Impaired
[용어속성] Term
Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol
Letter
[키워드] 1:1
24 hour
Administered
airway
allocation concealment
Alpha
ambient
analysed
aneurysms
Anticoagulant treatment
anticoagulation
antiplatelet
Arm
arterial
assigned
Atrial fibrillation
bleeding
bleeding event
block size
Blood
BMI
Body
Breastfeeding
breath
calculated
Cancer
clinical
clinically
Coagulopathy
Concomitant
conjunctival
Continuous
contributed
Control
control group
Controlled trial
corpus
COVID-19
COVID19
criteria
Critical
D-dimer
D-dimer level
Day
death
defined
detect
diagnostic
discharged
disease severity
dissemination
dosage
dose
effective
Efficacy and safety
element
enoxaparin
Epistaxis
EudraCT
event
events
expected
fibrinogen level
gingival bleeding
group
Haemoglobin
haemoptysis
health-care
hematemesis
hematoma
hemodynamic
heparin
High dose
high risk
history
hospital discharge
Hospital stay
hospitalized patient
hypersensitivity
Hypothesis
IL-6
Impaired
impairing
improvement
IMV
In-hospital
indication
initiated
Inpatient
INR
internal
Intervention
intervention group
Intra-articular
intramuscular
invasive
Invasive mechanical ventilation
involved
Italian
Italy
laboratory parameter
LMWH
low dose
low-molecular weight heparin
macroscopic
Major
major bleeding
management
Mechanical
mechanical ventilation
medical intervention
Medicine
Modena
NIV
Non-invasive
number
objective
occur
Occurrence
open label
ophthalmic
oral anticoagulant
outcome
oxygen
paO2/fiO2
parallel group
participant
pathology
Patient
performed
Pharyngeal swab
plasma
Platelet
Pneumonia
positive
pregnancy test
Presence
pressure
Primary outcome
prophylactic dose
prosthetic
protocol
random
randomisation
randomised
randomised controlled
randomised controlled trial
randomization
Rate
receiving
recorded
recruited
Rectal Bleeding
reduce
reduction in
Registered
renal function
reported
required
respiratory
risk
risk of death
Sample size
SARS-CoV-2
secondary
secure
Severe COVID-19 pneumonia
severe disease
significantly
Spontaneous
standard oxygen therapy
Stata
status
stratified
stroke
study drug
Study protocol
subcutaneously
surgical
susceptible
symptomatic
syndrome
therapeutic dose
therapy
thrombocytopenia
time
transfusion
Treatment
unfractionated heparin
unit
Vascular
venipuncture
Venous Thromboembolism
web-based system
website
weight
Withdrawal
worsening
[DOI] 10.1186/s13063-020-04475-z PMC 바로가기 [Article Type] Letter
[DOI] 10.1186/s13063-020-04475-z PMC 바로가기 [Article Type] Letter
Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis
Zebrafish slc30a10 결핍은 망간 항상성을 유지하는 Atp2c1의 새로운 보상 메커니즘을 밝혀냈습니다
Research Article
[키워드] absence
accompanied
accumulated
activating
adulthood
approach
ATP2C1
ATPase
Author
Brain
can be used
characterized
cirrhosis
cirrhosis)
clinically
CRISPR
deficiency
degenerative
degenerative diseases
develop
disease
Disease model
disorder
dysregulation
dystonia
early-onset
EDTA
effective
Embryo
embryonic
ENCODE
expressing
expression
fibrosis
form
HeLa cells
hepatic injury
homeostasis
Impaired
impaired function
implicated
inhibit
iron
liver
Liver fibrosis
manganese
manganism
mechanism
metabolic disorder
metabolism
modulating
mutant
mutant embryo
mutant embryos
mutants
Mutation
neurological
Neurological deficit
neurological deficits
neurological impairment
pharmacological
phenotype
physiological
polycythemia
recent
reduce
rescued
secretory pathway
Signaling
significantly higher
SLC30A10
specific treatment
steatosis
therapy
underlie
wild-type
zebrafish
[DOI] 10.1371/journal.pgen.1006892 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1006892 PMC 바로가기 [Article Type] Research Article
Diminished COX-2/PGE 2 -Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells
Research Article
[키워드] A549 cell
A549 cells
addition
Affect
antiviral activity
antiviral response
Cell
cellular
chloride
coronavirus 229E
decrease
decreased expression
deficiency
diminished
downstream
DPI
dysregulated
expression
G6PD
glucose-6-phosphate dehydrogenase
homeostasis
Impaired
Infection
Inflammatory response
inhibitor
MAPK
NADPH
NADPH oxidase
NF-κB
occurred
oxidative stress
PGE
Phosphorylation
provide
reduced
reducing
Regulation
response
Signaling
subunit
susceptibility
These data
TNF-α
transcriptional level
Treatment
tumor necrosis factor-α
up-regulated
viral infections
viral replication
was determined
[DOI] 10.1371/journal.pone.0153462 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pone.0153462 PMC 바로가기 [Article Type] Research Article
Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response
대식세포에서 엔도글린이 결핍된 마우스는 손상된 면역 반응을 보여줍니다
Research Article
[키워드] absence
ACVRL1
analyzed
animals
Antigen
autosomal dominant
autosomal dominant disorder
auxiliary
Bacteria
balance
blood monocyte
blood monocytes
C57BL/6
cell line
characterized
conditions
contribute
deficiency
described
develop
differentiation
disorder
dominant
dysplasia
Endoglin
endotoxin
ENG
explain
expressed
expression
foci
function
help
hemorrhage
hemorrhages
Hereditary
Hereditary hemorrhagic telangiectasia
homeostasis
human cell
human macrophages
immune
immune response
Impaired
in vitro
in vivo
increased survival
Infection
infection rate
Infectious disease
Infectious diseases
Inflammation
internal organs
knock-out
Laboratory
leukemic
leukemic cell
Lineage
Macrophage
macrophages
malformation
mice
monocyte
monocyte-macrophage
Monocytes
Mortality
mouse macrophages
multisystemic
patients
Peripheral blood
peripheral blood monocytes
peritoneal macrophage
peritoneal macrophages
peritonitis
Phagocytic activity
predisposition
Prevalence
rare disease
receptor
recruited
Rendu-Osler-Weber syndrome
response
responsible
show
Signaling
surface antigen
syndrome
target gene
Target genes
TGF-β
TGF-β1
transmembrane protein
triggered
type I
up-regulation
Vascular
vessel wall
was reduced
Weber syndrome
wild-type
[DOI] 10.1371/journal.pgen.1005935 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1005935 PMC 바로가기 [Article Type] Research Article
CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with Hypomagnesemia
CNNM2 돌연변이는 저마그네슘혈증 환자의 뇌 발달 장애 및 발작을 유발합니다
Research Article
[키워드] accompanied
Affect
Brain
brain development
brain malformation
brain malformations
cation channel
cause
caused
Cell
cellular
clinical variability
CNNM2
Combination
cRNA
cyclin M2
de novo
de novo heterozygous missense mutations
demonstrated
development
Diagnosis
disease
Effect
embryonic
explain
expressing
FIVE
gene encoding
Genetic
genetic cause
genetic component
genetic disease
genetic etiology
genetic heterogeneity
handling
HEK293 cell
HEK293 cells
heterozygous
homeostasis
human disease
hypomagnesemia
identify
Impaired
IMPROVE
in vitro activity
increase
inheritance
injection
intellectual disability
isoform
kidney
knockdown
loss-of-function
Magnesium
mammalian
Mental
mental disability
mental retardation
Missense mutation
mutant
mutated
Mutation
neurodevelopmental impairment
neurodevelopmental impairments
neurological
Neurological diseases
occur
Pathomechanism
Pathomechanisms
Patient
patients with moderate
phenotype
Phenotypes
physiological
Physiology
Protein
reduced
Regulation
renal
rescued
Seizure
Seizures
shown
the disease
therapeutic drug
Treatment
TRPM7
unique
wild-type
zebrafish
[DOI] 10.1371/journal.pgen.1004267 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1004267 PMC 바로가기 [Article Type] Research Article
MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic Stress
MK2-의존성 p38b 신호는 만성 스트레스 하에서 JNK 유도 세포자멸사로부터 Drosophila Hindgut Enterocytes를 보호합니다
Research Article
[키워드] absence
addressed
affected
antimicrobial peptides
Apoptosis
atrophy
Author
branch
cascade
Cell
chronic
complex
component
contribute
damage
damaged
descendants
Deterioration
Diseases
Drosophila
Elimination
Enterocyte
enterocytes
epithelial
epithelium
event
form
genetic analysis
Gut
Hindgut
homeostasis
Impaired
induce
integrity
intestinal
Intestinal diseases
intestinal epithelium
intestinal stem cell
Intestinal stem cells
JNK
kinases
leads
less
manifested
pathogen
Pathogens
pathway
peptides
peptides)
Prevent
proliferation
PROTECT
Protective
Protein
protein kinase
replaced
REPLACED BY
Replenishment
required
salt
Signal transduction
stem cell
stem cells
Stress
Stressor
stressors
subsequent
suppresse
Trigger
triggers
upregulated
upstream
[DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article