARS-CoV-2에 특이적인 전신 및 점막 항체 반응Article Published on 2021-02-012022-09-12 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory distress acute respiratory syndrome age antibody production Antibody Response Antibody test cohorts coronavirus correlated COVID-19 COVID-19 seroprevalence COVID-19 severity determinant develop disease evaluate Health care worker humoral humoral immune response IgA IgA titer IgG IgG titer immune immunoassay increasingly Mild mucosal mucosal immune mucosal immune response. nasal fluid Patient PCR-positive PCR-positive patient positive Prevalence remained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike proteins SARS-CoV-2-specific antibody SARS-CoV-2–specific antibodies SARS-CoV-2–specific IgA SARS-CoV-2–specific IgG secretion sera serum serum antibody serum IgG severe coronavirus disease severe COVID-19 significant increase stimulate symptom onset syndrome systemic virus-neutralizing [DOI] 10.1016/j.jaci.2020.10.040 PMC 바로가기 [Article Type] Article
Systemic and intestinal porcine epidemic diarrhea virus-specific antibody response and distribution of antibody-secreting cells in experimentally infected conventional pigsResearch Article Published on 2021-01-042022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] antibody antibody production Antibody Response antibody-secreting cell antibody-secreting cells ASC B-cell characterized Colon contribute coronavirus disease Course Diagnostic method diarrhea distribution effective vaccine Efficacy epidemic diarrhea epithelial cell fecal samples fluctuation IgA immune response in vitro individual infect Infection Infectious disease intestinal Lymph node memory B cell mucosal mucosal immune responses PEDV Porcine epidemic diarrhea virus predict protective immunity replicate secrete serum Spread systemic Vaccine virus virus clearance [DOI] 10.1186/s13567-020-00880-z PMC 바로가기 [Article Type] Research Article
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial Research Published on 2020-12-172022-10-05 Journal: Nature Medicine [Category] SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory syndrome Adenovirus Adults antibody production Antibody Response antigen-specific T cell AZD1222 caused CD4+ T cell CD8+ T cells cell-mediated immune cell-mediated immune response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine characterized clinical trial contribute coronavirus COVID-19 cytokine secretion Cytotoxic T cell disease effective vaccine Efficacy Exploratory analysis expressing full-length SARS-CoV-2 global pandemic host cell humoral IgG1 IgG3 Immune profile immune response immunogenicity data infected with SARS-CoV-2 interferon-γ neutralizing antibody Patient phase 2/3 trial Phenotypes progression Protective protective role reduce reported Safe SARS-CoV-2 SARS-CoV-2 vaccine single dose Spike protein Strong suggested T cell T cell response the SARS-CoV-2 Trial tumor necrosis factor-α two-dose regimen vaccination Vaccine vaccine candidate [DOI] 10.1038/s41591-020-01194-5 [Article Type] Research
The Multiple Functions of B Cells in Chronic HBV InfectionReview Published on 2020-12-142023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] antibody production Antigen presentation B cell Hepatitis B virus immune regulation Immunotherapy [DOI] 10.3389/fimmu.2020.582292 PMC 바로가기 [Article Type] Review
Baricitinib restrains the immune dysregulation in patients with severe COVID-19Clinical Trial Published on 2020-12-012022-10-05 Journal: The Journal of Clinical Investigation [Category] SARS, 임상, [키워드] anti-SARS-CoV-2 antibody antibody production approved B cell Baricitinib blood cell change circulating Clinical outcome clinically coronavirus disease correlated COVID-19 cytokine level cytokine release develop Disabled evaluated Evidence expression extreme fraction frequencies functional IL-1β IL-6 immune immune dysregulation Immune phenotype Immunity immunology increase in Inflammatory response Innate Innate immunity JAK/STAT signaling Local lymphopenia modulating myeloid cell need for oxygen off-label oxygen P/F PaO2 Pathways Patient patients treated patients with COVID-19 per day phosphorylated Pneumonia prevented progression reduction in regulated Serum level severe COVID-19 Spike protein STAT3 supported the patient the SARS-CoV-2 therapy TNF-α transcriptionally treated Trial viral disease [DOI] 10.1172/JCI141772 PMC 바로가기 [Article Type] Clinical Trial
The Role of Vitamin C, Vitamin D, and Selenium in Immune System against COVID-19Review Published on 2020-11-162022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] antibody production Antiviral antiviral cytokine attenuate Clinical outcome coronavirus disease COVID-19 COVID-19 patient Cytokine storm Defense diagnosed effector cells ENhance Excessive activation excessive inflammatory response free radical formation functions Hyperactivation immune cells immune response immune system Immunity IMPROVE increase infections Infectious disease Inflammatory cytokines maturation Micronutrient Patient peptides physical barrier Prevent recent Respiratory tract infections risk role Selenium selenium deficiency shown stimulate survival rate System T cell Trace element viral infections virus Vitamin Vitamin C Vitamin D [DOI] 10.3390/molecules25225346 PMC 바로가기 [Article Type] Review
Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy volunteers up to 6 months post disease onset질병 발병 후 최대 6개월까지 COVID-19 환자 및 건강한 지원자에서 항-SARS-CoV-2 항체의 혈청유병률Clinical Trial Published on 2020-11-102022-08-13 Journal: European Journal of Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] age Anti‐SARS‐CoV‐2 antibody response Anti‐SARS‐CoV‐2 antibody responses anti‐SARS‐CoV‐2 IgG antibody antibody antibody production Antibody Response Antibody titer Asymptomatic circulating classic Clinical signs COVID‐19 COVID‐19 patient COVID‐19 described detect detectable disease onset Fever healthcare Healthcare workers healthy volunteer highlight hospital human pathogen humoral immune response IgA antibodies IgA antibody IgG IgG antibodies IgM immune response immunological information initial longitudinal analysis men Mild MONITOR neutralising antibody neutralization activity Neutralizing antibodies Patient peaking proportion protective immunity Protein provide quantified rapid increase RBD receptor‐binding domain recognizing reduce remained robust SARS‐CoV‐2 SARS‐CoV‐2 screened Seroprevalence setup Severity of disease Spread subject subjects Symptoms tested the Spike titre titres university virus volunteers were infected [DOI] 10.1002/eji.202048970 PMC 바로가기 [Article Type] Clinical Trial
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2Article Published on 2020-11-042022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] ACE2 binding ACE2 binding site Analysis antibody production approach bind Biochemistry Biophysics coronavirus SARS-CoV-2 costly COVID-19 COVID-19 pandemic cryo-EM cryo-EM structure high affinity Infectious diseases Isolation Molecular medicine nanobody nanomolar affinity neutralization activity neutralize neutralized Neutralizing activity neutralizing antibody Pseudotyped viruses pseudovirus RBD SARS-CoV-2 SARS-CoV-2 spike protein Selection spike Spike protein Structural analysis structural biology sybody synthetic nanobody the receptor-binding domain the SARS-CoV-2 viruses [DOI] 10.1038/s41467-020-19204-y PMC 바로가기 [Article Type] Article
Nucleic acid and antibody assay results in Chinese patients with coronavirus disease 2019 (COVID-19)Article Published on 2020-10-122022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 진단, [키워드] age alanine aminotransferase analyzed antibodies antibody antibody production antibody test result C-reactive protein CD19 CD4 CD8 cell count chain Characteristics China Chinese patient clinical coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 creatinine died discharge electronic medical records evaluate group groups IgG antibody IgM IL-6 individual Laboratory Laboratory test laboratory-confirmed SARS-CoV-2 infection lactate dehydrogenase male mild symptoms MOST Nasopharyngeal samples no difference no significant difference nucleic acid nucleic acids Patient patients positive producing Re-positivepatients reaction Result RT-PCR SARS-CoV-2 sputum Stool tested three group Treatment [DOI] 10.1016/j.intimp.2020.107089 PMC 바로가기 [Article Type] Article