Dominant CD8 + T Cell Nucleocapsid Targeting in SARS-CoV-2 Infection and Broad Spike Targeting From VaccinationSARS-CoV-2 감염에서 우세한 CD8 + T 세포 뉴클레오캡시드 표적화 및 백신 접종으로 인한 광범위한 스파이크 표적화Immunology Published on 2022-02-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] anti-SARS-CoV-2 Anti-spike Antibody Response Antibody responses assays average boost breadth CD8 CD8+ T cells Cellular immune response cellular immunity Coverage COVID-19 COVID-19 symptom COVID-19 vaccine demonstrated density dominant ELISpot assays envelope protein envelope proteins epitope Epitopes evaluated Evaluating flow cytometry greater IFN-γ IFN-γ ELISPOT IL-4 Inclusion magnitude nucleocapsid persistence predicted protective role Receptor binding domain Region regions response responses against SARS-CoV-2 SFC spike spot-forming cell spot-forming cells subset sustained T cell T cell response T cell responses T cells targeting Th1 vaccination Vaccine Viral viral infections while [DOI] 10.3389/fimmu.2022.835830 PMC 바로가기 [Article Type] Immunology
A cell-based system combined with flow cytometry to evaluate antibody responses against SARS-CoV-2 transmembrane proteins in patients with COVID-19코로나19 환자의 SARS-CoV-2 막관통 단백질에 대한 항체 반응을 평가하기 위해 유세포 분석과 결합된 세포 기반 시스템Article Published on 2022-02-222022-09-11 Journal: STAR protocols [Category] COVID19(2023년), SARS, 변종, [키워드] antibody Antibody Response Antibody responses approach Biology Cell Biology Cell-based Assays Complete Effectiveness evaluate Flow flow cytometry Flow Cytometry/Mass Cytometry glycosylation Health Sciences HEK293T cell HEK293T cells host cells insertion Laboratory membrane membrane protein Microbiology Molecular biology N-glycosylation patient sera patients with COVID-19 powerful tool protocol SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants transmembrane protein Vaccine viral infection [DOI] 10.1016/j.xpro.2022.101229 PMC 바로가기 [Article Type] Article
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variantsSARS-CoV-2 감염 전후에 백신 접종은 강력한 체액 반응과 변이체를 효과적으로 중화시키는 항체로 이어집니다.Article Published on 2022-02-182022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] age antibody Antibody Response Antibody responses antigen exposure boost breadth Breakthrough infection breakthrough infections coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current Effect groups humoral humoral immune response immune immune response immune responses Immunity individual Infection morbidity and mortality natural infection neutralize Neutralizing antibody response neutralizing antibody responses no correlation no infection occur pandemic quantity reduce respiratory Respiratory Coronavirus robust SARS-CoV-2 SARS-COV-2 infection sera vaccinated individuals vaccination Vaccine variant [DOI] 10.1126/sciimmunol.abn8014 PMC 바로가기 [Article Type] Article
Intensity and Dynamics of Anti-SARS-CoV-2 Immune Responses after BNT162b2 mRNA Vaccination: Implications for Public Health Vaccination StrategiesArticle Published on 2022-02-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Affect age Antibody responses Autoimmune disease automated BNT162b2 BNT162b2 mRNA cell-mediated immune response cellular response Cellular responses correlation COVID-19 COVID-19 infection COVID-19 vaccination demonstrated dose Dynamics ELISA assays enrolled evaluated first dose first vaccination humoral Humoral response IgA IgA response IgA titer IgG IgG response IgG responses immunization implication individual information intensity Laboratory majority median Microparticle of BNT162b2 Participants positive antibody response positively correlated Public public health required response second vaccination significantly Strategy systemic adverse reaction T cell responses vaccinated individuals vaccination Vaccination strategies were assessed [DOI] 10.3390/vaccines10020316 PMC 바로가기 [Article Type] Article
Metrics from Wearable Devices as Candidate Predictors of Antibody Response Following Vaccination against COVID-19: Data from the Second TemPredict StudyArticle Published on 2022-02-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Activation adjusted antibody Antibody Response Antibody responses association baseline candidate collected correlated COVID-19 COVID-19 vaccination COVID-19 vaccinations COVID-19 vaccines decrease deviation Device domain greater heart rate heart rate variability immune protection increases in independent information injection investigated levels of antibody Metrics mRNA mRNA vaccines Multivariable models nervous system neutralizing antibody Neutralizing antibody response participant Pfizer-BioNTech physiological pre-vaccination predictor RBD reported response responses Ring second significantly skin temperature Sleep statistically temperature the SARS-CoV-2 vaccination Vaccines Variability wearable devices [DOI] 10.3390/vaccines10020264 PMC 바로가기 [Article Type] Article
Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients임상 및 항체 특성은 중증 및 비중증 SARS-CoV-2 환자의 다양한 특징을 나타냅니다.Research Article Published on 2022-02-022022-09-10 Journal: Infectious Diseases of Poverty [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 adenosine adenosine deaminase analyzed antibodies antibody Antibody detection Antibody Response Antibody responses benefit bile acid binding C-reactive protein Characteristics clinical Clinical features clinical information collected contribute correlated COVID-19 COVID-19 case COVID-19 pandemic COVID-19 patient CTD cytokine Cytokines D-dimer domain domains elevated FcγRIIb Fisher’s exact test future therapeutic Ig isotypes IgG subclasses IgG1 IgG3 IL-6 IL-8 immune response investigated IP-10 LDH lymphocyte Lymphocyte count Mann–Whitney U test MCP-1 MCP-3 MIG neutrophil neutrophil count non-severe group NTD Patient patients preventive measure preventive measures procalcitonin Prognosis provide RBD RBD-ACE2 RBM receptors Result SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 spike protein serum sample serum samples severe group Severe patient significantly specificity Spike protein supplementary material Treatment [DOI] 10.1186/s40249-022-00940-w PMC 바로가기 [Article Type] Research Article
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen스파이크 기반 COVID-19 면역은 뉴클레오캡시드 항원에 대한 항체를 증가시킵니다Article Published on 2022-02-012022-09-11 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] antibody Antibody Response Antibody responses Antigen avidity BNT162b2 C-terminus COVID-19 COVID-19 vaccination cross-reactive antibodies cross-reactive antibody detect full length Health care health care workers IgA IgG level IgG levels immunization immunoassay immunogenicity increase increase in individuals Infection MONITOR mRNA mRNA-1273 multiplex N antigen nucleocapsid nucleocapsid antigen Protein S-based vaccines SARS-CoV-2 S Seropositivity Subunit vaccine subunit vaccines suggested the SARS-CoV-2 vaccination Vaccine [DOI] 10.1016/j.trsl.2021.10.004 PMC 바로가기 [Article Type] Article
Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers일본 인구에서 SARS-CoV2 감염에 대한 다양한 종류의 항체 반응 역학: IgA 및 IgG 역가가 IgM 역가보다 일찍 증가했습니다.Article Published on 2022-02-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody responses Asian association Clinical course clinical feature Clinical features coronavirus COVID-19 domain IgA IgA antibodies IgA antibody IgG IgG response IgG responses IgG titer IgM IgM and IgG IgM responses IgM seroconversion IgM/IgG immune response immune responses individuals with COVID-19 Infection Japanese Japanese population Kinetics Kinetics of antibody responses less Mild nucleocapsid protein occurred Patient Population populations Protein RBD Receptor-binding domain respiratory response S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV2 infection Seroconversion serum titer serum titers severe acute respiratory syndrome Coronavirus spike Spike protein spread of COVID-19 sustained the antibody response the S1 subunit the spike protein timeline Viral protein Viral proteins [DOI] 10.1016/j.intimp.2021.108491 PMC 바로가기 [Article Type] Article
Long-Term Kinetics of SARS-CoV-2 Antibodies and Impact of Inactivated Vaccine on SARS-CoV-2 Antibodies Based on a COVID-19 Patients CohortCOVID-19 환자 코호트를 기반으로 한 SARS-CoV-2 항체의 장기 동역학 및 비활성화된 백신이 SARS-CoV-2 항체에 미치는 영향Immunology Published on 2022-01-272022-09-12 Journal: Frontiers in Immunology [Category] 진단, [키워드] antibody Antibody responses antibody titres blood sample boost Characteristics chemiluminescence China Cohort collected convalescent patient Convalescent patients COVID-19 demographics dose enrolled enzyme epidemiological data follow-up time IgG IgG antibody IgG level IgM immunoassay Impact Inactivated vaccine individuals information IQR Jiangsu kinetic Kinetics long-term kinetics majority median natural infection Neutralizing antibodies neutralizing antibody participant Patient populations positive remained Result RT-PCR SARS-CoV-2 SARS-CoV-2 antibody significantly higher single dose symptom onset tested understanding vaccinated individual vaccination Vaccination strategy [DOI] 10.3389/fimmu.2022.829665 PMC 바로가기 [Article Type] Immunology
Limited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein스파이크 당단백질에 대한 항체 반응의 도메인 특이성과 상대적 효능에서 SARS-CoV-2 감염 개인 간의 제한된 변이Research Article Published on 2022-01-262022-09-12 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity analyzed anti-spike antibodies anti-spike antibody antibodies antibody Antibody neutralization Antibody Response Antibody responses antiviral activity caused characterized collected composed convalescent convalescent-phase plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine defined domain domains Efficacy elicit elicited exhibited fixed form generate immunoassay immunoglobulins individual infected individual Limited MOST N-terminal domain neutralization neutralization potency neutralize Neutralizing activity Neutralizing antibodies NTD pandemic plasma samples polyclonal potency produced Protective pseudovirus quantity RBD Receptor-binding domain Region relative replication-competent SARS-CoV-2 response Sample SARS-CoV-2 SARS-CoV-2 spike serum serum and plasma Seven severe acute respiratory syndrome Coronavirus specificity spike glycoprotein Spike protein subject subjects subunit subunits tested the antibodies the antibody the antibody response the RBD the receptor-binding domain the Spike the spike protein trimer vaccinated individual Variability Variation virus while [DOI] 10.1128/spectrum.02676-21 PMC 바로가기 [Article Type] Research Article