Therapy with lopinavir/ritonavir and hydroxychloroquine is associated with acute kidney injury in COVID-19 patients로피나비르/리토나비르 및 하이드록시클로로퀸을 사용한 치료는 COVID-19 환자의 급성 신장 손상과 관련이 있습니다Research Article Published on 2021-05-112022-09-10 Journal: PLoS ONE [Category] SARS, 치료제, [키워드] Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect AKI Analysis analyzed Antiviral agents both groups Care control group controls coronavirus coronavirus disease correlation COVID-19 COVID-19 patient COVID-19 patients creatinine CYP3A4 cytochrome P450 enzyme Germany Hospitalized Hydroxychloroquine ICU ICU patient ICU Patients in both group in vitro activity incidence increase in independent risk factor Interaction Kidney function Kidney injury linear linear correlation Lopinavir Lopinavir/ritonavir mechanism Mortality National Early Warning Score NEWS non-ICU non-ICU patients P450 Patient patients R 2 receiving respiratory Result Ritonavir SARS-CoV-2 score serum creatinine severe acute respiratory syndrome Coronavirus severely ill COVID-19 patients severity severity of illness Standard therapy therapy treated Treatment treatment of COVID-19 university university hospital was performed with COVID-19 [DOI] 10.1371/journal.pone.0249760 PMC 바로가기 [Article Type] Research Article
Suggestions for global coagulation assays for the assessment of COVID-19 associated hypercoagulabilityCOVID-19 관련 과응고성 평가를 위한 글로벌 응고 분석에 대한 제안Article Published on 2021-05-012022-09-11 Journal: Thrombosis research [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted Alter Analysis Anticoagulant change Clotting time coagulant Coagulation Coagulopathy condition conditions coronavirus COVID-19 decrease Diagnosis diagnostic dose effective Effectiveness ellagic acid expected fibrinogen Fibrinogen levels fibrinolytic Final Follow-up healthy volunteers heparin heparins HPPH hypercoagulability ICU Patients Infection influence influences inhibitory effect LMWH material normalized outcome parameters pathophysiological mechanism patients phenotype plasma Population Prognosis prothrombotic protocol quantification reagent risk ROTEM SARS-CoV2 sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suggestion thrombin Thrombin generation thrombosis tissue Tissue Factor triggered Variability variants was performed was used [DOI] 10.1016/j.thromres.2021.02.026 PMC 바로가기 [Article Type] Article
Increased Serum Levels of Soluble TNF-α Receptor Is Associated With ICU Mortality in COVID-19 Patients가용성 TNF-α 수용체의 증가된 혈청 수준은 COVID-19 환자의 ICU 사망률과 관련이 있습니다Immunology Published on 2021-04-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Admission age ARDS Biomarker cause Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease cytokine Cytokine storm death determinant determinants disease disease severity ELISA ESR Future greater healthy control healthy subjects ICU ICU patient ICU Patients Increased intensive care intensive care unit Iran laboratory-confirmed Laboratory-confirmed COVID-19 Level Mild Mortality non-ICU non-ICU patient non-ICU patients objective Older outcome Patient positively correlated receptor recruited respiratory respiratory distress Respiratory distress syndrome Result SARS-CoV-2 serum Serum level serum levels severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients severe disease significantly higher soluble TNF-α subject syndrome Tehran the healthy TNF-α TNF-α Ventilation [DOI] 10.3389/fimmu.2021.592727 PMC 바로가기 [Article Type] Immunology
Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort studyCOVID-19 유무에 관계없이 ICU 환자의 숙주 내피, 상피 및 염증 반응의 비교: 전향적 관찰 코호트 연구Observational Study Published on 2021-04-192022-09-11 Journal: Critical Care [Category] MERS, 바이오마커, 임상, [키워드] Acute kidney injury acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amyloid A angiopoietin biological pathway Biomarker Blood both groups cause cell injury characteristic collected Concentration coronavirus COVID-19 Critical Critical illness Critically ill demographics diagnose diagnoses end products endothelial Endothelial dysfunction enrolled epithelial epithelial cell evaluate followed by groups Host host response ICU admission ICU patient ICU Patients in both group in-hospital mortality Inflammation Inflammatory biomarker Inflammatory response interleukin interleukin 6 Invasive mechanical ventilation involved marker Mortality Necrosis Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients not different Pathways Patient plasma biomarker Pneumonia positive proportion prospective observational cohort Protein receptor respiratory respiratory distress Respiratory distress syndrome Respiratory failure Result resulting SAA SARS-CoV-2 SARS-COV-2 infection Sepsis serum amyloid severe acute respiratory syndrome Coronavirus severe COVID-19 significantly higher significantly lower sTNFR study enrollment supplementary material syndrome target targets Therapeutics Tumor tumor necrosis tumor necrosis factor Viral viral infection while [DOI] 10.1186/s13054-021-03547-z PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Renal Impairment in Critical Care: An Observational Study of 42 Cases (Kidney COVID)Article Published on 2021-04-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Acute kidney injury acute respiratory syndrome adjusted AKI Analysis Blood C-reactive protein category characterized Chronic kidney disease clearance Comorbidity conducted coronavirus COVID Critical CRP determine Diagnostic Criteria discharge Evolution French glomerular hemodynamic hospital discharge Hospitalization ICU ICU admission ICU Patients impairment increased mortality Infection Injury intensive care unit intrinsic intrinsic renal injury kidney logistic regression model Mechanical Mortality Occurrence Patient patients PEEP performed Pneumonia positive Positive end-expiratory pressure predictor Probability procalcitonin profile Proteinuria renal renal function renal impairment risk factor SARS-CoV-2 SARS-COV-2 infection tested Treatment university hospital Ventilation Weighting [DOI] 10.3390/jcm10081571 PMC 바로가기 [Article Type] Article
Clinical features and predictors of severity in COVID-19 patients with critical illness in SingaporeArticle Published on 2021-04-052022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] 95% CI Admission APACHE II score ARDS C-reactive protein case sery characteristic clinical clinical feature collected COVID-19 patient Critical described Dyspnea elevated feature FiO2 groups ICU Patients independent predictor intubation IQR Laboratory lactate dehydrogenase management mechanical ventilation Mortality MOST multivariable logistic regression neutrophil count Older PaO2/FiO2 ratio Patient Positive end-expiratory pressure predictor Prospective Study reported required Respiratory distress syndrome respiratory rate severity significantly Singapore Ventilation ventilatory viral infection [DOI] 10.1038/s41598-021-81377-3 PMC 바로가기 [Article Type] Article
Inspiratory muscle training for recovered COVID-19 patients after weaning from mechanical ventilation: A pilot control clinical studyArticle Published on 2021-04-022022-10-05 Journal: Medicine [Category] SARS, 임상, [키워드] 6-MWT age Analysis change clinical study control group COVID-19 COVID-19 patient DSI Dyspnea Effect Efficacy enrolled evaluated expiratory forced vital capacity functional functions ICU ICU Patients IMPROVE inspiratory muscle intensive care interaction effect Intervention knowledge management protocol mechanical ventilation men Patient Quality of life recovered COVID-19 patient recruited severity Significant Volume were assessed women [DOI] 10.1097/MD.0000000000025339 PMC 바로가기 [Article Type] Article
Severe acute kidney injury in critically ill COVID-19 patientsObservational Study Published on 2021-04-012022-10-05 Journal: Journal of Nephrology [Category] SARS, 임상, [키워드] Acute kidney injury Admission AKI assessment Barcelona Characteristics correlation COVID-19 COVID-19 patient Critically ill Diagnosis Factor failure high mortality Hospital stay ICU ICU Patients independent predictor inflammation marker intensive care kidney Kidney injury liver median moderate-severe Mortality outcome Patient patients Prevalence progression Prospective reduced renal replacement therapy replacement required RRT SOFA Spain study period the patient therapy use of corticosteroid [DOI] 10.1007/s40620-020-00918-7 PMC 바로가기 [Article Type] Observational Study
Improving racial disparities in unmet palliative care needs among intensive care unit family members with a needs-targeted app intervention: The ICUconnect randomized clinical trialRandomized Controlled Trial Published on 2021-04-012022-10-05 Journal: Contemporary clinical trials [Category] SARS, 임상, [키워드] Anxiety Arm assist baseline black Black patient Care clinical impact clinical trial clinician concerning Concordance conducted COVID-19 pandemic Critical illness determine EHR Electronic health record Electronic health record (EHR) systems enrolled Health healthcare Hierarchical ICU ICU Patients ICUs Improving include intensive care intensive care units interaction term Intervention intervention effect Linear model manuscript Mobile Mobile App outcome palliative Palliative care parallel group participant physician Post-traumatic stress disorder Primary outcome Psychological distress Racial Racial health disparities Randomized randomized clinical trial Randomized clinical trial (RCT). RCT receive reduce reducing remained resource secondary symptoms of depression their family members treat Two-arm usual care white [DOI] 10.1016/j.cct.2021.106319 PMC 바로가기 [Article Type] Randomized Controlled Trial
Administration of high titer convalescent anti-SARS-CoV-2 plasma: From donor selection to monitoring recipient outcomes고역가 회복기 anti-SARS-CoV-2 혈장 투여: 기증자 선정부터 수혜자 결과 모니터링까지Article Published on 2021-04-012022-09-12 Journal: Human immunology [Category] MERS, SARS, 진단, [키워드] access Administered adverse event anti-SARS-CoV-2 antibody Brooklyn center conducted convalescent convalescent plasma Convalescent plasma donation and treatment COVID-19 domain Donor eligible ELISA Extended hospitalized COVID-19 patients ICU ICU Patients IgG titer IgM and IgG Lateral lateral flow Lateral flow antibody assay less Mayo Clinic Mortality MOST New York outcome pandemic Patient plasma positive Potential Program RBD receive SARS-CoV-2 screened selected severely ill patients tested the RBD the SARS-CoV-2 therapy Treatment Treatment protocol university volunteers [DOI] 10.1016/j.humimm.2021.02.007 PMC 바로가기 [Article Type] Article