Kinetics of Anti-SARS-CoV-2 Antibody Responses 3 Months Post Complete Vaccination with BNT162b2; A Prospective Study in 283 Health WorkersBNT162b2를 사용한 완전한 백신 접종 후 3개월 후 항-SARS-CoV-2 항체 반응의 동역학; 283명의 의료 종사자를 대상으로 한 전향적 연구Article Published on 2021-07-302022-09-11 Journal: Cells [Category] SARS, 진단, 치료기술, [키워드] age anti-S anti-SARS-CoV-2 anti-SARS-CoV-2 humoral antibodies Antibody Response BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine COVID-19 COVID-19 infection declining decrease dose health worker health workers healthy individuals IgG Immunity in healthy individuals Kinetics median Month NAb NAbs Neutralizing Neutralizing antibodies neutralizing antibody per day Prospective rapid increase RBD IgGs reached response SARS-CoV-2 second vaccination vaccination Vaccine was determined were measured worker [DOI] 10.3390/cells10081942 PMC 바로가기 [Article Type] Article
Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization입원 중 COVID-19 환자에서 변경된 구강 및 장내 미생물 및 SARS-CoV-2 바이러스 부하와의 연관성Article Published on 2021-07-222022-09-12 Journal: NPJ Biofilms and Microbiomes [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] 16S rRNA Alpha alteration Altered association Bacterial baseline Biomarkers calculated clearance clearance of SARS-CoV-2 clinical microbiology collected Community COVID-19 COVID-19 patient COVID-19 patients digestive tract dimension disease elevated examined Fecal sample fecal samples Gut gut microbiota healthy individual healthy individuals Hospitalization identify Immune homeostasis indicated intestinal flora investigated maintenance microbe microbes microbial Microbiome pathophysiology Patient rRNA SARS-COV-2 infection SARS-CoV-2 viral load Sequencing severity Sex susceptibility throat swab Treatment strategies treatment strategy Viral load vital role vital roles [DOI] 10.1038/s41522-021-00232-5 PMC 바로가기 [Article Type] Article
Prolonged Self-Resolving Neutropenia Following Asymptomatic COVID-19 InfectionInternal Medicine Published on 2021-07-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] absolute neutrophil count age ANC approach Asymptomatic COVID-19 asymptomatic patient Bone marrow bone marrow biopsy bone marrow suppression Comorbidity Complication complications of COVID-19 coronavirus disease (COVID-19) COVID-19 diagnostic Evidence febrile illness healthy healthy individuals hematologic increased risk Infection lack leukopenia male malignancy Multiple neutropenia novel coronavirus disease nutritional deficiency physical activity Prolonged reported risk Symptomatic patients Venous Thromboembolism WBC White blood cell [DOI] 10.7759/cureus.16451 PMC 바로가기 [Article Type] Internal Medicine
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort studyArticles Published on 2021-07-172022-10-04 Journal: Lancet (London, England) [Category] Fulltext, SARS, 유전자 메커니즘, [키워드] addition Adult patient age association cardiovascular Care clinical Cohort cohort study Comorbidities Comorbidity complex Complication consequence COVID-19 COVID-19 complication COVID-19 complications COVID-19 illness COVID-19 pandemic defined diagnose discharge disease females finding functional funding hallmark Health health-care health-care system healthy individuals help hospital in-hospital complication in-hospital complications incidence ISARIC liver Logistic regression male management Medical Research Council multicentre neurological Neurological complication Older organ-specific outcome outcomes Patient patients patients with COVID-19 Primary outcome reduced reported respiratory SARS-COV-2 infection self-care survival the patient WHO with COVID-19 [DOI] 10.1016/S0140-6736(21)00799-6 PMC 바로가기 [Article Type] Articles
Development of cavitary lung disease as a long-term complication of coronavirus disease 2019 in a young previously healthy patient: a case reportCase Report Published on 2021-07-132022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, SARS, [키워드] Acute inflammation Case report Cavitary lung lesion Cavity Chest computed tomography chest pain chills clinician Conservative management coronavirus disease COVID-19 development Evidence Fever healthy healthy individuals hospital IMPROVE Infection lung Lung disease male manifestation microorganisms Necrosis pleuritic pulmonary disease recognize reported SARS-CoV-2 Shortness of breath surgical surgical pathology therapy tissue variety while [DOI] 10.1186/s13256-021-02961-9 PMC 바로가기 [Article Type] Case Report
Serologic Status and Toxic Effects of the SARS-CoV-2 BNT162b2 Vaccine in Patients Undergoing Treatment for CancerResearch Published on 2021-07-082022-10-30 Journal: JAMA Oncology [Category] COVID-19, [키워드] 95% CI Administered administration adverse effect adverse event Adverse reaction age antibody production anticancer appear blood cell counts BNT162b2 BNT162b2 vaccine Campus Cancer Chemotherapy Cohort cohort study collected conducted Control controls COVID-19 case COVID-19 infection determine division Effect Efficacy Efficacy and safety electronic medical record enrolled evaluate evaluated exposure finding first dose Future Health care worker healthy healthy individuals high-risk population IgG Importance incidence initiated leukopenia liver enzyme measure men objective occur occurred Odds ratio of BNT162b2 participant Patient patients Patients with cancer Phase 3 Point populations rate ratio reached real-world data receiving reduced Regulatory Relevance reported Result Safe SARS-CoV-2 BNT162b2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose Seroconversion serologic seronegative patients Seronegativity seropositive serum serum sample setting Sociodemographic characteristics status Testing the healthy the patient the SARS-CoV-2 the vaccine therapy toxic Treatment Trial trials vaccination Vaccine vaccine dose was used [DOI] 10.1001/jamaoncol.2021.2675 PMC 바로가기 [Article Type] Research
Detection of pre-existing SARS-CoV-2-reactive T cells in unexposed renal transplant patients노출되지 않은 신장 이식 환자에서 기존 SARS-CoV-2 반응성 T 세포 검출Original Article Published on 2021-07-062022-09-10 Journal: Journal of Nephrology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antigen-spcific T cells Antiviral Blood donors CD4 CD8 Cohort collected competent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines demonstrated detectable detection expression pattern flow cytometry Frequency healthy healthy blood donors healthy individuals immune Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppression magnitude majority Neutralization assay not differ nucleocapsid pandemic Patient patients positive controls pre-existing immunity pro-inflammatory cytokine pro-inflammatory cytokines produced Protective reactive reactivity recent renal Renal transplantation required respiratory Result SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 protein severe acute respiratory syndrome Coronavirus supplementary material T cell T cells Th1 cytokine the SARS-CoV-2 were used [DOI] 10.1007/s40620-021-01092-0 PMC 바로가기 [Article Type] Original Article
Preexisting vs. de novo antibodies against SARS-CoV-2 in individuals without or with virus infection: impact on antibody therapy, vaccine research and serological testingCommentary Published on 2021-07-012022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] antibody complicate cross-reactive antibodies de novo Epidemiology exhibited healthy individuals identify immune response Inclusion individual limitations Neutralizing activity nucleocapsid protein observation overcome pandemic positive potential limitation progressed PROTECT RBD receiving recent reported Research RT-PCR SARS-CoV-2 SARS-COV-2 infection sera serological test Serological testing Spike protein tested therapy Topic Treatment Vaccine virus while [DOI] 10.1186/s41231-021-00093-2 PMC 바로가기 [Article Type] Commentary
Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors나노플라즈몬 바이오센서를 활용한 SARS-CoV-2 감염의 RNA/스파이크 단백질/IgG/IgM 바이오마커의 다중 및 고처리량 무표지 검출Article Published on 2021-06-292022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody applied approach Biomarker biosensor calculated caused Characteristics clinician coronavirus COVID-19 COVID-19 outbreak COVID-19 pandemic detect detection diagnostic diagnostic test diagnostic tests diagnostics disease effective Genes healthy individual healthy individuals IgG and IgM IgM antibodies Infection limit of detection Mann-Whitney nonparametric MOST multiplex Negative predictive value nonparametric test P -value Patient plasma sample plasma samples platform Positive predictive value positive rate Predictive value Prevalence progression proof proof of concept provide receiving respiratory responses SARS-CoV-2 screening test sensitivity severe acute respiratory syndrome Coronavirus severity specificity Spike protein Stage subunits Treatment true negative true positive rate unmet need Viral viral nucleic acid virus [DOI] 10.1021/acs.analchem.0c05300 PMC 바로가기 [Article Type] Article
Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseasesArticle Published on 2021-06-212022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] activity Acute myocardial infarction Analysis analyzed AUC Biomarker Biomarkers Cancer candidate Candidates clinically defined diagnostic Diagnostic markers disease Diseases expressed Gout healthy individuals Hepatic encephalopathy highest human disease human diseases investigated Ischemia lactate dehydrogenase LDH living cells Lung fibrosis MOST Patient prognostic Protein sensitivity serum significantly significantly increased specificity the healthy the median Treatment [DOI] 10.1038/s41598-021-92430-6 PMC 바로가기 [Article Type] Article