Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans인간 곰팡이 병원체 Cryptococcus neoformans에서 Ras1, Cdc24 및 Ptp3의 고유한 역할을 통한 저산소 반응의 분자 메커니즘Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin affected Analysis biological processe biological processes C. neoforman C. neoformans CAMP caused Cdc42 central gene chromosome Compound Concentration condition conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoskeletal Deletion downstream eight ergosterol eukaryotic cells expression of gene family function fungal genes encoding genetic analysis genotoxic growth growth defect growth retardation GTPase guanine Human human host hypoxia hypoxic hypoxic condition hypoxic conditions indicated inhibit inhibitor involved maintenance molecular mutant not affected nucleotide osmotic oxygen pathogen pathway Pathways phosphatase phosphatases Phosphorylation Protein protein translation Rac1 Rac2 regulate required rescued response Rho GTPase RNA RNA sequencing role sequence similarity single cells strain Strains suggested suppressor These cells Tolerance unique wild-type strain [DOI] 10.1371/journal.pgen.1004292 PMC 바로가기 [Article Type] Research Article
A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness관련성 전체 스펙트럼에 걸친 일배체형 단계에 대한 일반적인 접근 방식Research Article Published on 2014-04-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy allele alleles approach association can be used chance chromosome Cohort cohorts correction detect disease downstream analyses error rate explicit Genetic Genetic studies genetics Genotype genotyped individuals genotypes genotyping Haplotype haplotypes IBD individual individuals information investigated isolates Merlin much lower parents Phenotypes Population populations provide Recombination recombination event researcher sequence Spectrum [DOI] 10.1371/journal.pgen.1004234 PMC 바로가기 [Article Type] Research Article
Molecular Characterizations of Subcellular Localization Signals in the Nucleocapsid Protein of Porcine Epidemic Diarrhea VirusArticle Published on 2014-03-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid antibiotic Cell cellular characterization chromosome CHROMOSOME region maintenance 1 confocal microscopy coronavirus Critical cytoplasm epidemic diarrhea eukaryotic fluorescent full-length functional fusion protein GFP Infection inhibited Localization Mutation N protein NES nuclear nuclear export signal nucleocapsid nucleocapsid protein Nucleolus pathway PEDV Porcine epidemic diarrhea virus Protein signal site-directed mutagenesis subcellular localization signals the N protein VERO E6 cells virus virus replication [DOI] 10.3390/v6031253 PMC 바로가기 [Article Type] Article
Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and FunctionSUN1 결핍 마우스의 감수분열 분석은 포유류 감수분열 LINC 복합체 형성 및 기능에서 SUN2의 뚜렷한 역할을 보여줍니다Research Article Published on 2014-02-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence appear attachment cause chromosome Clusters complexes component composed conserved Critical Deficient demonstrated described detect determine domain driving error event expressed Formation function functional functions Genome homolog indicate infertility interfere KASH5 lead meiosis meiotic meiotic recombination membrane mice nuclear nuclear envelope prophase Protein protein complex protein complexes Proteins provoke recent Recombination regulated retained role shown subsequent SUN1 SUN2 telomere telomeres while [DOI] 10.1371/journal.pgen.1004099 PMC 바로가기 [Article Type] Research Article
Chromosomal Copy Number Variation, Selection and Uneven Rates of Recombination Reveal Cryptic Genome Diversity Linked to Pathogenicity염색체 복사 수 변이, 선택 및 재조합의 불균등한 비율은 병원성과 관련된 비밀 게놈 다양성을 나타냅니다Research Article Published on 2013-08-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive addition Analysis asexual association Author Batrachochytrium dendrobatidis change changes in characterized chromosomal chromosome contribute contributed copy copy number Culture de novo directional Diversity ecological niche ecological niches effort Evidence evidence of Evolution explain Factors feature fungal fungi Gene Genetic Genome genomes growth Host hot spots in vitro infect isolate knowledge Lineage lineages majority manifested mechanism microbial number occur organism pathogen pathogenicity Pathogens phenotypic ploidy Rate Recombination Region replicate reported reproduction response Secretome Selection sequenced target Transmission Variability Variation virulence virulence factors widespread [DOI] 10.1371/journal.pgen.1003703 PMC 바로가기 [Article Type] Research Article
Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8 , as a Genetic Component of Neural Tube Defects in Humans개의 게놈 전반에 걸친 연관 매핑을 통해 인간의 신경관 결함의 유전적 구성 요소인 호메오박스 유전자 NKX2-8 식별 가능Research Article Published on 2013-07-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition affected Analysis animal animal models Author birth defects Brain canine Care caused Central nervous system chromosome closure codon Combination comparable complex component condition contribute costly defect develop disease dog during pregnancy dysraphism embryonic ENCODE environmental factors etiology Evidence ExoN exons expected explain expressed failure found frameshift frameshift mutation general term Genes Genetic Genetic studies genetics Genome genome-wide association genomic region home environment Homeobox Human human population human populations humans identification identify in addition to interactions lead malformation mapped mapping mechanism Medical care molecular basis morbidity and mortality multifactorial Mutation Neural neural tube Neural tube defect Neural tube defects NKX2 NKX2-8 NTD NTDs occur pathology Patient performed predicted Pregnancy premature stop codon Protein rare variant Rare variants receive Regulatory regulatory gene reported resulting secondary to sequenced Sequencing significantly skin Soft tissue spina bifida spinal cord spinal dysraphism Structure Taking tissue tissues tube vertebral column Weimaraner [DOI] 10.1371/journal.pgen.1003646 PMC 바로가기 [Article Type] Research Article
Genome-Wide Analysis in German Shepherd Dogs Reveals Association of a Locus on CFA 27 with Atopic DermatitisGerman Shepherd Dogs의 게놈 전체 분석을 통해 아토피 피부염과 CFA 27에 대한 유전자좌 연관성 밝혀Research Article Published on 2013-05-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition affected age allergic skin Analysis association atopic dermatitis Author block blocks CAD canine caused CFA chromosome Cohort compared complex contributing to Control correlation defined dermatitis detected develop different disease Disease prevalence division dog eight environmental factors expressed found Genes Genetic genetics Genome genome-wide association genome-wide significant genotyping German shepherd GSD Haplotype high correlation Human IgA level IgA levels included indicate Interaction mixed model approach parameters performed PKP2 plakophilin population stratification Prevalence sampling separation Sequencing serum significantly significantly lower skin disease SNPs study population subpopulation subpopulations subset Swedish the strongest was performed was used [DOI] 10.1371/journal.pgen.1003475 PMC 바로가기 [Article Type] Research Article
The Tomato Yellow Leaf Curl Virus Resistance Genes Ty-1 and Ty-3 Are Allelic and Code for DFDGD-Class RNA–Dependent RNA Polymerases토마토 황엽말림 바이러스 내성 유전자 Ty-1 및 Ty-3은 대립유전자이고 DFDGD-Class RNA-Dependent RNA 중합효소에 대한 코드입니다Research Article Published on 2013-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles allelic amplification approach atypical DFDGD motif Author begomovirus begomovirus species Breeding catalytic DLDGD motif catalytic domain cause caused characterized chromosomal region chromosome chromosome 6 class code Combination described different disease geminivirus geminiviruses Gene gene functions genomic region inbred lines induced introgression leaf mapped marker mechanism molecular molecular markers Multiple plant plants RDR RDRα RDRα type RDRγ recent finding recent findings recombinant inbred lines recombination event Region related resistance resistance gene resistance genes resistance mechanism RNA RNA–dependent RNA polymerase shown Solanum chilense Solanum chilense –derived Ty-1 and Ty-3 genes specificity subtropical susceptible these viruses Tobacco Tobacco Rattle Virus tomato Tomato yellow leaf curl virus Tomato Yellow Leaf Curl Virus Disease transcriptional tropical Ty-1 Ty-1 and Ty-3 Ty-1/Ty-3 gene Ty-3 TYLCV virus Virus Disease viruses yellow [DOI] 10.1371/journal.pgen.1003399 PMC 바로가기 [Article Type] Research Article
ImmunoChip Study Implicates Antigen Presentation to T Cells in NarcolepsyImmunoChip 연구는 기면증에서 T 세포에 대한 항원 제시를 의미합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Alpha Antigen presentation antigen processing Author Autoimmune autoimmune and inflammatory diseases autoimmune attack Autoimmune disease Cathepsin H chromosome chromosome 6 class compared Consensus Control controls CTSH deficiency disease pathogenesis disease risk encoded protein encoded proteins environmental exposure European Gene Genes genome-wide significance genotyped genotyping high-density genotyping platform HLA HLA class II HLA DQB1*06:02 Human human leukocyte antigen hypocretin cells ImmunoChip immunological synapse implicated in addition to individual inflammatory disease Inflammatory diseases Interaction leukocyte Ligand loci mechanism Narcolepsy narcolepsy-hypocretin deficiency OX40L pathophysiology pathway post-infectious autoimmune presentation progression recent selective significantly study variant Support susceptibility T cell T cell receptor T cell response T cells the disease TNFSF4 TNFSF4/OX40L tumor necrosis tumor necrosis factor unique variant variants while [DOI] 10.1371/journal.pgen.1003270 PMC 바로가기 [Article Type] Research Article
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen FamiliesPlasmodium falciparum의 유사분열 진화는 안정적인 핵심 게놈을 보여주지만 항원 가족에서 재조합을 보여줍니다Research Article Published on 2013-02-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] absence allele amplification Analysis anti-malarial drug Anti-malarial drugs antigenic variation atovaquone Author average base pair change chromosomal crossover chromosomal crossovers chromosome chromosome 1 clone clones Combination Complete core core genome cytochrome b death Deletion determined develop different disease drug drug pressure drug resistance drug target effort evade event Evolution family FIVE found Frequency Gene gene families genetic change Genetic changes Genome genomic alteration global health Haplotype Health help Host Host immune response host immune responses human host immune evasion immune resistance immune response immune responses IMPROVE in vitro increase individual level Infectious disease initiated involved malaria malaria parasites microarray technique mitosis mitotic mitotic recombination mrp1 Multidrug resistance multigene families multigene family Mutation mutation rate Mutation rates natural infection nucleotide occur P. falciparum parasite parasites Plasmodium Plasmodium falciparum plasticity populations presence or absence Protein Recombination recombination event Region responsible sequence variability show Single nucleotide variant single nucleotide variants STABLE strain Structural variant structural variants subtelomeric region subtelomeric regions var gene family whole-genome microarray whole-genome sequencing [DOI] 10.1371/journal.pgen.1003293 PMC 바로가기 [Article Type] Research Article