Digitalization of presence events in the COVID-19 pandemia – the lecturers’ perspectiveArticle Published on 2021-01-282022-11-01 Journal: GMS Journal for Medical Education [Category] Coronavirus, [키워드] ad-hoc anticipated asked category change changes conducted Course COVID-19 COVID-19 pandemic described developmental Digitalization Disadvantages disease Effect event faculty lack Magdeburg online courses Pandemia pandemic Perspective replaced subject teacher Teaching university [DOI] 10.3205/zma001426 PMC 바로가기 [Article Type] Article
Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cellsArticle Published on 2021-01-282022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] addition Analysis Astrocyte Cell cells cholesterol develop developmental Developmental neurogenesis differentially expressed gene disease driven by embryonic facilitate Genome heterogeneity identify identity IMPROVE include Intervention involved Lineage lineages maturation molecular multiple sclerosis Oligodendrocyte pathway Pathway enrichment analysis PDGFRα pharmacological pluripotent stem cells predict progenitor cell promoter purification Regulatory reporter reporter cell reveal RNA sequencing RNA-sequencing signaling pathway Single Cell subset trajectory transcriptional transcriptomic Treatment strategies [DOI] 10.1038/s41467-021-20892-3 PMC 바로가기 [Article Type] Article
Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike ProteinReview Published on 2021-01-202022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] ACE2 activate Activation aggregation Alternative pathway alveolar cell Amino acid amplify Angiogenesis B.1.1.7 binding Biological Blood Cell cell entry clinical Coagulation consequence Consequences contribute COVID-19 developmental domain dysregulation endothelial Endothelial cell ENhance enzyme Factor Factors high variability Host Hypothesis Impact impacts in viral include independent integrin integrin-mediated integrin-mediated signaling Integrins Interaction microthrombi modulated motif Mutation N501Y Numerous pathway Pathways Platelet Platelets Pneumocytes procoagulant receptor Receptor-binding domain resulting RGD motif SARS CoV-2 sequence Signaling signaling pathway spike Spike protein strain stroke suggested susceptibility the receptor-binding domain the SARS-CoV-2 virus the spike protein thrombosis thrombotic tissue tissue damage tissue microenvironment variant viral entry virion virion binding virus widespread [DOI] 10.3390/v13020146 PMC 바로가기 [Article Type] Review
The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus MonkeysGenetics Published on 2021-01-182022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Analysis analyzed animal model association Brain BSG children coronavirus coronavirus 2 coronavirus disease correlated COVID-19 CTSB CTSL development developmental differential expression DPP4 dynamic endosomal protease evaluate exhibited expressed expression expression level feature help highest Immune cell infiltration Immunity incidence Infection livers lung Lungs mediator Mild moderate Monkey Neonate Neonates Other pandemic pathogenic Population populations Potential protease Protective reached receptor researcher respiratory Rhesus monkey SARS-CoV-2 SARS-CoV-2 receptor severe disease Spread stages susceptibility therapeutic strategy TMPRSS2 TMPRSS9 Transcriptome transmembrane serine protease TTSPs Type Variability [DOI] 10.3389/fgene.2020.607479 PMC 바로가기 [Article Type] Genetics
An evaluation of COVID-19 transmission control in Wenzhou using a modified SEIR modelOriginal Paper Published on 2021-01-082022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, [키워드] added analysed average Baidu calculated caused changes in Characteristics Commission Contact Contact tracing Coronavirus disease 2019 COVID-19 COVID-19 transmission cured death developmental Efficiency Emergency Emerging infectious disease Epidemic epidemiological Factors Health hospitalisation hypothetical implementation initial intensity lockdown measure Novel coronavirus number of infected outbreak pandemic parameter platform Pneumonia populations preventive measures Public recommendation reported SEIR SEIR modelling sensitivity social distancing social distancing measures Spread spread of COVID-19 symptom onset the epidemic Travel virus transmission simulation Wuhan [DOI] 10.1017/S0950268820003064 PMC 바로가기 [Article Type] Original Paper
Human stem cell models to study host–virus interactions in the central nervous system Reviews Published on 2021-01-042022-10-05 Journal: Nature reviews. Immunology [Category] SARS, 신약개발, 치료제, [키워드] acute infection acute respiratory syndrome advancement Affect antiviral immunity Brain brain development caused Cell cell type Central nervous system clinical outcomes CNS complex coronavirus determine developmental disease Encephalitis Genetic herpesviruses host–virus interaction Human latency mechanisms molecular mechanism neurological neurotropic offer prenatal question restriction factor SARS-CoV-2 stages subpopulation susceptibility unique virus [DOI] 10.1038/s41577-020-00474-y [Article Type] Reviews
Clinical analysis and pluripotent stem cells-based model reveal possible impacts of ACE2 and lung progenitor cells on infants vulnerable to COVID-19임상 분석 및 만능 줄기 세포 기반 모델은 COVID-19에 취약한 유아에 대한 ACE2 및 폐 전구 세포의 가능한 영향을 보여줍니다Multicenter Study Published on 2021-01-012022-09-01 Journal: Theranostics [Category] 진단, 치료기술, [키워드] ACE2 ACE2 expression age Alveolar Type II analysed Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsies Cell cells children children with COVID-19 clinical clinical feature Clinical features Cohort Combination contributing to cooperation coronavirus disease Coronavirus disease 2019 COVID-19 derivative develop developmental developmental stages disease severity distribution double positive cell double positive cells Ex vivo examined expressed expression expression level expression levels expression pattern expression patterns immune response immune system Impact Infant Infants infections lung lung biopsies lung cell lung cells lung development lung injuries Lung injury lung progenitor cells Lungs number of children Older pluripotent stem cells Pneumonia positive profiles progenitor cell progenitor cells reported risk factor Risk factors RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 virus severe coronavirus disease significantly single cell RNA sequencing SOX9 Spectrum Stage stem cell Type vulnerability with COVID-19 [DOI] 10.7150/thno.53136 PMC 바로가기 [Article Type] Multicenter Study
Microstructure, pathophysiology, and potential therapeutics of COVID-19: A comprehensive reviewCOVID-19의 미세구조, 병태생리학 및 잠재적 치료제: 종합 검토Review Published on 2021-01-012022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] 2019-nCoV 2019-nCoV infection ACE2 Affect against SARS-CoV Analysis angiotensin-converting enzyme 2 Antigen coronavirus COVID-19 cross-reactivity death developmental Diagnosis diagnosis of COVID-19 diagnostic disease domain drug Genetic variation genomic gold standard help higher risk HLA host-pathogen interaction individual Infection infections initial leukocyte MERS-CoV Microstructure Morphological Novel coronavirus pathophysiology polymerase chain RBD SARS-CoV sequence similarity serological test Seven severity spread of COVID-19 Stage the antibody the spike protein Trial understanding Vaccine vaccine candidate Variation virus whole protein [DOI] 10.1002/jmv.26254 PMC 바로가기 [Article Type] Review
Measuring the Outcomes of Maternal COVID-19-related Prenatal Exposure (MOM-COPE): study protocol for a multicentric longitudinal project산모의 COVID-19 관련 산전 노출 결과 측정(MOM-COPE): 다심적 종단 프로젝트를 위한 연구 프로토콜Article Published on 2020-12-312022-09-11 Journal: BMJ Open [Category] SARS, 유전자 메커니즘, [키워드] approved association behavioural Birth Cohort collected conception contribute coping strategies COVID-19 Critical depressive developmental DNA methylation during pregnancy Effect enrolled Epidemic Epigenetic Ethics ethics committee Europe exposure exposure to Health hotspot Infant Infants infection rate Interaction International Italy Maternal mechanism Mental mental health methodological Methylation mother National outcomes Pavia peer-reviewed perinatology Pregnancy prenatal programming protocol Psychological psychological status Psychological stress registration number Regulation respiratory Respiratory disease Result retrospective retrospective data risk saliva sample saliva samples sensitivity Spread Stress Study protocol Symptoms virus [DOI] 10.1136/bmjopen-2020-044585 PMC 바로가기 [Article Type] Article
Postpartum mood among universally screened high and low socioeconomic status patients during COVID-19 social restrictions in New York CityArticle Published on 2020-12-242022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] assist childbearing coronavirus 2 COVID-19 Depression developmental disorder Edinburgh Effect emotional Environmental social sciences Health Health care implication investigated less mental health mental illness morbidity Mount Sinai New York City no difference offspring outcome pandemic Patient poor mental health Postpartum Postpartum depression practitioners Pregnancy prevalent Psychology respiratory Risk factors SARS-CoV-2 scale screened significantly Support System unique was determined while women [DOI] 10.1038/s41598-020-79564-9 PMC 바로가기 [Article Type] Article