A bilirubin-derived nanomedicine attenuates the pathological cascade of pulmonary fibrosis빌리루빈 유래 나노의약은 폐 섬유증의 병리학적 캐스케이드를 약화시킵니다Article Published on 2021-08-012022-09-11 Journal: Biomaterials [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory Anti-inflammatory effects antioxidant antioxidants Antioxidative ARDS attenuate bile acid Bilirubin Bilirubin nanoparticles Biomarkers Bleomycin blood circulation cascade caused Clinical sign Clinical signs COVID-19 COVID-19 infection disease fibrosis histological Immune cell immune cells incidence life-threatening mice nanomedicine outbreak oxidative damage pulmonary pulmonary fibrosis reduce respiratory distress SARS-CoV-2 SARS-COV-2 infection shown syndrome the disease therapeutic options therapeutic potential [DOI] 10.1016/j.biomaterials.2021.120986 PMC 바로가기 [Article Type] Article
FIP200 restricts RNA virus infection by facilitating RIG-I activationArticle Published on 2021-07-292022-10-31 Journal: Communications Biology [Category] Coronavirus, [키워드] Activation cascade caspase deficiency demonstrated domain expression facilitate facilitated Helicase host susceptibility induce Infection innate immune innate immune response interact Interaction knockout mice mechanism oligomerization pathway Protein recruitment reduced regulate Regulatory restrict RIG-I RIG-I-like receptors RNA RNA virus Signaling signaling molecule susceptible type I interferon Viral RNA Virus-host interactions [DOI] 10.1038/s42003-021-02450-1 PMC 바로가기 [Article Type] Article
Cerebral Venous Sinus Thrombosis as an Unexpected Complication of COVID-19 PneumoniaInternal Medicine Published on 2021-07-192022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress Angiotensin-converting enzyme anticoagulation Atypical cascade cerebral cerebral venous sinus thrombosis Complication Coronavirus disease 2019 COVID 19 COVID-19 COVID-19 disease endothelial damage highlight hypercoagulability lung tissue pathogenesis of COVID-19 patient with COVID-19 prevalent renal injuries sagittal sinus thrombosis SARS-CoV-2 Sinus syndrome target the cytokine storm therapeutic anticoagulation Thromboembolic event thrombosis treatable Trigger Vascular endothelium venous viral infection [DOI] 10.7759/cureus.16498 PMC 바로가기 [Article Type] Internal Medicine
Hepatitis C Diagnosis: Simplified Solutions, Predictive Barriers, and Future PromisesReview Published on 2021-07-132022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Algorithm Analysis approval assays Blood Care cascade clinical experience country Diagnosis diagnostic dried blood spot Future HCV HCV core antigen HCV elimination Health Hepatitis hepatitis C hepatitis C diagnosis hepatitis C-self testing highlight identify individuals measure modulating Nucleic acid amplification technologies one-step screening overcome platform POC point-of-care test Population promise public health Rapid diagnostic test Rapid diagnostic tests reflex RNA testing RNA Treatment WHO’ [DOI] 10.3390/diagnostics11071253 PMC 바로가기 [Article Type] Review
Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia뚜렷한 면역학적 특징은 심각한 COVID-19를 SARS-CoV-2에 의해 유발되지 않은 치명적인 폐렴과 구별합니다.Comparative Study Published on 2021-07-132022-09-11 Journal: Immunity [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, [키워드] adaptive alteration Analysis binding Biomarker cascade Cell change circulating ClinicalTrials COVID-19 COVID-19 patient Critical Cytometry driven by feature flow cytometry Frequency GM-CSF high-dimensional single cell analysis HLA HLA typing ICU patient ICU Patients immune Immune profile immune profiling immune signature Immunity immunological immunopathology Immunophenotyping Inflammatory response integration interfere longitudinal NKT outcome paralysis Patient peptide peptide binding strength peptides Pneumonia predicted Predictive SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides severe COVID-19 Single Cell single-cell spectral flow cytometry. T cell the patient translation Treatment strategies treatment strategy virus recognition [DOI] 10.1016/j.immuni.2021.05.002 PMC 바로가기 [Article Type] Comparative Study
Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast CellsReview Published on 2021-07-122022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] adjuvant antiviral immune response Autopsy cascade Cell coronavirus disease COVID-19 COVID-19 vaccine cytokine cytokine response Cytokine storm Cytokine storm syndrome died distress Evidence function immune response immune system Impact Inflammation lung mast cell Mast cells medication Organ failure Patient Pulmonary edema Recognition reduce role SARS-CoV-2 severity of COVID-19 storm syndrome the cytokine storm thought thrombosis Treatment Vaccine virus [DOI] 10.3390/cells10071761 PMC 바로가기 [Article Type] Review
Socioeconomic position and the COVID-19 care cascade from testing to mortality in Switzerland: a population-based analysisArticles Published on 2021-07-102022-10-29 Journal: The Lancet. Public Health [Category] COVID-19, [키워드] adjusted Admission affected age analysed Analysis association binomial regression model calculate Care cascade country COVID-19 COVID-19 epidemic COVID-19 vaccination CrI death deaths decile defined finding foundation funding Gap General population group Health health-care system heterogeneity highest Horizon hospital hospitalisation hospitalisations ICU ICU admission ICU admissions identify incidence rate infection control intensive care interval less lowest measure Model MONITOR Mortality office outcome outcomes pandemic Population positive Public receive reduce reported SARS-CoV-2 Science Sex surveillance data Switzerland tested the epidemic the SARS-CoV-2 [DOI] 10.1016/S2468-2667(21)00160-2 PMC 바로가기 [Article Type] Articles
An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune systemReview Published on 2021-07-092022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] Abstract acute respiratory syndrome addressed angiotensin-converting enzyme 2 antiviral drugs Antiviral treatment cascade caused complement coronavirus disease coronavirus disease 19 COVID-19 develop disease disease severity effective vaccine highlight Host Host immune response immune system Infection information Interaction intervals Novel coronavirus outbreak overactive PAMPs pathophysiological physical distancing PROTECT PRR reduce Research SARS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 transmission Spread Still Support Therapeutic molecule Transmission Vaccine viral infection virus virus infection washing hand Wuhan, China [DOI] 10.1186/s42269-021-00582-2 PMC 바로가기 [Article Type] Review
Isolation of SARS-CoV-2 from the air in a car driven by a COVID patient with mild illness가벼운 질병을 가진 COVID 환자가 운전하는 자동차의 공기에서 SARS-CoV-2의 격리Article Published on 2021-07-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] air conditioning cascade completion cough COVID COVID-19 patient detectable determine drive driven by Fever highlight infected with SARS-CoV-2 Mask mild illness Particle Particles Patient PCR potential risk retrieved risk SARS-CoV-2 SARS-CoV-2 aerosols SARS-CoV-2 in vehicles. SARS-CoV-2 transmission Section Stage symptomatic virus windows [DOI] 10.1016/j.ijid.2021.04.063 PMC 바로가기 [Article Type] Article
Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom영국에서 COVID-19 전염병 동안 백신 시험을 수행하기 위한 도전과 기회Design Published on 2021-06-222022-09-11 Journal: Clinical Trials (London, England) [Category] MERS, 임상, [키워드] assessment procedures best Cambridgeshire cascade challenge clinical trial clinical trials coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine diagnostics Healthcare system Healthcare systems identify Infectious disease information information technology National Health Service pandemic participant Patient public health emergency recruit Research SARS-CoV-2 stimulated structures teleconference Trial Trust United Kingdom vaccinate Vaccine Vaccine development vaccine trial [DOI] 10.1177/17407745211024764 PMC 바로가기 [Article Type] Design