Repurposing proteases: An in-silico analysis of the binding potential of extracellular fungal proteases with selected viral proteinsResearch article Published on 2021-09-012022-10-05 Journal: Bioresource Technology Reports [Category] 신약개발, [키워드] Analysis Antiviral binding binding energy COVID degrade docking drugs enzyme Enzymes Extracellular fungal identify in-silico infectious agents microbial Penicillium protease Protein repurposing resource selected tap the SARS-CoV-2 virus therapeutic therapeutic agent Viral protein viral spike [DOI] 10.1016/j.biteb.2021.100756 [Article Type] Research article
Association Between S100b Levels and COVID-19 Pneumonia: A Case Control StudyS100b 수준과 COVID-19 폐렴 간의 연관성: 사례 대조 연구Article Published on 2021-09-012022-09-11 Journal: In vivo (Athens, Greece) [Category] SARS, 바이오마커, [키워드] addition Admission alveolar Analysis association AUC Blood Cell cell surface molecule Clinical severity Cohort Concentration Control COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient COVID-19 patients COVID-19 pneumonia diagnosed with COVID-19 Diagnosis disease during admission Effect emergency department end products expressed Extracellular greater healthy control healthy controls healthy volunteer immunoassay Immunoglobulin indicated Level marker mean value membrane Mild multiligand receptor parameters Patient patients Pneumonia predict protein level RAGE receiver operating characteristic receptor receptor for advanced glycation end products ROC S100B S100b levels sensitivity serum serum samples severe cases severe disease severity of COVID-19 significantly higher specificity Stage tissue type I was measured were measured [DOI] 10.21873/invivo.12583 PMC 바로가기 [Article Type] Article
Treatment of a COVID-19 long hauler with an amniotic fluid-derived extracellular vesicle biologicCase report Published on 2021-08-312022-10-05 Journal: Respiratory Medicine Case Reports [Category] 치료법, [키워드] adverse event amniotic approval biologic Chest COVID-19 COVID-19 symptom demonstrated Extracellular Extracellular vesicles extreme fatigue FDA feasibility fraction Guidance improvement IND Infection Intervention IRB Long COVID Long-hauler Mental oxygen saturation Patient Perinatal physician receiving reported respiratory impairment Safe Shortness of breath shown Symptom Tachycardia therapeutic therapeutic potential therapeutic use Treatment Vesicle X ray [DOI] 10.1016/j.rmcr.2021.101502 [Article Type] Case report
Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospectsReview Published on 2021-08-212022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, [키워드] activities acute respiratory distress acute respiratory syndrome administration Autoimmune benefit cause caused Cell clinical study clinical trial combination therapies coronavirus disease Coronavirus-2 COVID-19 Cytokine storm degenerative Diseases dose Effect exacerbated exaggerated immune response Exosome Exosomes Extracellular Genetic immune response immunomodulation immunomodulatory Inflammatory mesenchymal stem cell Mesenchymal stromal cell Modification morbidity Mortality MSC MSCs novel offer paracrine pathophysiology Population regenerative resulting SARS-CoV-2 supplementary material syndrome the cytokine storm therapeutic potential Therapies therapy Treatment Vesicle virus with COVID-19 [DOI] 10.1186/s13287-021-02542-z PMC 바로가기 [Article Type] Review
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporterArticle Published on 2021-08-202022-10-04 Journal: Nature Communications [Category] 변종, [키워드] bind binding binding pocket binding site Characteristics characterization characterized concentrations cryo-EM Cryoelectron microscopy depressive disorder exhibit Extracellular impede information inhibitor interacting residue Ligand Mental Molecular dynamics simulation molecular interaction molecular pharmacology Mutagenesis nanomolar affinity observé Pharmacodynamics Protein structure predictions resulting reveal selective Serotonin serotonin reuptake inhibitor Structural analysis structural biology target therapeutic Transport Transporters in the nervous system Treatment unique Vilazodone [DOI] 10.1038/s41467-021-25363-3 PMC 바로가기 [Article Type] Article
Integrated single-cell analysis revealed immune dynamics during Ad5-nCoV immunizationArticle Published on 2021-08-102022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] Analysis antibodies approach binding bioinformatics CDR3 Cell cellular immunity clone combating Coronavirus disease 2019 COVID-19 COVID-19 vaccine Critical domain driven by effective Evolution exhibited expressed Extracellular facilitate Health high affinity Humoral immunity identify IFN response immune immune response immunization immunology Infectious disease lineages monoclonal antibody mononuclear cell multicellular Peripheral blood powerful tool Prophylactic Protein public health RNA sequencing Safe SARS-CoV-2 SARS-CoV-2-specific antibodies scRNA-seq sequence single-cell spike tested the vaccine therapeutic trial participant Vaccine Vaccines [DOI] 10.1038/s41421-021-00300-2 PMC 바로가기 [Article Type] Article
NETosis and the Immune System in COVID-19: Mechanisms and Potential TreatmentsPharmacology Published on 2021-08-052022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antiviral chromatin conditions COVID-19 Cytokine storm death Defense element Extracellular extracellular trap Host implicated infections Inflammation initial involved multiorgan failure NETosis NETs neutrophil pathogenesis of COVID-19 pathogenic Potential pro-inflammatory procoagulant promoted Proteins SARS-CoV-2 severe COVID-19 patients severe SARS-CoV-2 System target Therapeutics Treatment [DOI] 10.3389/fphar.2021.708302 PMC 바로가기 [Article Type] Pharmacology
Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patientsNetosis 마커 및 습기의 진화는 중환자가 아픈 Covid-19 환자에서 예후 가치가 있습니다.Article Published on 2021-08-032022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] (cfDNA) Acute inflammation Cell cfDNA Clinical parameters controls coronavirus coronavirus disease coronavirus disease 19 correlated COVID-19 COVID-19 patient COVID-19 patients Critically ill damage DAMP decrease disease severities disease severity Disease-free survival DNA event Evolution Extracellular GAS6 ICU ICU admission immune Infection intensive care intensive care unit lead lowering lowest marker measure molecular pattern molecular patterns Mortality multi-organ dysfunction NETosis neutrophil neutrophil counts Neutrophil elastase Neutrophils Occurrence parameter parameters Patient patient survival plasma Prognostic value Respiratory failure Respiratory tract diseases scoring system Sepsis severe COVID-19 survival the patient tissue damage Ventilator-free days viral infection weakness [DOI] 10.1038/s41598-021-95209-x PMC 바로가기 [Article Type] Article
Dynamics of SARS-CoV-2 Spike Proteins in Cell Entry: Control Elements in the Amino-Terminal Domains세포 진입에서 SARS-CoV-2 스파이크 단백질의 역학: 아미노 말단 도메인의 제어 요소Research Article Published on 2021-08-032022-09-10 Journal: mBio [Category] MERS, SARS, 변종, [키워드] ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive amplify associations binding cell entry change changes in comparison Comparisons complex Control coronavirus coronavirus spike protein coronavirus spike proteins correlated domain driven by Dynamics effective element Extracellular greater inactivation Increased INDEL indels Infection initial membrane fusion murine NTD NTDs Quantitative RBD RBDs Receptor binding receptor-binding domains reduced Region respiratory sarbecovirus SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike Spike protein Spike proteins spikes stability Structure Substitution substitutions susceptible the receptor-binding domain the SARS-CoV-2 Trimers variant Variation variations virus virus entry virus infectivity virus receptors Virus-like particle virus-like particles [DOI] 10.1128/mBio.01590-21 PMC 바로가기 [Article Type] Research Article
The Effects of Aβ 1-42 Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2Article Published on 2021-07-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Aβ ACE2 acute respiratory syndrome Alzheimer’s disease Alzheimer’s disease angiotensin-converting enzyme 2 antibody binding Blood C-terminal clearance coronavirus Course COVID-19 Dementia domain Effect elevated Evidence Extracellular high affinity IL-6 Increasing intravenous mechanism prevented progression receptor reducing residue S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein severe coronavirus disease severity spike the SARS-CoV-2 the spike protein trimer viral entry Viral protein [DOI] 10.3390/ijms22158226 PMC 바로가기 [Article Type] Article