hACE2 – Page 11 – Communicable Diseases Research

GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy Inhibition

GNS561은자가 포식 억제를 통한 SARS-COV-2에 대한 강력한 항 바이러스 활성을 나타낸다.

Article

Published on 2022-01-122022-09-10
Journal: Viruses [Category] SARS, 치료제,

COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models

SARS-CoV-2 RBD를 암호화하는 전기천공 DNA 백신 후보인 COVID-eVax는 동물 모델에서 보호 반응을 이끌어냅니다.

Article

Published on 2022-01-052022-09-11
Journal: Molecular therapy : the journal of the American So [Category] SARS, 변종, 진단,

[키워드] animal model animal models anti-SARS-CoV-2 Antiviral antiviral immunity approved Brain caused cDNA clinical development COVID-19 COVID-19 pandemic COVID-19 vaccine Critical DNA DNA plasmid DNA vaccine domain effective vaccine Electroporation elicit European expressing ferret ferrets form hACE2 identify immunized K18-hACE2 transgenic mice lung Lungs monomeric Neutralizing antibody response neutralizing antibody responses profile protection protective response Protein Pulmonary function RBD reduced robust Safe SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike secreted Skeletal muscle T cell T cell response the SARS-CoV-2 Trial Vaccine vaccine platform variants of concern Viral Viral antigen viral replication weight loss
[DOI] 10.1016/j.ymthe.2021.09.011 PMC 바로가기 [Article Type] Article

Animal Models of COVID-19: Transgenic Mouse Model

Article

Published on 2022-01-012022-11-15
Journal: Methods in molecular biology (Clifton, N.J.) [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome animal animal model Antiviral Brain C57BL/6 cause caused changes in concern coronavirus coronavirus disease COVID-19 COVID-19 disease cytokeratin 18 promoter death described ELISA enzyme-linked immunosorbent evaluated expressing global public health hACE2 hallmark Histopathology human Angiotensin-converting enzyme IHC immune response immunohistochemistry infected intranasally Infection K18 K18 hACE2 transgenic mice lung Lungs Model morbidity Mortality mouse mouse model nasal nervous system neutralizing monoclonal antibodies pathogenesis of SARS-CoV-2 pathogenicity pathology Prophylactic protocol respiratory tracts responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain spleen Spread survival the cytokine storm therapeutic tissues transgenic transgenic mice Treatment Vaccine viral pathogenesis viral replication virus Wuhan, China
[DOI] 10.1007/978-1-0716-2111-0_16 PMC 바로가기

Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2

SARS-CoV-2에 감염된 K18-hACE2 마우스에 대한 멜라토닌 및 멜라토닌성 약물의 치료 가능성

Article

Published on 2022-01-012022-09-11
Journal: Journal of pineal research [Category] SARS, 변종, 신약개발,

[키워드] administration agomelatine benefit candidate changes in Clinical outcome clinical trials Compound COVID-19 COVID-19 pandemic COVID-19 pathogenesis Cytokines Daily disease dose drug Drug repurposing drug treatment drug treatments drugs effective exacerbated expressing hACE2 human ACE2 receptor humans infected with SARS-CoV-2 Infection Inflammatory cytokine Inflammatory cytokines interferons K18-hACE2 K18-hACE2 mice limit Local lung melatonin mice Occurrence preclinical study Prophylactic ramelteon ramelteon. Safe SARS-CoV-2 SARS-COV-2 infection shown Spread survival susceptible Symptom tested therapeutic therapeutic potential treat treated Treatment type I type I and type III interferons type III Type III interferons vaccination variant
[DOI] 10.1111/jpi.12772 PMC 바로가기 [Article Type] Article

Fruit Bromelain-Derived Peptide Potentially Restrains the Attachment of SARS-CoV-2 Variants to hACE2: A Pharmacoinformatics Approach

Article

Published on 2022-01-012022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection

표면에 ACE2 변이체를 표시하는 조작된 작은 세포외 소포는 SARS-CoV-2 감염으로부터 보호합니다

Article

Published on 2022-01-012022-09-11
Journal: Journal of Extracellular Vesicles [Category] 변종, 비임상,

[키워드] ACE2 ACE2 variant acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral efficacy antiviral therapeutics Beta Beta variant binding interaction breath carriers CD9 Characteristics clinical trial coronavirus COVID-19 D614G variant Delta delta variant displaying dominant effective delivery Efficacy ENhance enzyme Extracellular extracellular vesicle Extracellular vesicles hACE2 host cell host cell surface Infection inhibit Interaction K18-hACE2 mice L452R molecular PROTECT Protein receptor S protein sACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 soluble ACE2 spike the S protein therapeutic efficacy variant variants viral spike wild-type
[DOI] 10.1002/jev2.12179 PMC 바로가기 [Article Type] Article

The Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic Mice

Original Article

Published on 2022-01-012022-10-29
Journal: Journal of Cardiovascular Translational Research [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] ACE2 ACE2 expression acute respiratory syndrome angiotensin converting enzyme 2 antihypertensive drugs AT1 AT1 receptor blocker AT1R ATIR Biomarker blocker cellular entry coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient CRP determine Effect enzyme hACE2 had no Heart injury higher risk hospitalized COVID-19 patient hypertension hypertensive hypertensive COVID-19 patient hypertensive patient IL-1 IL-6 inflammation marker Inpatient kidney outcome Post-infection receptor renin-angiotensin system required SARS-CoV-2 SARS-COV-2 infection serum severity supplementary material transgenic mice treated Treatment
[DOI] 10.1007/s12265-021-10147-3 PMC 바로가기 [Article Type] Original Article

Osteoclast-mediated bone loss observed in a COVID-19 mouse model

COVID-19 마우스 모델에서 관찰된 파골세포 매개 뼈 손실

Article

Published on 2022-01-012022-09-11
Journal: Bone [Category] SARS, 치료기술,

[키워드] added affected aging analyzed animal Asymptomatic body weight bone Bone mass consequence controls cortical cortical bone COVID-19 criteria days post infection death Decline decrease develop eight euthanized examined expressing fraction greater group groups hACE2 Health healthy help human ACE2 human disease human SARS-CoV-2 increase in increases in Infection intranasal K18-ACE2 K18-hACE2 K18-hACE2 transgenic mice knowledge mice moderate moderate disease moderate to severe Musculoskeletal Musculoskeletal health musculoskeletal system no difference no differences non-infected Osteoclasts parameter Patient plaque forming units Post-infection posture receiving reduction in remained resulting risk robust SARS-CoV-2 SARS-COV-2 infection severe disease skeletal staining TRAP treated Viral load viral loads Volume volume fraction were infected while
[DOI] 10.1016/j.bone.2021.116227 PMC 바로가기 [Article Type] Article

Active site-specific quantum tunneling of hACE2 receptor to assess its complexing poses with selective bioactive compounds in co-suppressing SARS-CoV-2 influx and subsequent cardiac injury

Original Article

Published on 2021-12-292022-10-30
Journal: Journal of Advanced Veterinary and Animal Research [Category] COVID-19,

[키워드] active site acute respiratory syndrome Algorithm Analysis apigenin candidate cardiac injury complexes Compound conducted coronavirus defined deviation distribution docking drug drug design exhibited fluctuation forms H-bonds hACE2 hACE2 receptor human Angiotensin-converting enzyme Hydrogen bond hydrophobic interaction Injury Ligand ligands material MDs mechanism metabolism molecular molecular docking Molecular dynamic parameter polar profile profiles programming Protein Quantitative quantum tunneling quercetin receptor Research resulting RMSD RMSF SARS-CoV-2 selected selective Simulation solvent subsequent suggested supramolecular docking target specificity the binding affinity were used
[DOI] 10.5455/javar.2021.h544 PMC 바로가기 [Article Type] Original Article

Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2 -transgenic mice

비활성화된 SARS-CoV-2는 인간 ACE2 형질전환 마우스에서 급성 호흡곤란 증후군을 유발합니다

Article

Published on 2021-12-242022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 Activated neutrophils Activation acute respiratory distress acute respiratory distress syndrome Adaptive immune response alveolar damage animal model animal models ARDS Biological models biosafety biosafety level captures change changes in Characteristics characterized consolidation COVID-19 cytokine Cytokines detrimental develop Dexamethasone Diffuse alveolar damage Disease progression formaldehyde generate hACE2 hemorrhage human ACE2 humans hyaline membrane hyaline membrane formation IL-1β IL-6 induce Infection Infectious diseases infiltration Inflammation Inflammatory inflammatory monocyte Laboratory limit live SARS-CoV-2 lung macrophages mice monocyte-macrophages mouse model necrotic necrotic debris Neutrophils open passive antibody therapy pathologic pathological mechanism progression reported Research researcher respiratory distress Respiratory distress syndrome resulting robust SARS-CoV-2 syndrome T cell T cells the disease Therapeutic strategies therapeutic strategy TNF-α utilization weight loss
[DOI] 10.1038/s41392-021-00851-6 PMC 바로가기 [Article Type] Article