Development and characterization of anti-SARS-CoV-2 intravenous immunoglobulin from COVID-19 convalescent plasmaArticle Published on 2022-10-012022-11-15 Journal: Immunotherapy [Category] COVID19(2023년), SARS, 진단, [키워드] administration Adults allergenic animal models anti-SARS-CoV-2 clinical trial Concentration convalescent plasma COVID-19 COVID-globulin development developmental Efficacy hamster healthy hyperimmune hyperimmune immunoglobulin IgG Immunoglobulin immunoglobulin against COVID-19 Immunosuppressed inactivation intravenous Intravenous immunoglobulin investigated material Neutralizing plasma preclinical evaluation produced Protective protective efficacy Protein purification Safe Safety SARS-CoV-2 SARS-CoV-2 neutralizing antibody Toxicity virus [DOI] 10.2217/imt-2022-0015 PMC 바로가기
A key F27I substitution within HCDR1 facilitates the rapid maturation of P2C-1F11-like neutralizing antibodies in a SARS-CoV-2-infected donorArticle Published on 2022-09-132022-11-15 Journal: Cell Reports [Category] SARS, 진단, [키워드] Analysis anti-SARS-CoV-2 antibodies antibody antibody repertoire Bioactivity characterized contribute CP: Immunology deep sequencing developmental Donor early infection elicit event facilitate immunogen information Lineage longitudinal maturation monoclonal NAb neutralizing antibody P2C-1F11 lineage pathway reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibody sequence significantly viral infection [DOI] 10.1016/j.celrep.2022.111335 PMC 바로가기
Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and FunctionalityArticle Published on 2022-09-042022-11-15 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish [DOI] 10.3390/ijms231710130 PMC 바로가기
Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2020 and 2021.Research article Published on 2022-09-012022-10-05 Journal: Reproductive toxicology (Elmsford, N.Y.) [Category] 비임상, [키워드] adopted adverse effect approvals approved clinician conducted developmental drug drugs FDA information majority monoclonal antibody non-human primate performed Pregnancy recommendation review risk rodent rule tested therapeutic Toxicity while [DOI] 10.1016/j.reprotox.2022.06.012 [Article Type] Research article
Improving child health through Big Data and data science Reviews Published on 2022-08-162022-10-05 Journal: Pediatric Research [Category] 바이오마커, [키워드] assessments Characteristics child health childhood children complex creating defined determinant developmental dimension disease risk Diseases fetal for inclusion Genetic Health highlight identify Impact IMPROVE Improving infancy Interaction mechanisms outcomes Patient pediatric phenotype Predictive provide Racial recommendation reducing Regulatory Research resource susceptibility the United State Therapies Trajectories while [DOI] 10.1038/s41390-022-02264-9 [Article Type] Reviews
Environmental influences on child health outcomes: cohorts of individuals born very preterm Reviews Published on 2022-08-102022-10-05 Journal: Pediatric Research [Category] 바이오마커, [키워드] Asthma can be used characterized Child Cohort complications condition developmental disorders Effect enrolled environmental exposure environmental factor Extensive Health hypothese Impact increased risk individual influence influences on mechanism obesity outcome outcomes positive Preterm birth Program provided question Research Research question risk social determinant study participant [DOI] 10.1038/s41390-022-02230-5 [Article Type] Reviews
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacyReview article Published on 2022-08-012022-10-05 Journal: Translational research : the journal of laboratory [Category] SARS, 변종, 임상, [키워드] ACE2angiotensin-converting enzyme 2 acute respiratory distress syndrome addressed angiotensin-converting enzyme 2 ARDSacute respiratory distress syndrome cells Characteristics clinical trials complications COVID-19 COVID-19 pandemic developmental effective Effectiveness Efficacy Entry mechanism feature genomic growth highlight Immune escape immune response increased risk indicate individual investigated mechanism mechanisms mRNA-based COVID-19 vaccine Neonates pathology placental Pregnancy pregnant Preterm birth proteomic RASRenin-angiotensin system renin-angiotensin system risk SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2severe acute respiratory syndrome coronavirus-2 severe acute respiratory syndrome coronavirus-2 Stillbirth the vaccine Transmissibility Vaccine Vaccines variants of concern variants of SARS-CoV-2 vector VOCvariants of concern [DOI] 10.1016/j.trsl.2022.08.007 [Article Type] Review article
Metabolic signatures in human follicular fluid identify lysophosphatidylcholine as a predictor of follicular development Research Published on 2022-07-292022-10-05 Journal: Communications Biology [Category] 바이오마커, [키워드] analyzed Biomarker Blood can be used Characteristics clinical implications described developmental first stage follicular Follicular fluid Health humans identify immunoassay improvement independent knowledge lysophosphatidylcholine metabolic metabolomic metabolomics Oocyte ovarian participant Participants Potential biomarker predictor Regulation sensitivity serum stages Study design therapeutic target transcriptomic data [DOI] 10.1038/s42003-022-03710-4 [Article Type] Research
The Chilean Maternal-Infant Cohort Study-II in the COVID-19 Era: A Study ProtocolArticle Published on 2022-07-142022-10-05 Journal: Frontiers in Public Health [Category] 임상, [키워드] age assessment association biochemical Breast Chilean clinical Cohort collected concentrations consequence COVID-19 COVID-19 pandemic Critical developmental dietary intake gestation Glucose growth growth factor Health hemoglobin Infant infant growth infant health infant nutrition information insulin lactation Maternal Maternal Health Mental mental health mental health problem mother Neonatal nutrition nutritional status Observatory Obstetric offspring Pregnancy pregnant women preliminary finding public health measure public health system recruited recruitment Trial [DOI] 10.3389/fpubh.2022.904668 PMC 바로가기 [Article Type] Article
A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys Research Published on 2022-07-132022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Analysis animal model Cell cell type cellular cellular processes chromatin developmental element feature gene expression pattern gene regulatory network heterogeneity humans identify Laboratory molecular multiple organ multiple tissue Non-human non-human primate organ-specific organs provide RNA sequencing data similarity single-cell single-cell level trajectory transcriptomic transcriptomic data valuable resource [DOI] 10.1038/s41467-022-31770-x [Article Type] Research