IL-2 – Page 11 – Communicable Diseases Research

The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study

Articles

Published on 2021-07-082022-10-29
Journal: The Lancet Rheumatology [Category] COVID-19,

Elevation of Serum Cytokine Profiles and Liver Metabolomic Normalization in Early Convalescence of COVID-19 Patients

Medicine

Published on 2021-07-072022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] addition alanine aminotransferase amino acid metabolism association B-cell change clinical manifestation convalescence convalescent phase Coronavirus disease 2019 correlations COVID-19 COVID-19 patient cytokine cytokine profile Cytokines decrease demonstrated discharged patient elevated Elevation functions global public health hospital discharge IFN-γ IL-10 IL-2 IL-4 IL-6 immune implication Injury interferon-γ lipid metabolism liver Liver function Liver injury liver repair metabolomic metabolomic analysis metabolomics normalization performed physiological effect profile profiles Retrospective study returned SARS-CoV-2 serum cytokine significantly supported T-cell Treatment tumor necrosis factor-α UPLC/Q-TOF-MS viral replication
[DOI] 10.3389/fmed.2021.626633 PMC 바로가기 [Article Type] Medicine

Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning

기계 학습을 사용하여 디코딩된 COVID-19 심각도 및 만성의 면역 기반 예측

Immunology

Published on 2021-06-282022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

[키워드] activated T cells Activation activities analyzed approach B-cell bioinformatics CCL3 CCL4 CCR5 CD14+ CD16+ CD4 CD8 characterized chemokines Classifier continuum COVID COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient cytokine Cytokines dataset defined disease dysregulated effective effector T cell elevated excessive inflammation expressing generate GM-CSF healthy control healthy controls identify IFN-γ IL-10 IL-2 IL-4 IL-6 IL-8 immune response implicated individual individuals induce investigated Ligand machine learning Model mononuclear cell PASC Patient PBMCs Peripheral blood plasma positive predict prediction pro-inflammatory random recruitment second significantly significantly lower subset Symptoms T cell activation T-cell T-regulatory cell treatment strategy VEGF virus while
[DOI] 10.3389/fimmu.2021.700782 PMC 바로가기 [Article Type] Immunology

Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infection

SARS-CoV-2 감염 연구를 위한 최고의 항원 및 최고의 면역 바이오마커를 식별하기 위한 탐색적 분석

Research

Published on 2021-06-262022-09-10
Journal: Journal of Translational Medicine [Category] MERS, SARS, 바이오마커, 치료기술,

[키워드] acute COVID-19 Analysis Antibody Response Antigen approach AUC best Biomarker Biomarkers Clinical characteristics cohorts COVID-19 demonstrated described develop diagnostics discriminant analysis Disease progression Eotaxin evaluate evaluated Factor FGF foundation G-CSF GM-CSF HCV help highest identify IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-17A IL-1ra IL-1β IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 immune immune factors immune response Immunity immunogenic immunogenicity induce Infectious disease IP-10 knowledge MCP-1 membrane MIP-1α MIP-1β not affect nucleoprotein ORF3a partial least square Patient PDGF peptide peptide pool peptides RANTES recent recovered patients Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV2 SARS-CoV2 infection serological spike Spike-based vaccine spike-protein T-cell T-cell Response TNF-α Treatment strategies Tuberculosis Vaccine vaccine candidates vaccine trial VEGF Viral Viral antigen virus Whole-blood
[DOI] 10.1186/s12967-021-02938-8 PMC 바로가기 [Article Type] Research

The Role of Th17 Response in COVID-19

Review

Published on 2021-06-192022-10-31
Journal: Cells [Category] COVID-19, MERS, SARS,

[키워드] activating acute infectious disease cascade caused colony stimulating factor coronavirus 2 counterproductive Course COVID-19 COVID-19 pneumonia cytokine Cytokines Defense droplet Evidence G-CSF granulocyte hospitalised IL-10 IL-17 IL-2 IL-6 IL-7 IL-8 ill patient immune response immune system Increasing Infection inhibiting interleukin MCP-1 monocyte Necrosis occur pathogenesis of COVID-19 Protein respiratory Respiratory system response role SARS-CoV-2 SARS-COV-2 infection target Th1 Th17 Th17 cell Th17 pathway Th17 response Th2 responses the SARS-CoV-2 virus therapeutic intervention TNF Treg cells viral infection with COVID-19
[DOI] 10.3390/cells10061550 PMC 바로가기 [Article Type] Review

COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality

Immunology

Published on 2021-06-182022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory distress adaptive adipocyte adipose antigen-presenting cells Autoimmune disorders characteristic circulating contribute Coordinate Coronavirus infection COVID-19 COVID-19 patient cytokine cytokine secretion death Diseases dysregulation Fat mass function high mortality rate IL-2 IL-6 immune response Immunity Impact increase in Inflammation inflammatory condition Inflammatory cytokine Inflammatory responses Leptin long-lasting mechanism Monocytes Mortality obesity outcome pandemic progresses Patient patients with obesity plasma pleiotropic Pneumonia pro-inflammatory cytokine proliferation proportion response resulting risk factor SARS-COV-2 infection secretion severity susceptibility syndrome T helper cells Th1 the disease These cells tissue TNF-α
[DOI] 10.3389/fimmu.2021.649359 PMC 바로가기 [Article Type] Immunology

Coordinate Induction of Humoral and Spike Specific T-Cell Response in a Cohort of Italian Health Care Workers Receiving BNT162b2 mRNA Vaccine

Brief Report

Published on 2021-06-162022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] age anti-RBD Assessing BNT162b2 mRNA BNT162b2 mRNA vaccine cell-mediated immune cell-mediated immune response cell-mediated response Cohort Coordinate coordinate immunity correlated Effective vaccines effort elicit evaluated HCW HCWs Health care worker health care workers Hospitalization humoral IFN-γ IL-2 immune induction Italian moderate mRNA vaccine Neutralizing Neutralizing antibodies parameter peptide peptides persistence produced protocol public health measure reduce response SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV2 serological response Specific spike spike-specific T cell T cell Th1 cytokine the vaccine TNF-α to define vaccination Vaccination strategy Vaccine was performed Whole blood whole blood T cell assay worker
[DOI] 10.3390/microorganisms9061315 PMC 바로가기 [Article Type] Brief Report

Viral loads, lymphocyte subsets and cytokines in asymptomatic, mildly and critical symptomatic patients with SARS-CoV-2 infection: a retrospective study

SARS-COV-2 감염을 앓고있는 무증상, 경미하고 중요한 증상 환자의 바이러스 부하, 림프구 서브 세트 및 사이토 카인 : 후 향적 연구

Comparative Study

Published on 2021-06-122022-09-01
Journal: Virology Journal [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age ANOVA Asymptomatic asymptomatic individual Asymptomatic individuals asymptomatic patient asymptomatic patients attack B cell B cells biological microscope Cell Chi-square Concentration coronavirus coronavirus disease coronavirus disease-2019 correlated COVID-19 Critical Critical case cytokine Cytokines diabetes Diabetes Mellitus disease enrolled Fisher Fisher's exact test flow cytometer Flow cytometric analysis group hospital Hospitalization IFN-α IFN-γ IL-10 IL-2 IL-5 IL-6 IL-8 IL10 IL2 IL4 IL5 IL6 IL8 infected individuals interleukin laboratory characteristics lymphocyte Lymphocyte subset Lymphocytes lymphopenia marker Microscope Mild Mild symptom mild symptoms NK cell NK cells No statistical differences occurred Patient patients patients with COVID-19 Plasma cytokine Pneumonia positively correlated respiratory Respiratory system Result Retrospective study RT-PCR SARS-CoV-2 SARS-COV-2 infection SCS severe acute respiratory syndrome Coronavirus severity of COVID-19 significant difference source of infection sputum statistical difference statistical differences subject subset symptomatic patient Symptomatic patients T cells T lymphocytes throat-swab TNF-α underlying disease underlying diseases variance Viral Viral load viral loads was used with COVID-19
[DOI] 10.1186/s12985-021-01597-x PMC 바로가기 [Article Type] Comparative Study

Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19

Covid-19에 대한 Nigella sativa와 Thymoquinone의 가능한 치료 효과

Review

Published on 2021-06-102022-08-31
Journal: Pharmaceutical Biology [Category] SARS, 치료제,

[키워드] animal Anti-inflammatory Antiviral antiviral effects cause Clinical studies clinical study clinical trial clinical trials Context COVID-19 database Effect Effects Efficacy flowering plant Google Scholar IFN-γ IgG1 IgG2a IL-12 IL-2 IL-4 IL-6 immunomodulation immunomodulatory effect immunomodulatory effects immunomodulatory properties immunomodulatory property infected patient infected patients ISI literature review mediators medicinal plant molecular docking Nigella Sativa Novel coronavirus objective Preliminary data pro-inflammatory mediator pro-inflammatory mediators Pulmonary function test randomize reduced respiratory respiratory disorders Respiratory system Result searched Serum level serum levels Severe infection suggested therapeutic effect thymoquinone Treatment Web of Science with COVID-19
[DOI] 10.1080/13880209.2021.1931353 PMC 바로가기 [Article Type] Review

Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates

2개의 새로운 아데노바이러스 매개된 COVID-19 백신 후보로 생쥐와 붉은털 원숭이의 프라임 부스트 백신 접종

Research Article

Published on 2021-06-012022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술,

[키워드] Adenovirus animals anti-RBD anti-S binding antibody candidate CD4 cells changes COVID-19 vaccine COVID-19 vaccines detectable dose-dependent manner elicit evaluated FIVE followed by full-length human adenovirus 49 vector IFN-γ IL-2 immune response immune responses Immunity immunization immunogenicity macaque macaques mice mice and non-human primates nCoV pathologic peptide peptides preparation prime-boost regimen prime-boost vaccination priming pseudovirus neutralizing antibody response rhesus macaque rhesus macaques SARS-CoV-2 spike protein simian adenovirus 23 vector Specific Spike protein T cell T-cell Response the vaccine trials vaccination Vaccine
[DOI] 10.1080/22221751.2021.1931466 PMC 바로가기 [Article Type] Research Article