Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissueArticle Published on 2020-08-202022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] ACE2 activated ARDS BMI chronic inflammation clinical observations Control control patient control patients COVID-19 Critical care Critically ill cross cross-sectional Deterioration develop ENhance explain fat increase in Intensive care medicine Leptin Local lung lung tissue mechanical ventilation Microbiology non-infected obese patients pathophysiological produced pulmonary inflammation receptor Research respiratory Respiratory failure Respiratory system risk factor SARS-CoV-2 SARS-CoV-2 infected patient SARS-COV-2 infection serum significantly higher tissue Treatment ventilated patient Virology virus visceral was performed [DOI] 10.1016/j.heliyon.2020.e04696 PMC 바로가기 [Article Type] Article
The impact of obesity on severe disease and mortality in people with SARS‐CoV‐2: A systematic review and meta‐analysisReview Article Published on 2020-08-142022-10-31 Journal: Endocrinology, Diabetes & Metabolism [Category] COVID-19, [키워드] 95% CI 95% CIs 95% confidence interval accompanied Adiposity Admission age Analysis association body mass index CIs Clinical outcome Cochrane Library Cohort COVID‐19 COVID‐19 patient Disseminated intravascular coagulation ectopic eligible excess explained fat functional group heterogeneity increased risk Inflammation Measures Mortality obesity observational study Older Older age outcome Patient prospective cohort study public health messaging raised random effect Result retrospective cohort study risk risk factor SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe disease statistical systematic review Venous Thromboembolism Web of Science [DOI] 10.1002/edm2.176 PMC 바로가기 [Article Type] Review Article
A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly5가지 성분의 영양 보조제 및 가정 기반 저항 운동으로 자유 생활 노인의 제지방 및 근력 향상Article Published on 2020-08-102022-08-13 Journal: Nutrients [Category] 임상, [키워드] age anabolic Analysis body fat casein collagen Combination complement conditions COVID-19 creatine cross-sectional area desensitization double-blind trial Effect effective Efficacy elderly examined exercise fat fatty acids fiber greater grip IMPROVE indicated individual lean mass leg press lower physical activity levels mass men MIS multi-ingredient supplement muscle fiber muscle loss muscle mass old age Older omega-3 Omega-3 fatty acids physical activity levels Placebo placebo-controlled post intervention PROTECT Protein quadricep Randomized randomized clinical trial resistance resistance exercise Safe sarcopenia sarcopenic significantly significantly increased Stand strength sunflower oil therapy Type Vitamin D whey [DOI] 10.3390/nu12082391 PMC 바로가기 [Article Type] Article
Use of chest CT-scan images to differentiate between SARS-CoV-2 infection and fat embolism: A clinical caseEmergency Radiology Published on 2020-07-302022-10-28 Journal: Radiology Case Reports [Category] COVID-19, [키워드] carried chest CT-scan Desaturation differential diagnosis fat fat embolism fatty intensive care Interpretation oxygen pandemic Patient Respiratory failure returned RT-PCR test SARS-CoV-2 SARS-COV-2 infection significantly Symptomatic treatment the SARS-CoV-2 Thoracic CT-scan [DOI] 10.1016/j.radcr.2020.07.071 PMC 바로가기 [Article Type] Emergency Radiology
Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?Observation Published on 2020-07-232022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acid addition Affect Can chronic inflammatory diseases circulation condition contribute contributing to coronavirus disease COVID-19 COVID-19 infection Cytokine storm diabetes Diabetic diet dietary endotoxin Factor fat Gram-negative bacteria Gut gut bacteria high mortality hypertension increase in individual individuals Infection Inflammation Inflammatory response intestinal intestinal permeability intestine Lungs membrane Microbiome microorganism Mortality obese obesity Patient Prevent produced proinflammatory triggered [DOI] 10.1128/mBio.01723-20 PMC 바로가기 [Article Type] Observation
Body Composition Findings by Computed Tomography in SARS-CoV-2 Patients: Increased Risk of Muscle Wasting in ObesityArticle Published on 2020-06-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] applied assist Body body composition caused characteristic complex Complication Computed tomography COVID-19 COVID-19 patient CT scan Diagnostic imaging diagnostics evaluate fat finding frailty greater help high risk Hospitalization ICU increase in Increased increased risk Inflammation lean lean mass liver liver attenuation Long low-grade inflammation Malnutrition management muscle Muscle wasting nutritional status obese obesity paradoxical parameter Pathways Patient profile recognize reduce risk SARS-CoV-2 subjects therapy treat wasting [DOI] 10.3390/ijms21134670 PMC 바로가기 [Article Type] Article
Putative Roles for Peptidylarginine Deiminases in COVID-19Article Published on 2020-06-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] A549 cell lines A549 cells addition alveolar alveolar cell Analysis Anti-viral autoimmune conditions BioProject biopsy bowel cells changes Comorbidities conserved contributing to COVID-19 COVID-19 symptoms disease downregulated elevated enzyme epithelial expression Extracellular extracellular vesicles (EVs) fat Health healthy volunteer highlight Immunity implicated in silico analysis in viral in-host infected cells Infection infections Inflammatory inflammatory pathways isozyme KEGG kidney Kidney injury lung lung epithelial lung tissue mock cells modulation mRNA mRNA level NETosis NHBE organ other tissue PADI1 PADI2 PADI3 PADI4 PADI6 Pathway analysis Patient peptidylarginine deiminases (PADs) phylogenetically Protein protein deimination reduced Regulation response responses reveal role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patients stroke therapeutic target tissue tissue biopsies Transcriptome utilised Variability Variation Vascular Vesicle viral infections [DOI] 10.3390/ijms21134662 PMC 바로가기 [Article Type] Article
COVID-19 suspicion revealed to be fat embolism syndromeCase Report Published on 2020-06-172022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress COVID-19 differential diagnose eliminating fat Fat embolism syndrome Health hidden manuscript Novel coronavirus pandemic Patient responsible SARS-CoV-2 syndrome [DOI] 10.11604/pamj.2020.36.104.23631 PMC 바로가기 [Article Type] Case Report
Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity HabitsReview Published on 2020-05-262022-10-30 Journal: Nutrients [Category] Coronavirus, MERS, SARS, [키워드] activity acute sedentary lifestyle arising cardiovascular disease Chronic diseases condition consequence Consequences COVID-19 COVID-19 pandemic Deleterious detrimental effect diabetes diet dietary intake energy balance Evidence exacerbate Factor fat habit Health help hypertension identify Impact increase increases in Inflammatory cytokines insulin resistance involved mechanism metabolic metabolic consequence metabolic consequences metabolic disorder metabolic syndrome mitigate physical activity Physical inactivity positive positive energy balance potential risk promoted reduce reduced reducing reduction in risk sarcopenia severe COVID-19 severely ill patient step reduction syndrome total body fat turn while with COVID-19 [DOI] 10.3390/nu12061549 PMC 바로가기 [Article Type] Review
TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral TherapyTAILoR(인간 면역결핍 바이러스[HIV]의 TelmisArtan 및 InsuLin 내성): 복합 항레트로바이러스 요법을 받는 HIV 양성 환자의 인슐린 내성 감소를 위한 Telmisartan의 적응형 설계, 용량 범위 IIb상 무작위 시험Articles and Commentaries Published on 2020-05-152022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] adaptive Analysis antiretroviral drugs Antiretroviral therapy Antiretrovirals ARMS cardiovascular disease check clinical Combination conducted Controlled trial demonstrated Efficacy evaluated fat had no HIV HIV infection homeostasis Human Human immunodeficiency virus identify IIb immunodeficiency virus improvement Improvements index individual Infection insulin insulin resistance Insulin sensitivity interim analysis Intervention investigated ISRCTN liver longitudinal longitudinal analysis measure metabolic abnormalities Metabolic abnormality metabolic disease morbidity and mortality multicenter no difference no differences no significant effect once daily Open-label participant Patient phase plasma Primary outcome primary outcome measure Randomized receiving recruited reduce reduction in Registration resistance Result risk secondary outcome measures significant effect Stage stage II telmisartan Trial with HIV [DOI] 10.1093/cid/ciz589 PMC 바로가기 [Article Type] Articles and Commentaries