Spread of Mink SARS-CoV-2 Variants in Humans: A Model of Sarbecovirus Interspecies EvolutionMicrobiology Published on 2021-09-202022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3D structure ACE2 Antibody neutralization circulation consequence COVID-19 COVID-19 vaccines Denmark enzyme epitope Evolution exhibited Human human ACE2 humans immune response linear mink mink coronavirus Model monoclonal antibody Mutation neutralization Neutralizing antibodies NRP-1 predicted Prevalence sarbecovirus SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 vaccines SARS-CoV-2 variant Spread susceptibility target unlikely Vaccine variant variant viruses [DOI] 10.3389/fmicb.2021.675528 PMC 바로가기 [Article Type] Microbiology
A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels항 바이러스 스크리닝 및 모니터링 환자 중화 항체 수준에 대한 생물 발광 및 균질 한 SARS-COV-2 스파이크 RBD 및 HACE2 상호 작용 분석Article Published on 2021-09-162022-09-01 Journal: Scientific Reports [Category] SARS, 변종, 신약개발, 진단, 치료기술, 치료제, [키워드] ACE2 ACE2 binding Anti-RBD antibodies antibody Antiviral apparent affinity binding affinity Biological techniques bioluminescent Brazil can be used changes in Clinical research COVID-19 demonstrated doses Drug discovery E484K E484K mutation epitope escaped hACE2 homogeneous human ACE2 Immunity immunoassay immunology Infectious diseases inhibitor Interaction methodology miniprotein N501Y mutation NAb NAbs Nanoluc luciferase Neutralizing activity Neutralizing antibodies neutralizing antibody Patient persistence populations positive sample RBD RBD mutation RBD mutations Region Research SARS-CoV-2 SARS-CoV-2 Spike RBD secondary antibodies secondary antibody sera soluble ACE2 spike symptom onset tested the binding affinity USA utility vaccinated individual vaccinated individuals [DOI] 10.1038/s41598-021-97330-3 PMC 바로가기 [Article Type] Article
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy생쥐에서 SARS-CoV-2 감염의 실시간 영상은 중화 항체가 최적의 효능을 위해 Fc 기능을 필요로 함을 보여줍니다Article Published on 2021-09-142022-09-11 Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] addition Administered antibody applied bioluminescence imaging BLI Brain convalescent COVID-19 death Effect effective Efficacy Fab Fc effector functions Fc function function hACE2 highlight human ACE2 human ACE2 transgenic mice immune protection immunopathology in vivo indicated Infection Inflammatory response Inflammatory responses Interaction intranasally K18-hACE2 mice limit lung Lungs mechanism mice MONITOR Monocytes NAb NAbs nanoluciferase nasal Nasal cavity natural killer natural killer cell Natural killer cells neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutrophils organ Pathogenesis prevented Prophylaxis required resolved reveal SARS-CoV-2 SARS-COV-2 infection subject systemically therapy transgenic treating COVID-19 Treatment virus spread [DOI] 10.1016/j.immuni.2021.08.015 PMC 바로가기 [Article Type] Article
Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2Research Article Published on 2021-09-082022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 glycoprotein ACE2 receptor ACE2-spike binding addition antiviral therapy approach binding biological activities Cell cell entry receptor cell membrane coronavirus Critical demonstrated disrupt Endoplasmic reticulum enzyme examined expression function glycosylation hACE2 Human human ACE2 illness implicated Infection Interaction Mutagenesis N-glycan N-glycosylation N-linked glycan not affected offer property Protein Pseudotyped viruses receptor recruitment reduced reducing required role S proteins SARS Coronavirus SARS-CoV SARS-CoV S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 S protein subsequent Support surface susceptibility syncytium formation transmembrane glycoprotein Treatment type I understanding viral entry viral spike virus entry [DOI] 10.1128/Spectrum.01199-21 PMC 바로가기 [Article Type] Research Article
Multiorgan tropism of SARS-CoV-2 lineage B.1.1.7Short Communication Published on 2021-09-062022-10-29 Journal: International Journal of Legal Medicine [Category] COVID-19, SARS, [키워드] Analysis Autopsy B.1.1.7 Brain Cohort death detection facilitate First wave highlighting human ACE2 increased mortality initial kidney Lineage B.1.1.7 liver lung morbidity and mortality multiple organs Nasopharyngeal swab normalized obligatory organ Organ tropism pandemic Respiratory system respiratory tract RT-qPCR SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 lineage SARS-CoV-2 variant the SARS-CoV-2 tissue tissue analysis Transmission tropism of SARS-CoV-2 variants of concern Viral load [DOI] 10.1007/s00414-021-02691-z PMC 바로가기 [Article Type] Short Communication
Identification of potential plant bioactive as SARS-CoV-2 Spike protein and human ACE2 fusion inhibitorsSARS-CoV-2 스파이크 단백질 및 인간 ACE2 융합 억제제로서 잠재적인 식물 생리활성 확인Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료제, [키워드] acceptance ACE2 Analysis approach binding Cell Dicaffeoylquinic acid docking Ensemble clustering host cells human ACE2 identification in-silico In-vitro indicated Infection inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 inhibitory Interaction involved MD simulations MM-PBSA molecular molecular docking molecular dynamics plant Protein protein-ligand interaction protein-ligand interactions Receptor binding domain residue S-RBD S-RBD. SARS-CoV-2 spike Spike receptor binding domain surface protein target cell target cells Therapeutics viral entry virus [DOI] 10.1016/j.compbiomed.2021.104631 PMC 바로가기 [Article Type] Article
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker강력하고 광범위한 코로나바이러스 차단제로서의 ACE2 표적 단클론항체Article Published on 2021-08-252022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단, 치료제, [키워드] ACE2 affecting Alanine angiotensin B.1.1.7 B.1.351 B.1.617.1 binding blocked CDR3 clinical development coronavirus Coronaviruses COVID-19 cryo cryo-EM D614G domain Drug development entry receptor epitope Evolution HCoV HCoV-NL63 heavy chain human ACE2 human Angiotensin-converting enzyme in vitro Infection Infectious diseases live SARS-CoV-2 management mice monoclonal antibody multiple coronaviruses mutant non-human primate non-human primates P.1 physiological activities physiological activity Prophylactic provided residue SARS-CoV SARS-CoV-2 SARS-COV-2 infection Toxicity variant virus [DOI] 10.1038/s41392-021-00740-y PMC 바로가기 [Article Type] Article
A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptationSpike 유전자의 선택적 스윕은 SARS-CoV-2 인간 적응을 주도했습니다Article Published on 2021-08-192022-09-11 Journal: Cell [Category] Coronavirus, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive assays bat bats binding cellular receptor contributed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G D614G mutation domain emergence Evolution Genome glycosylation greater hACE2 higher affinity hosts human ACE2 human lung cell human lung cells human SARS-CoV-2 human-to-human transmission molecular molecular virology mutant Mutation Non-synonymous pandemic pangolins Positive selection predicted RBD related virus Replication reservoir SARS-CoV-2 selective selective sweep sequence severe acute respiratory syndrome Coronavirus Spike protein spillover sustained the Spike the spike protein Transmission variant viral adaptation wild-type [DOI] 10.1016/j.cell.2021.07.007 PMC 바로가기 [Article Type] Article
Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular ReceptorArticle Published on 2021-08-182022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 ACE2 protein ACE2 sequence acute respiratory syndrome amino acid residue Betacoronavirus binding Binding interface cellular receptor complexes COVID-19 Dissection evidenced experimental structure Host host cells Human human ACE2 implication in silico analysis Interaction Invasion K417 molecular interaction Mutagenesis N-terminal new coronavirus SARS-CoV-2 outbreak outcome R426 RBD Receptor-binding domain (RBD) reported residue SARS-CoV-1 SARS-CoV-2 Spread Support viral spike-protein [DOI] 10.3390/biomedicines9081038 PMC 바로가기 [Article Type] Article
Molecular Dynamics Studies on the Structural Characteristics for the Stability Prediction of SARS-CoV-2SARS-CoV-2의 안정성 예측을 위한 구조적 특성에 관한 분자 역학 연구Review Published on 2021-08-132022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, [키워드] 3D structure ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis bind binding free energy binding free energy calculation conformational coronavirus COVID-19 pandemic D614G domain Dynamics fluctuation form forms free energy global pandemic human ACE2 human cell human cells Interaction investigated involved Korean L455F MD simulation mutant mutants patients performed prediction prevalent Protein RBD RBD region released respiratory Respiratory system S2 domain SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein stability the RBD variant wild type [DOI] 10.3390/ijms22168714 PMC 바로가기 [Article Type] Review